Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals

Ivan Seah, Rupesh Agrawal, Ivan Seah, Rupesh Agrawal

Abstract

In December 2019, a novel coronavirus (CoV) epidemic, caused by the severe acute respiratory syndrome coronavirus - 2 (SARS-CoV-2) emerged from China. This virus causes the coronavirus disease 2019 (COVID-19). Since then, there have been anecdotal reports of ocular infection. The ocular implications of human CoV infections have not been widely studied. However, CoVs have been known to cause various ocular infections in animals. Clinical entities such as conjunctivitis, anterior uveitis, retinitis, and optic neuritis have been documented in feline and murine models. In this article, the current evidence suggesting possible human CoV infection of ocular tissue is reviewed. The review article will also highlight animal CoVs and their associated ocular infections. We hope that this article will serve as a start for further research into the ocular implications of human CoV infections.

Keywords: COVID-19; Coronavirus; coronavirus disease 2019; novel coronavirus; severe acute respiratory syndrome coronavirus-2.

References

    1. Salata C, Calistri A, Parolin C, Palu G.. Coronaviruses: a paradigm of new emerging zoonotic diseases. Pathog Dis. 2020;77(9).
    1. Loon SC, Lun K. SARS: a timely reminder. Br J Ophthalmol. 2013;97(9):1217–1218. doi:10.1136/bjophthalmol-2013-303596.
    1. (WHO) WHO Summary table of SARS cases by country, 1 November 2002-7 August 2003. Summary Table of SARS Cases by Country N-A. Geneva (Switzerland): World Health Organisation (WHO); 2003
    1. Chafekar A, Fielding BC. MERS-CoV: understanding the latest human coronavirus threat. Viruses. 2018;10(2):93.
    1. Organisation WH Coronavirus disease 2019 (COVID-19) situation report 32. . 2020.
    1. Organisation WH Statement on the second meeting of the international health regulations (2005) emergency committee regarding the outbreak of novel coronavirus (2019-nCoV). ). 2020.
    1. Organisation WH Infection prevention and control during health care when novel coronavirus (nCoV) infection is suspected. . 2020.
    1. Madhugiri R, Fricke M, Marz M, Ziebuhr J. Coronavirus cis-acting RNA elements. Adv Virus Res. 2016;96:127–163.
    1. Chen Y, Liu Q, Guo D. Coronaviruses: genome structure, replication, and pathogenesis. J Med Virol. 2020;92:418–423.
    1. Tekes G, Thiel HJ. Feline coronaviruses: pathogenesis of feline infectious peritonitis. Adv Virus Res. 2016;96:193–218.
    1. van Nguyen D, Terada Y, Minami S, et al. Characterization of canine coronavirus spread among domestic dogs in Vietnam. J Vet Med Sci. 2017;79(2):343–349. doi:10.1292/jvms.16-0538.
    1. Mihindukulasuriya KA, Wu G, St Leger J, Nordhausen RW, Wang D. Identification of a novel coronavirus from a beluga whale by using a panviral microarray. J Virol. 2008;82(10):5084–5088. doi:10.1128/JVI.02722-07.
    1. Woo PC, Lau SK, Huang Y, Yuen KY. Coronavirus diversity, phylogeny and interspecies jumping. Exp Biol Med (Maywood). 2009;234(10):1117–1127. doi:10.3181/0903-MR-94.
    1. Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol. 2019;17(3):181–192. doi:10.1038/s41579-018-0118-9.
    1. Corman VM, Muth D, Niemeyer D, Drosten C. Hosts and sources of endemic human coronaviruses. Adv Virus Res. 2018;100:163–188.
    1. Vassilara F, Spyridaki A, Pothitos G, Deliveliotou A, Papadopoulos A. A rare case of human coronavirus 229E associated with acute respiratory distress syndrome in a healthy adult. Case Rep Infect Dis. 2018;2018:6796839.
    1. Gralinski LE, Baric RS. Molecular pathology of emerging coronavirus infections. J Pathol. 2015;235(2):185–195. doi:10.1002/path.4454.
    1. Loon S-C, Teoh SCB, Oon LLE, et al. The severe acute respiratory syndrome coronavirus in tears. British J Ophthalmol. 2004;88(7):861–863. doi:10.1136/bjo.2003.035931.
    1. Yeo C, Kaushal S, Yeo D. Enteric involvement of coronaviruses: is faecal & oral transmission of SARS-CoV-2 possible? Lancet Gastroenterol Hepatol. 2020. epub ahead of print. doi:10.1016/S2468-1253(20)30048-0.
    1. Hung LS. The SARS epidemic in Hong Kong: what lessons have we learned? J R Soc Med. 2003;96(8):374–378. doi:10.1177/014107680309600803.
    1. Wang XW, Li J, Guo T, et al. Concentration and detection of SARS coronavirus in sewage from Xiao Tang Shan hospital and the 309th hospital of the Chinese people’s liberation army. Water Sci Technol. 2005;52(8):213–221. doi:10.2166/wst.2005.0266.
    1. Zhang W, Du RH, Li B, et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect. 2020;9(1):386–389. doi:10.1080/22221751.2020.1729071.
    1. van der Hoek L, Pyrc K, Jebbink MF, et al. Identification of a new human coronavirus. Nat Med. 2004;10(4):368–373. doi:10.1038/nm1024.
    1. Vabret A, Mourez T, Dina J, et al. Human coronavirus NL63, France. Emerg Infect Dis. 2005;11(8):1225–1229. doi:10.3201/eid1108.050110.
    1. Tong T, Lai TS. The severe acute respiratory syndrome coronavirus in tears. Br J Ophthalmol. 2005;89(3):392. doi:10.1136/bjo.2004.054130.
    1. Chan WM, Yuen KS, Fan DS, Lam DS, Chan PK, Sung JJ. Tears and conjunctival scrapings for coronavirus in patients with SARS. Br J Ophthalmol. 2004;88(7):968–969. doi:10.1136/bjo.2003.039461.
    1. Yan A. Chinese expert who came down with Wuhan coronavirus after saying it was controllable thinks he was infected through his eyes China: South China morning post. . 2020.
    1. Lu CW, Liu XF, Jia ZF. 2019-nCoV transmission through the ocular surface must not be ignored. Lancet. 2020;395(10224):e39. doi:10.1016/S0140-6736(20)30313-5.
    1. Seah I, Su X, Lingam G. Revisiting the dangers of the coronavirus in the ophthalmology practice. Eye (Lond). 2020. doi:10.1038/s41433-020-0790-7.
    1. Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS. J Virol. 2020. epub ahead of print. doi:10.1128/JVI.00127-20.
    1. Holappa M, Vapaatalo H, Vaajanen A. Many faces of renin-angiotensin system - focus on eye. Open Ophthalmol J. 2017;11(1):122–142. doi:10.2174/1874364101711010122.
    1. Hohdatsu T, Okada S, Ishizuka Y, Yamada H, Koyama H. The prevalence of types I and II feline coronavirus infections in cats. J Vet Med Sci. 1992;54(3):557–562. doi:10.1292/jvms.54.557.
    1. Pedersen NC, Boyle JF, Floyd K, Fudge A, Barker J. An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis. Am J Vet Res. 1981;42:368–377.
    1. Jaimes JA, Whittaker GR. Feline coronavirus: insights into viral pathogenesis based on the spike protein structure and function. Virology. 2018;517:108–121. doi:10.1016/j.virol.2017.12.027.
    1. Chang HW, Egberink HF, Rottier PJ. Sequence analysis of feline coronaviruses and the circulating virulent/avirulent theory. Emerg Infect Dis. 2011;17(4):744–746. doi:10.3201/eid1704.102027.
    1. Pedersen NC, Liu H, Scarlett J, et al. Feline infectious peritonitis: role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats. Virus Res. 2012;165(1):17–28. doi:10.1016/j.virusres.2011.12.020.
    1. Kipar A, May H, Menger S, Weber M, Leukert W, Reinacher M. Morphologic features and development of granulomatous vasculitis in feline infectious peritonitis. Vet Pathol. 2005;42(3):321–330. doi:10.1354/vp.42-3-321.
    1. de Groot-mijnes JD, van Dun JM, van der Most RG, de Groot RJ. Natural history of a recurrent feline coronavirus infection and the role of cellular immunity in survival and disease. J Virol. 2005;79(2):1036–1044. doi:10.1128/JVI.79.2.1036-1044.2005.
    1. Hok K. Morbidity, mortality and coronavirus antigen in previously coronavirus free kittens placed in two catteries with feline infectious peritonitis. Acta Vet Scand. 1993;34:203–210.
    1. Doherty MJ. Ocular manifestations of feline infectious peritonitis. J Am Vet Med Assoc. 1971;159:417–424.
    1. Homberger FR, Zhang L, Barthold SW. Prevalence of enterotropic and polytropic mouse hepatitis virus in enzootically infected mouse colonies. Lab Anim Sci. 1998;48:50–54.
    1. Bailey OT, Pappenheimer AM, Cheever FS, Daniels JB. A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin: II. Pathology. J Exp Med. 1949;90(3):195–212. doi:10.1084/jem.90.3.195.
    1. Dick GW, Niven JS, Gledhill AW. A virus related to that causing hepatitis in mice (MHV). Br J Exp Pathol. 1956;37:90–98.
    1. De Albuquerque N, Baig E, Ma X, et al. Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. J Virol. 2006;80(21):10382–10394. doi:10.1128/JVI.00747-06.
    1. Williams RK, Jiang GS, Holmes KV. Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins. Proc Natl Acad Sci USA. 1991;88(13):5533–5536. doi:10.1073/pnas.88.13.5533.
    1. Nakagaki K, Nakagaki K, Taguchi F. Receptor-independent spread of a highly neurotropic murine coronavirus JHMV strain from initially infected microglial cells in mixed neural cultures. J Virol. 2005;79(10):6102–6110. doi:10.1128/JVI.79.10.6102-6110.2005.
    1. Manaker RA, Piczak CV, Miller AA, Stanton MF. A hepatitis virus complicating studies with mouse leukemia. J Natl Cancer Inst. 1961;27:29–51.
    1. Robbins SG, Detrick B, Hooks JJ. Retinopathy following intravitreal injection of mice with MHV strain JHM. Adv Exp Med Biol. 1990;276:519–524.
    1. Hooks JJ, Percopo C, Wang Y, Detrick B. Retina and retinal pigment epithelial cell autoantibodies are produced during murine coronavirus retinopathy. J Immunol. 1993;151:3381–3389.
    1. Shindler KS, Kenyon LC, Dutt M, Hingley ST, Das Sarma J. Experimental optic neuritis induced by a demyelinating strain of mouse hepatitis virus. J Virol. 2008;82(17):8882–8886. doi:10.1128/JVI.00920-08.

Source: PubMed

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