The Effect of a Short Period of Supplementation with Glutamine Dipeptide on the Cognitive Responses after a Resistance Training Session of Women with HIV/AIDS: A Randomized Double-Blind Placebo-Controlled Crossover Study

Dayane Cristina de Souza, Junior Cesar da Silva, Felipe de Oliveira Matos, Alexandre Hideki Okano, Roberto Barbosa Bazotte, Ademar Avelar, Dayane Cristina de Souza, Junior Cesar da Silva, Felipe de Oliveira Matos, Alexandre Hideki Okano, Roberto Barbosa Bazotte, Ademar Avelar

Abstract

The aim of the present study was to investigate the effect of a short period of supplementation with glutamine dipeptide (GDP) on the acute responses to resistance training on the executive functions of people with HIV/AIDS. The sample consisted of 10 HIV+ women (45.00 ± 12.77 years old; 65.71 ± 12.04 kg; 1.54 ± 0.05 m) who were submitted to a randomized double-blind crossover procedure according to two experimental conditions: orally supplemented with 20 g/day of GDP or with maltodextrin for seven days. On the seventh day of supplementation all participants did cognitive function tests before and immediately after a resistance training session. Seven days of washout were adopted between conditions. Stroop and N-back tests were used to evaluate the executive functions. The training reduced the response time of each card in isolation and the latency time among them. GDP supplementation increased the magnitude of this effect, thus, reducing the latency time from the first to the last card in the Stroop test by almost 50% (P < 0.01). Considering the N-back test, there were no significant differences. It is suggested that GDP supplementation may increase the magnitude of the effect of an acute resistance training session in cognitive functions, particularly in the inhibitory control of people with HIV/AIDS. This trial is registered with NCT03236532.

Figures

Figure 1
Figure 1
Flow diagram.
Figure 2
Figure 2
Scheme of the experimental design.

References

    1. Tozzi V., Balestra P., Bellagamba R., et al. Persistence of neuropsychologic deficits despite long-term highly active antiretroviral therapy in patients with HIV-related neurocognitive impairment: prevalence and risk factors. Journal of Acquired Immune Deficiency Syndromes. 2007;45(2):174–182. doi: 10.1097/QAI.0b013e318042e1ee.
    1. Ghafouri M., Amini S., Khalili K., Sawaya B. E. HIV-1 associated dementia: symptoms and causes. Retrovirology. 2006;3(1, article 28) doi: 10.1186/1742-4690-3-28.
    1. Schouten J., Cinque P., Gisslen M., Reiss P., Portegies P. HIV-1 infection and cognitive impairment in the cART era: a review. AIDS. 2011;25(5):561–575. doi: 10.1097/QAD.0b013e3283437f9a.
    1. Valcour V. G. Evaluating cognitive impairment in the clinical setting: practical screening and Assessment tools. Topics in Antiviral Medicine. 2011;19(5):175–180.
    1. Tyor W. R., Wesselingh S. L., Griffin J. W., McArthur J. C., Griffin D. E. Unifying hypothesis for the pathogenesis of HIV-associated dementia complex, vacuolar myelopathy, and sensory neuropathy. Journal of Acquired Immune Deficiency Syndromes. 1995;9(4):379–388.
    1. Navia B. A., Jordan B. D., Price R. W. The AIDS dementia complex: I. Clinical features. Annals of Neurology. 1986;19(6):517–524. doi: 10.1002/ana.410190602.
    1. Diamond A. Executive functions. Annual Review of Psychology. 2013;64:135–168. doi: 10.1146/annurev-psych-113011-143750.
    1. Christo P. P. Cognitive alterations associated with HIV-1 infection and AIDS. Revista da Associação Médica Brasileira. 2010;56(2):242–247. doi: 10.1590/S0104-42302010000200027.
    1. Hestad K. A., Menon J. A., Hestad K. A., et al. Sex differences in neuropsychological performance as an effect of human immunodeficiency virus infection: a pilot study in Zambia, Africa. The Journal of Nervous and Mental Disease. 2012;200(4):336–342. doi: 10.1097/NMD.0b013e31824cc225.
    1. Vázquez-Justo E., Rodríguez-Álvarez M. Influence of factors not related with HIV infection on neuropsychological performance of HIV-seropositive patients. Revista de Neurologia. 2002;35(5):474–480.
    1. Busse A. L., Filho W. J., Magaldi R. M., Coelho V., Melo A. C., Betoni R. A. Effects of resistance training exercise on cognitive performance in elderly individuals with memory impairment: results of a controlled trial. Einstein Journal. 2008;6(4):402–407.
    1. Cassilhas R. C., Viana V. A., Grassmann V., et al. The impact of resistance exercise on the cognitive function of the elderly. Medicine and Science in Sports and Exercise. 2007;39(8):1401–1407. doi: 10.1249/mss.0b013e318060111f.
    1. Lima A. A. M., Kvalsund M. P., de Souza P. P. E., et al. Zinc, vitamin A, and glutamine supplementation in Brazilian shantytown children at risk for diarrhea results in sex-specific improvements in verbal learning. Clinics. 2013;68(3):351–358. doi: 10.6061/clinics/2013(03)OA11.
    1. Rest O., van der Zwaluw N. L., Tieland M., et al. Effect of resistance-type exercise training with or without protein supplementation on cognitive functioning in frail and pre-frail elderly: secondary analysis of a randomized, double-blind, placebo-controlled trial. Mechanisms of Ageing and Development. 2014;136:85–93. doi: 10.1016/j.mad.2013.12.005.
    1. Antunes H. K., Santos R. F., Cassilhas R., Santos R. V., Bueno O. F., Mello M. T. Exercício físico e função cognitiva: uma revisão. Revista Brasileira de Medicina do Esporte. 2006;12(2):108–114. doi: 10.1590/S1517-86922006000200011.
    1. Bossers W. J. R., Van Der Woude L. H. V., Boersma F., Hortobágyi T., Scherder E. J. A., Van Heuvelen M. J. G. A 9-week aerobic and strength training program improves cognitive and motor function in patients with dementia: a randomized, controlled trial. The American Journal of Geriatric Psychiatry. 2015;23(11):1106–1116. doi: 10.1016/j.jagp.2014.12.191.
    1. Davis J. C., Bryan S., Marra C. A., Hsiung G.-Y. R., Liu-Ambrose T. Challenges with cost-utility analyses of behavioural interventions among older adults at risk for dementia. British Journal of Sports Medicine. 2015;49(20):1343–1347. doi: 10.1136/bjsports-2013-092743.
    1. Graff-Radford N. R. Can aerobic exercise protect against dementia? Alzheimer's Research and Therapy. 2011;3(1, article 6) doi: 10.1186/alzrt65.
    1. Liu-Ambrose T., Nagamatsu L. S., Graf P., Beattie B. L., Ashe M. C., Handy T. C. Resistance training and executive functions: a 12-month randomized controlled trial. JAMA Internal Medicine. 2010;170(2):170–178. doi: 10.1001/archinternmed.2009.494.
    1. Chang Y.-K., Etnier J. L. Effects of an acute bout of localized resistance exercise on cognitive performance in middle-aged adults: a randomized controlled trial study. Psychology of Sport and Exercise. 2009;10(1):19–24. doi: 10.1016/j.psychsport.2008.05.004.
    1. Chang Y.-K., Ku P.-W., Tomporowski P. D., Chen F.-T., Huang C.-C. Effects of acute resistance exercise on late-middle-age adults' goal planning. Medicine & Science in Sports & Exercise. 2012;44(9):1773–1779. doi: 10.1249/MSS.0b013e3182574e0b.
    1. Chang Y.-K., Tsai C.-L., Huang C.-C., Wang C.-C., Chu I.-H. Effects of acute resistance exercise on cognition in late middle-aged adults: general or specific cognitive improvement? Journal of Science and Medicine in Sport. 2014;17(1):51–55. doi: 10.1016/j.jsams.2013.02.007.
    1. Fazeli P. L., Woods S. P., Heaton R. K., et al. An active lifestyle is associated with better neurocognitive functioning in adults living with HIV infection. Journal of NeuroVirology. 2014;20(3):233–242. doi: 10.1007/s13365-014-0240-z.
    1. Ortega M., Baker L. M., Vaida F., Paul R., Basco B., Ances B. M. Physical activity affects brain integrity in HIV+ individuals. Neuropsychological Society. 2015;21(10):880–889. doi: 10.1017/S1355617715000879.
    1. Dufour C. A., Marquine M. J., Fazeli P. L., et al. Physical exercise is associated with less neurocognitive impairment among HIV-infected adults. Journal of NeuroVirology. 2013;19(5):410–417. doi: 10.1007/s13365-013-0184-8.
    1. McDermott A., Zaporojan L., McNamara P., et al. The effects of a 16-week aerobic exercise programme on cognitive function in people living with HIV. AIDS care. 2017;29(6):667–674. doi: 10.1080/09540121.2016.1263723.
    1. Newsholme P., Lima M. M. R., Procopio J., et al. Glutamine and glutamate as vital metabolites. Brazilian Journal of Medical and Biological Research. 2003;36(2):153–163. doi: 10.1590/s0100-879x2003000200002.
    1. Deitmer J. W., Bröer A., Bröer S. Glutamine efflux from astrocytes is mediated by multiple pathways. Journal of Neurochemistry. 2003;87(1):127–135. doi: 10.1046/j.1471-4159.2003.01981.x.
    1. Borges-Santos M. D., Moreto F., Pereira P. C. M., Ming-Yu Y., Burini R. C. Plasma glutathione of HIV+ patients responded positively and differently to dietary supplementation with cysteine or glutamine. Nutrition Journal . 2012;28(7-8):753–756. doi: 10.1016/j.nut.2011.10.014.
    1. Leones J. R., Brito M. D., Caporossi C. A Influencia da Glutamina como Imunofarmaconutriente para Controle de Alteracoes Metabolicas em Pacientes com HIV/AIDS. COORTE-Revista Científica do Hospital Santa Rosa. 2016;(3):37–44.
    1. Murden R. A., McRae T. D., Kaner S., Bucknam M. E. Mini-mental state exam scores vary with education in black and whites. Journal of the American Geriatrics Society. 1991;39(2):149–155. doi: 10.1111/j.1532-5415.1991.tb01617.x.
    1. Rodrigues R. A., Oliveira R. L., Grinsztejn B., Silva M. T. T. Validity of the International HIV Dementia Scale in Brazil. Arquivos de Neuro-Psiquiatria. 2013;71(6):376–379. doi: 10.1590/0004-282X20130042.
    1. Spreen O., Strauss E. Administration, Norms, and Commentary. New York, NY, USA: Oxford University Press; 1998. A compendium of neuropsychological tests.
    1. De Nardi T., Sanvicente-Vieira B., Prando M., Stein L. M., Fonseca R. P., Grassi-Oliveira R. Auditory N-back task: different age groups performance. Psicologia: Reflexao e Critica. 2013;26(1):151–159. doi: 10.1590/S0102-79722013000100016.
    1. Grace J. M., Semple S. J., Combrink S. “Exercise therapy for human immunodeficiency virus/AIDS patients: guidelines for clinical exercise therapists. Journal of Exercise Science and Fitness. 2015;13(1):49–56. doi: 10.1016/j.jesf.2014.10.003.
    1. Dillon D. G., Pizzagalli D. A. Inhibition of action, thought, and emotion: a selective neurobiological review. Applied and Preventive Psychology. 2007;12(3):99–114. doi: 10.1016/j.appsy.2007.09.004.
    1. Browne R. A. V., Costa E. C., Sales M. M., Fonteles A. I., Moraes J. F. V. N. D., Barros J. D. F. Acute effect of vigorous aerobic exercise on the inhibitory control in adolescents. Revista Paulista de Pediatria. 2016;34(2):154–161. doi: 10.1016/j.rppede.2016.01.005.
    1. Calomeni M. R., Silva V. F., Ribeiro L. H. B., Cavalcante J., Siza M. A. F. Exercicio fisico e plasticidade neurogenica: benefícios relacionados as funcoes mentais do idoso. Biologicas and Saude. 2012;2(6)
    1. Chen A.-G., Yan J., Yin H.-C., Pan C.-Y., Chang Y.-K. Effects of acute aerobic exercise on multiple aspects of executive function in preadolescent children. Psychology of Sport and Exercise. 2014;15(6):627–636. doi: 10.1016/j.psychsport.2014.06.004.
    1. Nanda B., Balde J., Manjunatha S. The acute effects of a single bout of moderate-intensity aerobic exercise on cognitive functions in healthy adult males. Journal of Clinical and Diagnostic Research. 2013;7(9):1883–1885. doi: 10.7860/JCDR/2013/5855.3341.
    1. Xu X., Jerskey B. A., Cote D. M., et al. Cerebrovascular perfusion among older adults is moderated by strength training and gender. Neuroscience Letters. 2014;560:26–30. doi: 10.1016/j.neulet.2013.12.011.
    1. Kramer A. F., Colcombe S. J., McAuley E., Scalf P. E., Erickson K. I. Fitness, aging and neurocognitive function. Neurobiology of Aging. 2005;26(1):124–127. doi: 10.1016/j.neurobiolaging.2005.09.009.
    1. Paillard T. Preventive effects of regular physical exercise against cognitive decline and the risk of dementia with age advancement. Sports Medicine. 2015;1(1, article 20) doi: 10.1186/s40798-015-0016-x.
    1. Albrecht J., Sidoryk-Wȩgrzynowicz M., Zielińska M., Aschner M. Roles of glutamine in neurotransmission. Neuron Glia Biology. 2010;6(4):263–276. doi: 10.1017/S1740925X11000093.
    1. Strüder H. K., Weicker H. Physiology and pathophysiology of the serotonergic system and its implications on mental and physical performance. Part II. International Journal of Sports Medicine. 2001;22(7):482–497. doi: 10.1055/s-2001-17606.
    1. Ando S., Kokubu M., Yamada Y., Kimura M. Does cerebral oxygenation affect cognitive function during exercise? European Journal of Applied Physiology. 2011;111(9):1973–1982. doi: 10.1007/s00421-011-1827-1.
    1. Berk M., Ng F., Dean O., Dodd S., Bush A. I. Glutathione: a novel treatment target in psychiatry. Trends in Pharmacological Sciences. 2008;29(7):346–351. doi: 10.1016/j.tips.2008.05.001.
    1. Ellis R. J., Joseph J., de Almeida S. M. NeuroAIDS in Brazil. Journal of NeuroVirology. 2007;13(2):89–96. doi: 10.1080/13550280601132074.
    1. Mormont E., Laloux P. Strategie therapeutique dans le traitement initial de la maladie de Parkinson. Louvion Medical. 2002;121(4):93–99. doi: 10.1016/j.lpm.2006.09.011.
    1. Ballatori N., Krance S. M., Notenboom S., Shi S., Tieu K., Hammond C. L. Glutathione dysregulation and the etiology and progression of human diseases. Biological Chemistry. 2009;390(3):191–214. doi: 10.1515/BC.2009.033.
    1. Suarez I., Bodega G., Fernandez B. Glutamine synthetase in brain: effect of ammonia. Neurochemistry International. 2002;41(2-3):123–142. doi: 10.1016/S0197-0186(02)00033-5.
    1. Pruna G. J., Hoffman J. R., McCormack W. P., et al. Effect of acute L-Alanyl-L-Glutamine and electrolyte ingestion on cognitive function and reaction time following endurance exercise. European Journal of Sport Science. 2016;16(1):72–79. doi: 10.1080/17461391.2014.969325.
    1. McAllister T. W., Sparling M. B., Flashman L. A., Saykin A. J. Neuroimaging findings in mild traumatic brain injury. Journal of Clinical and Experimental Neuropsychology. 2001;23(6):775–791. doi: 10.1076/jcen.23.6.775.1026.
    1. Baddeley A. D. Working memory: looking back and looking forward. Nature Reviews Neuroscience. 2003;4(10):829–839. doi: 10.1038/nrn1201.

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