Pharmacokinetics of 38% topical silver diamine fluoride in healthy adult volunteers
Yvonne S Lin, Marilynn L Rothen, Peter Milgrom, Yvonne S Lin, Marilynn L Rothen, Peter Milgrom
Abstract
Background: Silver diamine fluoride (SDF) is used topically to prevent or arrest caries. The authors' aim was to characterize the kinetics of silver and fluoride after topical application of SDF.
Methods: Sixteen adults participated in a pharmacokinetics study after the application of 38% SDF to 5 teeth (approximately 50 microliters, estimated 4-11 milligrams per participant). Serum and urine samples were collected over 24 hours after application and were analyzed for silver and fluoride.
Results: Silver serum peak was 0.67 (standard deviation [SD], 0.49) nanograms per milliliter; median time to peak was 3 hours. The estimated elimination half-life of silver was 46 (SD, 26) hours. No silver was recovered in urine. Baseline fluoride serum levels ranged from less than 10 through 50 ng/mL (< 0.01-0.05 parts per million) and fluctuated around baseline after SDF. The 24-hour urinary fluoride was 1.29 (SD, 0.81) mg.
Conclusions: SDF was well tolerated in this study, and no adverse events related to SDF were reported.
Practical implications: This clinical study confirmed that topical application of 38% SDF, in growing use in the United States, is safe and well tolerated in healthy adults.
Keywords: Silver diamine fluoride; clinical study; dental; healthy volunteers.
Conflict of interest statement
Declaration of Conflicting Interests:
PM is a director of Advantage Silver Dental Arrest, LLC. The other authors declare no conflict of interest.
Copyright © 2019 American Dental Association. Published by Elsevier Inc. All rights reserved.
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Source: PubMed