Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases
U Pastorino, M Buyse, G Friedel, R J Ginsberg, P Girard, P Goldstraw, M Johnston, P McCormack, H Pass, J B Putnam Jr, International Registry of Lung Metastases, P Goldstraw, U Pastorino, J Cerrina, A Chapelier, P Dartevelle, P Baldeyrou, P Girard, D Grunenwald, H Bulzebruck, J Schirren, I Vogt-Moykopf, G Friedel, H Toomes, A N van Geel, M Capello, P Rocmans, A Pietraszek, M Sklodwska, S Andreani, M Incarbone, G Ravasi, L Tavecchio, V Ambrogi, C Ricci, T Mineo, G Maggi, A Briccoli, R Gelmini, A Heidari, N Guernelli, V Beltrami, M S Bains, M E Burt, R J Ginsberg, N Martini, P M McCormack, V W Rusch, J B Putnam Jr, J Roth, C Holmes, H Pass, B Temeck, M Johnston, M Buyse, P Marchand, S Nazari, U Pastorino, M Buyse, G Friedel, R J Ginsberg, P Girard, P Goldstraw, M Johnston, P McCormack, H Pass, J B Putnam Jr, International Registry of Lung Metastases, P Goldstraw, U Pastorino, J Cerrina, A Chapelier, P Dartevelle, P Baldeyrou, P Girard, D Grunenwald, H Bulzebruck, J Schirren, I Vogt-Moykopf, G Friedel, H Toomes, A N van Geel, M Capello, P Rocmans, A Pietraszek, M Sklodwska, S Andreani, M Incarbone, G Ravasi, L Tavecchio, V Ambrogi, C Ricci, T Mineo, G Maggi, A Briccoli, R Gelmini, A Heidari, N Guernelli, V Beltrami, M S Bains, M E Burt, R J Ginsberg, N Martini, P M McCormack, V W Rusch, J B Putnam Jr, J Roth, C Holmes, H Pass, B Temeck, M Johnston, M Buyse, P Marchand, S Nazari
Abstract
Objectives: The International Registry of Lung Metastases was established in 1991 to assess the long-term results of pulmonary metastasectomy.
Methods: The Registry has accrued 5206 cases of lung metastasectomy, from 18 departments of thoracic surgery in Europe (n = 13), the United States (n = 4) and Canada (n = 1). Of these patients, 4572 (88%) underwent complete surgical resection. The primary tumor was epithelial in 2260 cases, sarcoma in 2173, germ cell in 363, and melanoma in 328. The disease-free interval was 0 to 11 months in 2199 cases, 12 to 35 months in 1857, and more than 36 months in 1620. Single metastases accounted for 2383 cases and multiple lesions for 2726. Mean follow-up was 46 months. Analysis was performed by Kaplan-Meier estimates of survival, relative risks of death, and multivariate Cox model.
Results: The actuarial survival after complete metastasectomy was 36% at 5 years, 26% at 10 years, and 22% at 15 years (median 35 months); the corresponding values for incomplete resection were 13% at 5 years and 7% at 10 years (median 15 months). Among complete resections, the 5-year survival was 33% for patients with a disease-free interval of 0 to 11 months and 45% for those with a disease-free interval of more than 36 months; 43% for single lesions and 27% for four or more lesions. Multivariate analysis showed a better prognosis for patients with germ cell tumors, disease-free intervals of 36 months or more, and single metastases.
Conclusions: These results confirm that lung metastasectomy is a safe and potentially curative procedure. Resectability, disease-free interval, and number of metastases enabled us to design a simple system of classification valid for different tumor types.
Source: PubMed