Loss of household protection from use of insecticide-treated nets against pyrethroid-resistant mosquitoes, benin

Alex Asidi, Raphael N'Guessan, Martin Akogbeto, Chris Curtis, Mark Rowland, Alex Asidi, Raphael N'Guessan, Martin Akogbeto, Chris Curtis, Mark Rowland

Abstract

Pyrethroid resistance is becoming widespread in Anopheles gambiae mosquitoes, coinciding with expanded use of insecticide-treated nets (ITNs) throughout Africa. To investigate whether nets in use are still protective, we conducted household trials in northern and southern Benin, where An. gambiae mosquitoes are susceptible and resistant, respectively, to pyrethroids. Rooms were fitted with window traps and monitored for mosquito biting and survival rates before and after the nets were treated with pyrethroid. Sleeping under an ITN in the location with resistant mosquitoes was no more protective than sleeping under an untreated net, regardless of its physical condition. By contrast, sleeping under an ITN in the location with susceptible mosquitoes decreased the odds of biting by 66%. ITNs provide little or no protection once the mosquitoes become resistant and the netting acquires holes. Resistance seriously threatens malaria control strategies based on ITN.

Figures

Figure
Figure
Death rates of Anopheles gambiae s.l. mosquitoes collected in exit traps at Mallanville (where mosquitoes are pyrethroid susceptible) in northern Benin and Fifadji (where mosquitoes are pyrethroid resistant) in southern Benin, 2008. Error bars indicate 95% CIs.

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