Incidence and risk factors of early delirium after cardiac surgery

Ieva Norkienė, Donata Ringaitienė, Vilma Kuzminskaitė, Jūratė Šipylaitė, Ieva Norkienė, Donata Ringaitienė, Vilma Kuzminskaitė, Jūratė Šipylaitė

Abstract

Introduction: The aim of our study was to identify the incidence and risk factors of delirium after cardiac surgery implementing Intensive Care Delirium Screening Checklist (ICDSC).

Material and methods: 87 patients, undergoing cardiac surgery at Vilnius University hospital, were prospectively monitored for postoperative delirium development, during intensive care unit stay.

Results: The incidence of postoperative delirium was 13.30%. No statistically relevant preoperative predictors of delirium were found. The duration of surgery was significantly longer in delirium group (4.51 ± 1.15 versus 3.76 ± 0.97 hours, P = 0.017). Patients in delirium group more often had blood product transfusions (1.50 (± 1.57) versus 0.49 (± 0.91) P = 0.003) and had a higher incidence of low cardiac output syndrome (33.30% versus 3.00%, P = 0.004); they were significantly longer mechanically ventilated (24.31 ± 28.35 versus 8.78 ± 4.77 (P < 0.001)) hours (OR = 1.15 (1.02-1.28)) and had twice longer ICU stay (5.00 ± 2.22 versus 2.60 ± 1.10 (P < 0.001)) days (OR = 1.91 (1.22-3.00)).

Conclusions: The incidence of delirium after cardiac surgery was 13.3%. Independent predictors of delirium were duration of postoperative mechanical ventilation and intensive care unit stay.

References

    1. American Psychiatric Association. Diagnostic and Statistical Manual. 4th edition. Washington, DC, USA: APA Press; 1994.
    1. Deiner S, Silverstein JH. Postoperative delirium and cognitive dysfunction. British Journal of Anaesthesia. 2009;103:i41–i46.
    1. Mittal V, Muralee S, Williamson D, et al. Delirium in the elderly: a comprehensive review. American Journal of Alzheimer’s Disease and other Dementias. 2011;26(2):97–109.
    1. Miller RR, III, Ely EW. Delirium and cognitive dysfunction in the intensive care unit. Seminars in Respiratory and Critical Care Medicine. 2006;27(3):210–220.
    1. Neto AS, Nassar AP, Cardoso SO, et al. Delirium screening in critically ill patients: a systematic review and meta-analysis. Critical Care Medicine. 2012;40:1946–1951.
    1. Devlin JW, Fong JJ, Fraser GL, Riker RR. Delirium assessment in the critically ill. Intensive Care Medicine. 2007;33(6):929–940.
    1. Zhang Z, Pan L, Ni H. Impact of delirium on clinical outcome in critically ill patients: a meta analysis. General Hospital Psychiatry . 2013;35:105–111.
    1. Banerjee A, Girard TD, Pandharipande P. The complex interplay between delirium, sedation, and early mobility during critical illness: applications in the trauma unit. Current Opinion in Anaesthesiology. 2011;24(2):195–201.
    1. Zimpfer D, Czerny M, Kilo J, et al. Cognitive deficit after aortic valve replacement. Annals of Thoracic Surgery. 2002;74(2):407–412.
    1. Brækken SK, Reinvang I, Russell D, Brucher R, Svennevig JL. Association between intraoperative cerebral microembolic signals and postoperative neuropsychological deficit: comparison between patients with cardiac valve replacement and patients with coronary artery bypass grafting. Journal of Neurology Neurosurgery and Psychiatry. 1998;65(4):573–576.
    1. Hudetz JA, Iqbal Z, Gandhi SD, Patterson KM, Byrne AJ, Pagel PS. Postoperative delirium and short-term cognitive dysfunction occur more frequently in patients undergoing valve surgery with or without coronary artery bypass graft surgery compared with coronary artery bypass graft surgery alone: results of a pilot study. Journal of Cardiothoracic and Vascular Anesthesia. 2011;25(5):811–816.
    1. Bergeron N, Dubois M-J, Dumont M, Dial S, Skrobik Y. Intensive care delirium screening checklist: evaluation of a new screening tool. Intensive Care Medicine. 2001;27(5):859–864.
    1. Steiner LA. Postoperative delirium. Part 1: pathophysiology and risk factors. European Journal of Anaesthesiology. 2011;28(9):628–636.
    1. van den Boogaard M, Pickkers P, Slooter AJ, et al. Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study. British Medical Journal. 2012;344, article e420
    1. Lin J Chen Z Wang Y. Meta-analysis of factors which influence delirium following cardiac surgery. Journal of Cardiac Surgery. 2012;27:481–492.
    1. Atti AR, Palmer K, Volpato S, Zuliani G, Winblad B, Fratiglioni L. Anaemia increases the risk of dementia in cognitively intact elderly. Neurobiology of Aging. 2006;27(2):278–284.
    1. Barr J, Fraser GL, Puntillo K, et al. Clinical practice guidelines for management of pain agitation and delirium in adult patients in intensive care unit. Critical Care Medicine. 2013;41:278–280.
    1. Neziraj M, Sarac Kart N, Samuelson K. The intensive care delirium screening checklist: translation and reliability testing in a Swedish ICU. Acta Anaesthesiologica Scandinavica. 2011;55(7):819–826.

Source: PubMed

3
Předplatit