Irreversible Electroporation in Hepatopancreaticobiliary Tumours
A H Ruarus, L G P H Vroomen, R S Puijk, H J Scheffer, B M Zonderhuis, G Kazemier, M P van den Tol, F H Berger, M R Meijerink, A H Ruarus, L G P H Vroomen, R S Puijk, H J Scheffer, B M Zonderhuis, G Kazemier, M P van den Tol, F H Berger, M R Meijerink
Abstract
Hepatopancreaticobiliary tumours are often diagnosed at an advanced disease stage, in which encasement or invasion of local biliary or vascular structures has already occurred. Irreversible electroporation (IRE) is an image-guided tumour ablation technique that induces cell death by exposing the tumour to high-voltage electrical pulses. The cellular membrane is disrupted, while sparing the extracellular matrix of critical tubular structures. The preservation of tissue integrity makes IRE an attractive treatment option for tumours in the vicinity of vital structures such as splanchnic blood vessels and major bile ducts. This article reviews current data and discusses future trends of IRE for hepatopancreaticobiliary tumours.
Keywords: IRE; Irreversible electroporation; Liver neoplasms; Pancreatic neoplasms; Perihilar cholangiocarcinoma.
Copyright © 2017 Canadian Association of Radiologists. Published by Elsevier Inc. All rights reserved.
Source: PubMed