Cetirizine modifies quality of life and symptoms in children with seasonal allergic rhinitis: a pilot study

Marco Benazzo, Salvatore Leonardi, Angelo Corsico, Amelia Licari, Michele Miraglia Del Giudice, Diego Peroni, Carmelo Salpietro, Gian Luigi Marseglia, Giorgio Ciprandi, Marco Benazzo, Salvatore Leonardi, Angelo Corsico, Amelia Licari, Michele Miraglia Del Giudice, Diego Peroni, Carmelo Salpietro, Gian Luigi Marseglia, Giorgio Ciprandi

Abstract

Background and aim Seasonal allergic rhinitis (SAR) is a common disease in childhood that is characterized by bothersome symptoms and impaired quality of life (QoL). As histamine is the pivotal pathogenic mediator in SAR, antihistamines are the first-line option in the treatment. Cetirizine is a well-known effective antihistamine. This real-life pilot study aimed to investigate the effectiveness of a 4-week continuous cetirizine treatment in a group of Italian children with SAR. Methods Total symptom score (TSS) and the Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ) were assessed at baseline and the end of the treatment. Results Cetirizine significantly improved QoL (in all domains) and symptom severity (p<0.001 for both). Conclusions The present preliminary study showed that a 4-week cetirizine treatment was able to improve QoL significantly. Cetirizine treatment also significantly reduced symptom severity in Italian children with SAR and was safe.

Conflict of interest statement

all authors declare that have no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article.

Figures

Figure 1.
Figure 1.
Total Score of QoL at baseline and after the treatment.
Figure 2.
Figure 2.
Total Symptom Score at baseline and after the treatment.

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Source: PubMed

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