Relationship of exercise volume to improvements of quality of life with supervised exercise training in patients with type 2 diabetes in a randomised controlled trial: the Italian Diabetes and Exercise Study (IDES)
A Nicolucci, S Balducci, P Cardelli, S Cavallo, S Fallucca, A Bazuro, P Simonelli, C Iacobini, S Zanuso, G Pugliese, Italian Diabetes Exercise Study Investigators, Francesco Fallucca, Giuseppe Pugliese, Serena Missori, Maria Cristina Ribaudo, Elena Alessi, Paola Simonelli, Laura Salvi, Giulia Mazzitelli, Alessandra Bazuro, Felice Strollo, Massimo Morè, S Pietro, Pietro Alimonti, Nicolina Di Biase, Filomena Lasaracin, Graziano Santantonio, Laura Cruciani, Mario Manunta, Maurizio Di Mauro, Giorgio Sesti, Concetta Irace, Luigi Puccio, Mauro Cignarelli, Vincenzo Nicastro, Sabrina Piemontese, Gerardo Corigliano, Ernesto Ross, Marco Corigliano, Pierpaolo De Feo, Cristina Fatone, Cristiana Baggiore, Roberto Russo, Massimo Boemi, Luigi Lanari, Umberto Valentini, Angela Girelli, Francesca Pellicano, Paolo Mazzuca, Enrica Manicardi, Alberto Bruno, Maria Sambataro, Stefano Balducci, Antonio Pontiroli, Marco Laneri, Anna Boggio, Nunzio Zagari, Fredrick Fernando, Carla Iacobini, Stefano Menini, Gianluca Balducci, Lorella Senigagliesi, Enza Spinelli, Alessandro Di Giovanni, Mariano Pineda, Umberto Pandolfo, Ciro Giordano, Antonella Settequattrini, Marco Gambacciani, Matteo Fabrizi, Adriano Ceccherini, Enrico Balducci, Mirko Quattrini, Massimo Massarini, Giuseppe Baggio, Marco Fornari, Davide Violi, Giancarlo Cherubini, Fabio Mastelloni, Valeria Micali, Daniela Cilano, Simone Di Luciano, Davide Canevari, A Nicolucci, S Balducci, P Cardelli, S Cavallo, S Fallucca, A Bazuro, P Simonelli, C Iacobini, S Zanuso, G Pugliese, Italian Diabetes Exercise Study Investigators, Francesco Fallucca, Giuseppe Pugliese, Serena Missori, Maria Cristina Ribaudo, Elena Alessi, Paola Simonelli, Laura Salvi, Giulia Mazzitelli, Alessandra Bazuro, Felice Strollo, Massimo Morè, S Pietro, Pietro Alimonti, Nicolina Di Biase, Filomena Lasaracin, Graziano Santantonio, Laura Cruciani, Mario Manunta, Maurizio Di Mauro, Giorgio Sesti, Concetta Irace, Luigi Puccio, Mauro Cignarelli, Vincenzo Nicastro, Sabrina Piemontese, Gerardo Corigliano, Ernesto Ross, Marco Corigliano, Pierpaolo De Feo, Cristina Fatone, Cristiana Baggiore, Roberto Russo, Massimo Boemi, Luigi Lanari, Umberto Valentini, Angela Girelli, Francesca Pellicano, Paolo Mazzuca, Enrica Manicardi, Alberto Bruno, Maria Sambataro, Stefano Balducci, Antonio Pontiroli, Marco Laneri, Anna Boggio, Nunzio Zagari, Fredrick Fernando, Carla Iacobini, Stefano Menini, Gianluca Balducci, Lorella Senigagliesi, Enza Spinelli, Alessandro Di Giovanni, Mariano Pineda, Umberto Pandolfo, Ciro Giordano, Antonella Settequattrini, Marco Gambacciani, Matteo Fabrizi, Adriano Ceccherini, Enrico Balducci, Mirko Quattrini, Massimo Massarini, Giuseppe Baggio, Marco Fornari, Davide Violi, Giancarlo Cherubini, Fabio Mastelloni, Valeria Micali, Daniela Cilano, Simone Di Luciano, Davide Canevari
Abstract
Aims/hypothesis: A positive impact of exercise intervention programmes on quality of life (QoL) may be important for long-term patient compliance to exercise recommendations. We have previously shown that QoL improves significantly with supervised exercise, whereas it worsens with counselling alone, in patients with type 2 diabetes from the Italian Diabetes and Exercise Study (IDES). Here, we report data on the relationship between changes in QoL and volume of physical activity/exercise in these individuals.
Methods: This multicentre parallel randomised controlled, open-label, trial enrolled sedentary patients with type 2 diabetes (n = 606 of 691 eligible) in 22 outpatient diabetes clinics. Patients were randomised by centre, age and diabetes treatment using a permuted-block design to twice-a-week supervised aerobic and resistance training plus exercise counselling (exercise group) versus counselling alone (control group) for 12 months. Health-related QoL was assessed by the 36-Item Short Form (SF-36) Health Survey.
Results: In the exercise group (n = 268 of 303 randomised), there was a trend for increasing QoL with increasing exercise volume, with significant improvement of the physical component summary (PCS) measure only above 17.5 metabolic equivalents h⁻¹ week⁻¹ and a clear volume-relationship for the mental component summary (MCS) measure. A relationship with volume of physical activity also was observed in the control group (n = 260 of 303 randomised), despite overall deterioration of all scores. Independent correlates of improvements in both PCS and MCS were exercise volume, study arm and, inversely, baseline score.
Conclusions/interpretation: This large trial shows a relationship between changes in physical and mental health-related QoL measures and volume of physical activity/exercise, with supervised exercise training also providing volume-independent benefits.
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Source: PubMed