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Kombinationskemoterapi med eller uden strålebehandling til behandling af patienter med Hodgkins lymfom

14. juni 2023 opdateret af: Eastern Cooperative Oncology Group

Et randomiseret fase III-forsøg med ABVD versus Stanford V (+/-) strålebehandling ved lokalt omfattende og avanceret Hodgkins sygdom

RATIONALE: Lægemidler, der bruges i kemoterapi, bruger forskellige måder til at stoppe kræftceller i at dele sig, så de holder op med at vokse eller dør. Strålebehandling bruger højenergi røntgenstråler til at beskadige kræftceller. Kombination af mere end ét lægemiddel med strålebehandling kan dræbe flere kræftceller. Det vides endnu ikke, hvilken kombination af kemoterapi, der er mest effektiv til behandling af Hodgkins lymfom.

FORMÅL: Dette randomiserede fase III-forsøg studerer to forskellige kombinationskemoterapiregimer og sammenligner, hvor godt de virker, med eller uden strålebehandling, ved behandling af patienter med Hodgkins lymfom.

Studieoversigt

Status

Afsluttet

Betingelser

Lymfom

Intervention / Behandling

Detaljeret beskrivelse

MÅL:

Sammenlign den svigtfri overlevelse af patienter med lokalt omfattende eller fremskreden Hodgkins lymfom behandlet med doxorubicin, bleomycin, vinblastin og dacarbazin (ABVD) vs. doxorubicin, vinblastin, vincristin, bleomycin, mechlorethamin, etoposid og prednison) med eller uden Stan. strålebehandling.
Sammenlign den samlede overlevelse og frihed fra progression hos disse patienter 5 og 10 år efter behandling med disse regimer.
Sammenlign lungefunktion, forekomst af anden cancer, reproduktiv funktion og dødsfald af andre årsager end Hodgkins lymfom hos patienter behandlet med disse regimer.

OVERSIGT: Dette er en randomiseret undersøgelse. Patienterne stratificeres efter antallet af ugunstige risikofaktorer (0-2 vs 3-7), sygdomskarakteristika (lokalt omfattende vs fremskreden) og tidspunkt for indrejse (før addendum 6 vs. efter addendum 6). Patienterne randomiseres til 1 ud af 2 behandlingsarme.

Arm A (ABVD): Patienterne får doxorubicin (25 mg/m²), bleomycin (10 u/m²), vinblastin (6 mg/m²) og dacarbazin (375 mg/m²) IV på dag 1 og 15. Kurser gentages hver 28. dag. Patienterne genoptages efter 4 kure. Patienter, der er i fuldstændig remission, får 2 yderligere forløb. Patienter med delvis respons eller mindre evalueres efter 6 forløb, og hvis der er et løbende respons, kan patienter få 2 yderligere forløb på i alt 8. Hvis der ikke observeres noget vedvarende respons, fjernes patienterne fra undersøgelsen. Alle patienter med massiv mediastinumsygdom, uanset stadie, får strålebehandling 2-3 uger efter afslutning af kemoterapi.
Arm B (Stanford V): Patienter modtager Stanford V-kemoterapi omfattende doxorubicin (25 mg/m²) og vinblastin (6 mg/m²) IV på dag 1 i uge 1, 3, 5, 7, 9 og 11; vincristin (1,4 mg/m²) og bleomycin (5 u/m²) IV på dag 1 i uge 2, 4, 6, 8, 10 og 12; mechlorethamin (6 mg/m²) IV på dag 1 i uge 1, 5 og 9 (hvis mechlorethamin ikke er tilgængelig, kan erstattes med cyclophosphamid [375 mg/m²] IV); etoposid (60 mg/m²) IV på dag 1 og 2 i uge 3, 7 og 11; og oral prednison (40 mg/m²) hver anden dag i uge 1-9 efterfulgt af en nedtrapning. Alle patienter med omfangsrig sygdom får strålebehandling 2-3 uger efter afslutning af kemoterapi.

Patienterne følges hver 2. måned i 1 år, hver 3. måned i 1 år, hver 4. måned i 1 år, hver 6. måned i 2 år og derefter årligt.

PROJEKTERET TILSLUTNING: I alt 850 patienter vil blive akkumuleret til denne undersøgelse inden for 4,3 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

854

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 4N2
    - Tom Baker Cancer Centre - Calgary
  - Edmonton, Alberta, Canada, T6G 1Z2
    - Cross Cancer Institute at University of Alberta
- British Columbia
  - Vancouver, British Columbia, Canada, V5Z 4E6
    - British Columbia Cancer Agency - Vancouver Cancer Centre
- Manitoba
  - Winnipeg, Manitoba, Canada, R3E 0V9
    - CancerCare Manitoba
- New Brunswick
  - Saint John, New Brunswick, Canada, E2L 4L2
    - Saint John Regional Hospital
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 2Y9
    - Nova Scotia Cancer Centre
- Ontario
  - Hamilton, Ontario, Canada, L8V 5C2
    - Margaret and Charles Juravinski Cancer Centre
  - Hamilton, Ontario, Canada, ON L8N 3Z5
    - McMaster Children's Hospital at Hamilton Health Sciences
  - London, Ontario, Canada, N6A 4L6
    - London Regional Cancer Program at London Health Sciences Centre
  - St. Catharines, Ontario, Canada, L2R 5K3
    - St. Catharines General Hospital at Niagara Health System
  - Sudbury, Ontario, Canada, P3E 5J1
    - Northeastern Ontario Regional Cancer Centre
  - Thunder Bay, Ontario, Canada, P7B 6V4
    - Northwestern Ontario Regional Cancer Care at Thunder Bay Regional Health Sciences Centre
  - Toronto, Ontario, Canada, M5G 2M9
    - Princess Margaret Hospital
  - Toronto, Ontario, Canada, M4N 3M5
    - Toronto Sunnybrook Regional Cancer Centre at Sunnybrook Health Sciences Centre
- Quebec
  - Greenfield Park, Quebec, Canada, J4V 2H1
    - Hopital Charles LeMoyne
  - Montreal, Quebec, Canada, H1T 2M4
    - Maisonneuve-Rosemont Hospital
  - Montreal, Quebec, Canada, H2L 4MI
    - Centre hospitalier de l'Université de Montréal
  - Montreal, Quebec, Canada, H3G 1A4
    - McGill Cancer Centre at McGill University
  - Quebec City, Quebec, Canada, G1R 2J6
    - Centre Hospitalier Universitaire de Quebec
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4T 7T1
    - Allan Blair Cancer Centre at Pasqua Hospital
  - Saskatoon, Saskatchewan, Canada, S7N 4H4
    - Saskatoon Cancer Centre at the University of Saskatchewan
Forenede Stater
- Alabama
  - Mobile, Alabama, Forenede Stater, 36652-2144
    - Mobile Infirmary Medical Center
- Arizona
  - Phoenix, Arizona, Forenede Stater, 85013
    - St. Joseph's Hospital and Medical Center
  - Phoenix, Arizona, Forenede Stater, 85006
    - CCOP - Western Regional, Arizona
  - Tucson, Arizona, Forenede Stater, 85724-5024
    - Arizona Cancer Center at University of Arizona Health Sciences Center
- California
  - Berkeley, California, Forenede Stater, 94704
    - Alta Bates Comprehensive Cancer Center
  - Burlingame, California, Forenede Stater, 94010
    - Peninsula Medical Center
  - Castro Valley, California, Forenede Stater, 94546
    - Eden Medical Center
  - Concord, California, Forenede Stater, 94524-4110
    - Mount Diablo Regional Cancer Center
  - Fairfield, California, Forenede Stater, 94533
    - North Bay Cancer Center
  - Fremont, California, Forenede Stater, 94538
    - Kaiser Permanente - Fremont
  - Greenbrae, California, Forenede Stater, 94904
    - Marin Cancer Institute at Marin General Hospital
  - Greenbrae, California, Forenede Stater, 94904
    - Sutter Health - Western Division Cancer Research Group
  - Hayward, California, Forenede Stater, 94545
    - Saint Rose Hospital
  - Hayward, California, Forenede Stater, 94545
    - Kaiser Permanente Medical Center - Hayward
  - La Jolla, California, Forenede Stater, 92093-0658
    - Moores UCSD Cancer Center
  - Modesto, California, Forenede Stater, 95355
    - Memorial Medical Center Cancer Services
  - Oakland, California, Forenede Stater, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Forenede Stater, 94609
    - CCOP - Bay Area Tumor Institute
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente Medical Center - Oakland
  - Oakland, California, Forenede Stater, 94602
    - Highland General Hospital at St. George's University School of Medicine
  - Pleasanton, California, Forenede Stater, 94588
    - Valley Care Medical Center
  - Redwood City, California, Forenede Stater, 94063
    - Kaiser Permanente Medical Center - Redwood City
  - Richmond, California, Forenede Stater, 94801
    - Kaiser Permanente Medical Center - Richmond
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente Medical Center - Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Cancer Center at Roseville Medical Center
  - Sacramento, California, Forenede Stater, 95816
    - Sutter Cancer center
  - Sacramento, California, Forenede Stater, 95817
    - University of California Davis Cancer Center
  - Sacramento, California, Forenede Stater, 95823
    - South Sacramento Kaiser-Permanente Medical Center
  - Sacramento, California, Forenede Stater, 95825
    - Kaiser Permanente Medical Center - Sacramento
  - Salinas, California, Forenede Stater, 93901
    - Salinas Valley Memorial Hospital
  - San Diego, California, Forenede Stater, 92161
    - Veterans Affairs Medical Center - San Diego
  - San Diego, California, Forenede Stater, 92120
    - Kaiser Permanente Medical Office -Vandever Medical Office
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente Medical Center - San Francisco Geary Campus
  - San Francisco, California, Forenede Stater, 94118
    - California Pacific Medical Center - California Campus
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente Medical Center - Santa Teresa
  - San Pablo, California, Forenede Stater, 94806
    - J.C. Robinson, M.D. Regional Cancer Center
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser Foundation Hospital - San Rafael
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara Kiely Campus
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente Medical Center - Santa Rosa
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente Medical Center - South San Francisco
  - Stockton, California, Forenede Stater, 95210
    - Kaiser Permanente Medical Facility - Stockton
  - Vallejo, California, Forenede Stater, 94589
    - Sutter Solano Medical Center
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente Medical Center - Vallejo
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente Medical Center - Walnut Creek
  - Walnut Creek, California, Forenede Stater, 94598
    - John Muir/Mt. Diablo Comprehensive Cancer Center
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - Aurora Presbyterian Hospital
  - Boulder, Colorado, Forenede Stater, 80301-9019
    - Boulder Community Hospital
  - Colorado Springs, Colorado, Forenede Stater, 80933
    - Penrose Cancer Center at Penrose Hospital
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - Memorial Hospital
  - Denver, Colorado, Forenede Stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - St. Luke's Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - St. Joseph Hospital
  - Denver, Colorado, Forenede Stater, 80224-2522
    - CCOP - Colorado Cancer Research Program, Incorporated
  - Englewood, Colorado, Forenede Stater, 80110
    - Swedish Medical Center
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Front Range Cancer Specialists
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Longmont, Colorado, Forenede Stater, 80502
    - Hope Cancer Care Center at Longmont United Hospital
  - Pueblo, Colorado, Forenede Stater, 81004
    - St. Mary-Corwin Regional Medical Center
  - Thornton, Colorado, Forenede Stater, 80229
    - North Suburban Medical Center
- Delaware
  - Lewes, Delaware, Forenede Stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19713
    - CCOP - Christiana Care Health Services
  - Wilmington, Delaware, Forenede Stater, 19805
    - St. Francis Hospital
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20007
    - Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
  - Washington, District of Columbia, Forenede Stater, 20307-5001
    - Walter Reed Army Medical Center
- Florida
  - Fort Lauderdale, Florida, Forenede Stater, 33316
    - Broward General Medical Center Cancer Center
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
  - Hollywood, Florida, Forenede Stater, 33021
    - Memorial Cancer Institute at Memorial Regional Hospital
  - Jacksonville, Florida, Forenede Stater, 32224
    - Mayo Clinic - Jacksonville
  - Jupiter, Florida, Forenede Stater, 33458
    - Ella Milbank Foshay Cancer Center at Jupiter Medical Center
  - Miami, Florida, Forenede Stater, 33136
    - University of Miami Sylvester Comprehensive Cancer Center
  - Miami Beach, Florida, Forenede Stater, 33140
    - CCOP - Mount Sinai Medical Center
  - Orlando, Florida, Forenede Stater, 32806
    - M.D. Anderson Cancer Center - Orlando
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30322
    - Winship Cancer Institute of Emory University
  - Atlanta, Georgia, Forenede Stater, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, Forenede Stater, 30342-1611
    - Northside Hospital Cancer Center
  - Atlanta, Georgia, Forenede Stater, 30342-1701
    - Saint Joseph's Hospital of Atlanta
  - Atlanta, Georgia, Forenede Stater, 30342
    - CCOP - Atlanta Regional
  - Austell, Georgia, Forenede Stater, 30106
    - WellStar Cobb Hospital
  - Decatur, Georgia, Forenede Stater, 30033
    - Charles B. Eberhart Cancer Center at DeKalb Medical Center
  - Decatur, Georgia, Forenede Stater, 30033
    - Veterans Affairs Medical Center - Atlanta (Decatur)
  - Lawrenceville, Georgia, Forenede Stater, 30045
    - Gwinnett Medical Center
  - Marietta, Georgia, Forenede Stater, 30060
    - Kennestone Cancer Center at Wellstar Kennestone Hospital
  - Riverdale, Georgia, Forenede Stater, 30274-2600
    - Southern Regional Medical Center
  - Savannah, Georgia, Forenede Stater, 31403-3089
    - Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
- Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96859
    - Tripler Army Medical Center
- Idaho
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
  - Boise, Idaho, Forenede Stater, 83712
    - St. Luke's Mountain States Tumor Institute - Boise
- Illinois
  - Alton, Illinois, Forenede Stater, 62002
    - Saint Anthony's Hospital at Saint Anthony's Health Center
  - Aurora, Illinois, Forenede Stater, 60507
    - Rush-Copley Cancer Care Center
  - Bloomington, Illinois, Forenede Stater, 61701
    - St. Joseph Medical Center
  - Canton, Illinois, Forenede Stater, 61520
    - Graham Hospital
  - Carthage, Illinois, Forenede Stater, 62321
    - Memorial Hospital
  - Chicago, Illinois, Forenede Stater, 60612
    - Rush University Medical Center
  - Chicago, Illinois, Forenede Stater, 60637-1470
    - University of Chicago Cancer Research Center
  - Chicago, Illinois, Forenede Stater, 60611-3013
    - Robert H. Lurie Comprehensive Cancer Center at Northwestern University
  - Chicago, Illinois, Forenede Stater, 60625
    - Swedish Covenant Hospital
  - Chicago, Illinois, Forenede Stater, 60611
    - Hematology and Oncology Associates
  - Chicago, Illinois, Forenede Stater, 60611
    - Veterans Affairs Medical Center - Lakeside Chicago
  - Chicago, Illinois, Forenede Stater, 60616
    - Mercy Hospital and Medical Center
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital Cancer Care Institute
  - Eureka, Illinois, Forenede Stater, 61530
    - Eureka Community Hospital
  - Evanston, Illinois, Forenede Stater, 60201-1781
    - Evanston Northwestern Health Care - Evanston Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Galesburg Cottage Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Galesburg Clinic
  - Galesburg, Illinois, Forenede Stater, 61401
    - InterCommunity Cancer Center of Western Illinois
  - Harvey, Illinois, Forenede Stater, 60426
    - Ingalls Cancer Care Center at Ingalls Memorial Hospital
  - Havana, Illinois, Forenede Stater, 62644
    - Mason District Hospital
  - Hinsdale, Illinois, Forenede Stater, 60521
    - Hinsdale Hematology Oncology Associates
  - Hopedale, Illinois, Forenede Stater, 61747
    - Hopedale Medical Complex
  - Joliet, Illinois, Forenede Stater, 60435
    - Joliet Oncology-Hematology Associates, Limited - West
  - Joliet, Illinois, Forenede Stater, 60432
    - Midwest Center for Hematology/Oncology
  - Kewanee, Illinois, Forenede Stater, 61443
    - Kewanee Hospital
  - Libertyville, Illinois, Forenede Stater, 60048
    - North Shore Oncology and Hematology Associates, Limited - Libertyville
  - Macomb, Illinois, Forenede Stater, 61455
    - Mcdonough District Hospital
  - Maywood, Illinois, Forenede Stater, 60153
    - Cardinal Bernardin Cancer Center at Loyola University Medical Center
  - Moline, Illinois, Forenede Stater, 61265
  - Moline, Illinois, Forenede Stater, 61265
    - Trinity Medical Center - East
  - Mount Vernon, Illinois, Forenede Stater, 62864
    - Good Samaritan Regional Health Center
  - Naperville, Illinois, Forenede Stater, 60540
    - Edward Hospital Cancer Center
  - Naperville, Illinois, Forenede Stater, 60540
    - Hematology Oncology Consultants - Naperville
  - Niles, Illinois, Forenede Stater, 60714
    - Northwest Medical Specialist, PC
  - Normal, Illinois, Forenede Stater, 61761
    - Bromenn Regional Medical Center
  - Normal, Illinois, Forenede Stater, 61761
    - Community Cancer Center
  - Ottawa, Illinois, Forenede Stater, 61350
    - Community Hospital of Ottawa
  - Ottawa, Illinois, Forenede Stater, 61350
    - Oncology Hematology Associates of Central Illinois, PC - Ottawa
  - Pekin, Illinois, Forenede Stater, 61554
    - Cancer Treatment Center at Pekin Hospital
  - Peoria, Illinois, Forenede Stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forenede Stater, 61614
    - Proctor Hospital
  - Peoria, Illinois, Forenede Stater, 61637
    - OSF St. Francis Medical Center
  - Peoria, Illinois, Forenede Stater, 61615
    - CCOP - Illinois Oncology Research Association
  - Peoria, Illinois, Forenede Stater, 61615
    - Oncology Hematology Associates of Central Illinois, PC - Peoria
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois Valley Community Hospital
  - Princeton, Illinois, Forenede Stater, 61356
    - Perry Memorial Hospital
  - Rockford, Illinois, Forenede Stater, 61104-2315
    - Swedish-American Regional Cancer Center
  - Skokie, Illinois, Forenede Stater, 60076
    - Hematology Oncology Associates - Skokie
  - Skokie, Illinois, Forenede Stater, 60077
    - Midwest Cancer Research Group, Incorporated
  - Skokie, Illinois, Forenede Stater, 60076
    - Hematology/Oncology of the North Shore at Gross Point Medical Center
  - Spring Valley, Illinois, Forenede Stater, 61362
    - St. Margaret's Hospital
  - Spring Valley, Illinois, Forenede Stater, 61362
    - Valley Cancer Center
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center at Carle Foundation Hospital
  - Urbana, Illinois, Forenede Stater, 61801
    - CCOP - Carle Cancer Center
- Indiana
  - Beech Grove, Indiana, Forenede Stater, 46107
    - St. Francis Hospital and Health Centers - Beech Grove Campus
  - Elkhart, Indiana, Forenede Stater, 46515
    - Elkhart General Hospital
  - Fort Wayne, Indiana, Forenede Stater, 46815
    - Fort Wayne Medical Oncology and Hematology
  - Kokomo, Indiana, Forenede Stater, 46904
    - Howard Community Hospital at Howard Regional Health System
  - La Porte, Indiana, Forenede Stater, 46350
    - Center for Cancer Therapy at LaPorte Hospital and Health Services
  - Michigan City, Indiana, Forenede Stater, 46360
    - Saint Anthony Memorial Health Centers
  - Muncie, Indiana, Forenede Stater, 47303
    - Medical Consultants, P. C. at Ball Cancer Center
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Hospital & Health Care Services, Incorporated
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forenede Stater, 46601
    - CCOP - Northern Indiana CR Consortium
  - South Bend, Indiana, Forenede Stater, 46617
    - Saint Joseph Regional Medical Center
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic, P. C.
  - Bettendorf, Iowa, Forenede Stater, 52722
  - Cedar Rapids, Iowa, Forenede Stater, 52402
    - St. Luke's Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Cedar Rapids Oncology Associates
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Mercy Regional Cancer Center at Mercy Medical Center
  - Davenport, Iowa, Forenede Stater, 52804
    - Genesis Medical Center - West Campus
  - Davenport, Iowa, Forenede Stater, 52803
    - Genesis Regional Cancer Center at Genesis Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - CCOP - Iowa Oncology Research Association
  - Des Moines, Iowa, Forenede Stater, 50309
    - John Stoddard Cancer Center at Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - Medical Oncology and Hematology Associates at John Stoddard Cancer Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Medical Oncology and Hematology Associates at Mercy Cancer Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Cancer Center at Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50307
    - Mercy Capitol Hospital
  - Des Moines, Iowa, Forenede Stater, 50316-2301
    - John Stoddard Cancer Center at Iowa Lutheran Hospital
  - Iowa City, Iowa, Forenede Stater, 52242
    - Holden Comprehensive Cancer Center at University of Iowa
  - Onawa, Iowa, Forenede Stater, 51040
    - Burgess Health Center
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Regional Cancer Center
  - Sioux City, Iowa, Forenede Stater, 51104
    - St. Luke's Regional Medical Center
  - Sioux City, Iowa, Forenede Stater, 51104
    - Mercy Medical Center - Sioux City
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Hematology-Oncology Associates
  - West Des Moines, Iowa, Forenede Stater, 50266
    - Medical Oncology and Hematology Associates - West Des Moines
- Kansas
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas, P.A. - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas, PA - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas, P.A. - El Dorado
  - Kansas City, Kansas, Forenede Stater, 66160-7357
    - Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas, P.A. - Kingman
  - Liberal, Kansas, Forenede Stater, 67901
    - Southwest Medical Center
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas, P.A. - Newton
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas, P.A. - Parsons
  - Pratt, Kansas, Forenede Stater, 67124
    - Cancer Center of Kansas, P.A. - Pratt
  - Salina, Kansas, Forenede Stater, 67401
    - Salina Regional Health Center
  - Salina, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas, P.A. - Salina
  - Topeka, Kansas, Forenede Stater, 66606
    - St. Francis Comprehensive Cancer Center
  - Topeka, Kansas, Forenede Stater, 66604
    - Stormont-Vail Cancer Center
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas, P.A. - Wellington
  - Wichita, Kansas, Forenede Stater, 67214
    - Wesley Medical Center
  - Wichita, Kansas, Forenede Stater, 67214
    - CCOP - Wichita
  - Wichita, Kansas, Forenede Stater, 67214
    - Via Christi Cancer Center at Via Christi Regional Medical Center
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas, P.A. - Wichita
  - Wichita, Kansas, Forenede Stater, 67203
    - Associates in Womens Health, P.A. - North Review
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas, P.A. - Medical Arts Tower
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas, P.A. - Winfield
- Kentucky
  - Louisville, Kentucky, Forenede Stater, 40202
    - James Graham Brown Cancer Center at University of Louisville
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Mary Bird Perkins Cancer Center - Baton Rouge
  - Baton Rouge, Louisiana, Forenede Stater, 708169990
    - Ochsner Clinic of Baton Rouge
  - Baton Rouge, Louisiana, Forenede Stater, 70806
    - Pennington Cancer Center at Baton Rouge General
  - Houma, Louisiana, Forenede Stater, 70360
    - Terrebonne General Medical Center
  - Monroe, Louisiana, Forenede Stater, 71210
    - Louisiana State University Health Sciences Center - Monroe
  - New Orleans, Louisiana, Forenede Stater, 70121
    - CCOP - Ochsner
  - New Orleans, Louisiana, Forenede Stater, 70112
    - MBCCOP - LSU Health Sciences Center
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Cancer Institute at Ochsner Clinic Foundation
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Medical Center of Louisiana - New Orleans
  - Shreveport, Louisiana, Forenede Stater, 71130-3932
    - Feist-Weiller Cancer Center at Louisiana State University Health Sciences
  - Shreveport, Louisiana, Forenede Stater, 71101
    - Veterans Affairs Medical Center - Shreveport
- Maine
  - Bangor, Maine, Forenede Stater, 04401
    - CancerCare of Maine at Eastern Maine Medial Center
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21231-2410
    - Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  - Baltimore, Maryland, Forenede Stater, 21201
    - Greenebaum Cancer Center at University of Maryland Medical Center
  - Elkton, Maryland, Forenede Stater, 21921
    - Union Hospital Cancer Center at Union Hospital
- Massachusetts
  - Attleboro, Massachusetts, Forenede Stater, 02703
    - Sturdy Memorial Hospital
  - Boston, Massachusetts, Forenede Stater, 02118
    - Cancer Research Center at Boston Medical Center
  - Boston, Massachusetts, Forenede Stater, 02111
    - TUFTS - New England Medical Center
  - Greenfield, Massachusetts, Forenede Stater, 01301
    - Franklin Medical Center
  - Springfield, Massachusetts, Forenede Stater, 01199
    - Baystate Regional Cancer Program at D'Amour Center for Cancer Care
- Michigan
  - Adrian, Michigan, Forenede Stater, 49221
    - Hickman Cancer Center at Bixby Medical Center
  - Ann Arbor, Michigan, Forenede Stater, 48109-0942
    - University of Michigan Comprehensive Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - CCOP - Michigan Cancer Research Consortium
  - Ann Arbor, Michigan, Forenede Stater, 48106-0995
    - St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Battle Creek Health System Cancer Care Center
  - Bay City, Michigan, Forenede Stater, 48708
    - Bay Regional Medical Center
  - Big Rapids, Michigan, Forenede Stater, 49307
    - Mecosta County Medical Center
  - Dearborn, Michigan, Forenede Stater, 48123-2500
    - Oakwood Cancer Center at Oakwood Hospital and Medical Center
  - Detroit, Michigan, Forenede Stater, 48202
    - Josephine Ford Cancer Center at Henry Ford Hospital
  - Escanaba, Michigan, Forenede Stater, 49431
    - Green Bay Oncology, Limited - Escanaba
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - CCOP - Grand Rapids
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Lacks Cancer Center at Saint Mary's Mercy Medical Center
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Spectrum Health Cancer Care - Butterworth Campus
  - Grand Rapids, Michigan, Forenede Stater, 49506
    - Metropolitan Hospital
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Van Elslander Cancer Center at St. John Hospital and Medical Center
  - Holland, Michigan, Forenede Stater, 49423
    - Holland Community Hospital
  - Iron Mountain, Michigan, Forenede Stater, 49801
    - Green Bay Oncology, Limited - Iron Mountain
  - Jackson, Michigan, Forenede Stater, 49201
    - Foote Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49001
    - Borgess Medical Center
  - Kalamazoo, Michigan, Forenede Stater, 49007-3731
    - West Michigan Cancer Center
  - Lambertville, Michigan, Forenede Stater, 48144
    - Haematology-Oncology Associates of Ohio and Michigan, P.C.
  - Lansing, Michigan, Forenede Stater, 48910
    - Breslin Cancer Center at Ingham Regional Medical Center
  - Lansing, Michigan, Forenede Stater, 48909
    - Sparrow Regional Cancer Center
  - Marquette, Michigan, Forenede Stater, 49855
    - Upper Michigan Cancer Center at Marquette General Hospital
  - Monroe, Michigan, Forenede Stater, 48162
    - Community Cancer Center of Monroe
  - Monroe, Michigan, Forenede Stater, 48162
    - Mercy Memorial Hospital System
  - Muskegon, Michigan, Forenede Stater, 49443
    - Hackley Hospital
  - Petoskey, Michigan, Forenede Stater, 49770
    - Northern Michigan Hospital
  - Royal Oak, Michigan, Forenede Stater, 48073
    - William Beaumont Hospital - Royal Oak Campus
  - Saginaw, Michigan, Forenede Stater, 48601
    - Seton Cancer Institute - Saginaw
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph
  - Southfield, Michigan, Forenede Stater, 48075
    - Providence Cancer Institute at Providence Hospital - Southfield Campus
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Warren, Michigan, Forenede Stater, 48093
    - St. John Macomb Hospital
- Minnesota
  - Alexandria, Minnesota, Forenede Stater, 56308
  - Bemidji, Minnesota, Forenede Stater, 56601
    - MeritCare Clinic - Bemidji
  - Brainerd, Minnesota, Forenede Stater, 56401
    - Brainerd Medical Center
  - Brainerd, Minnesota, Forenede Stater, 56401
    - St. Joseph's Medical Center
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy and Unity Cancer Center at Mercy Hospital
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Fergus Falls, Minnesota, Forenede Stater, 56537
  - Fridley, Minnesota, Forenede Stater, 55432
    - Mercy and Unity Cancer Center at Unity Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
  - Montevideo, Minnesota, Forenede Stater, 56265
    - Chippewa County - Montevideo Hospital
  - Robbinsdale, Minnesota, Forenede Stater, 55422-2900
    - Hubert H. Humphrey Cancer Center at North Memorial Medical Center
  - Rochester, Minnesota, Forenede Stater, 55905
    - Mayo Clinic Cancer Center
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - CentraCare Clinic - River Campus
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Coborn Cancer Center
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - CCOP - Metro-Minnesota
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Health Services
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
- Mississippi
  - Hattiesburg, Mississippi, Forenede Stater, 39401
    - Hattiesburg Clinic, P.A.
  - Jackson, Mississippi, Forenede Stater, 39216-4505
    - University of Mississippi Medical Center
- Missouri
  - Cape Girardeau, Missouri, Forenede Stater, 63701
    - Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
  - Cape Girardeau, Missouri, Forenede Stater, 63701
    - Saint Francis Medical Center
  - Columbia, Missouri, Forenede Stater, 65203
    - Ellis Fischel Cancer Center at University of Missouri - Columbia
  - Saint Louis, Missouri, Forenede Stater, 63141
    - CCOP - St. Louis-Cape Girardeau
  - Saint Louis, Missouri, Forenede Stater, 63141
    - David C. Pratt Cancer Center at St. John's Mercy
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Siteman Cancer Center at Barnes-Jewish Hospital
  - Springfield, Missouri, Forenede Stater, 65802
    - CCOP - Cancer Research for the Ozarks
  - Springfield, Missouri, Forenede Stater, 65804
    - St. John's Regional Health Center
  - Springfield, Missouri, Forenede Stater, 65807
    - Hulston Cancer Center at Cox Medical Center South
- Montana
  - Billings, Montana, Forenede Stater, 59101
    - CCOP - Montana Cancer Consortium
  - Billings, Montana, Forenede Stater, 59101
    - Hematology-Oncology Centers of the Northern Rockies - Billings
  - Billings, Montana, Forenede Stater, 59101
    - Northern Rockies Radiation Oncology Center
  - Billings, Montana, Forenede Stater, 59101
    - St. Vincent Healthcare
  - Billings, Montana, Forenede Stater, 59107-7000
    - Deaconess Billings Clinic - Downtown
  - Billings, Montana, Forenede Stater, 59107-5100
    - Deaconess Billings Clinic Cancer Center
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Hospital
  - Bozeman, Montana, Forenede Stater, 59715
    - Internal Medicine Associates of Bozeman
  - Butte, Montana, Forenede Stater, 59701
    - St. James Community Hospital
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forenede Stater, 59405
    - Big Sky Oncology
  - Great Falls, Montana, Forenede Stater, 59405
    - Sletten Regional Cancer Institute
  - Helena, Montana, Forenede Stater, 59601
    - St. Peter's Hospital
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
  - Kalispell, Montana, Forenede Stater, 59901
    - Glacier Oncology, PLLC
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Medical Oncology
  - Missoula, Montana, Forenede Stater, 59801
    - Community Medical Center
  - Missoula, Montana, Forenede Stater, 59807-7877
    - Montana Cancer Specialists at Montana Cancer Center
  - Missoula, Montana, Forenede Stater, 59807
    - Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
- Nebraska
  - Grand Island, Nebraska, Forenede Stater, 68803
    - Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center
  - Lincoln, Nebraska, Forenede Stater, 68502
    - Bryan LGH Medical Center West
  - Lincoln, Nebraska, Forenede Stater, 68510
    - St. Elizabeth Regional Medical Center
  - North Platte, Nebraska, Forenede Stater, 69101-6598
    - Great Plains Regional Medical Center
  - Omaha, Nebraska, Forenede Stater, 68198-6805
    - UNMC Eppley Cancer Center at the University of Nebraska Medical Center
  - Omaha, Nebraska, Forenede Stater, 68122
    - Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68131-2197
    - Creighton University Medical Center
  - Omaha, Nebraska, Forenede Stater, 68124
    - Bergan Mercy Medical Center
- Nevada
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - CCOP - Nevada Cancer Research Foundation
- New Hampshire
  - Hooksett, New Hampshire, Forenede Stater, 03106
    - New Hampshire Oncology-Hematology, PA - Hooksett
  - Keene, New Hampshire, Forenede Stater, 03431
    - Kingsbury Center for Cancer Care at Cheshire Medical Center
  - Lebanon, New Hampshire, Forenede Stater, 03756-0002
    - Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
  - Manchester, New Hampshire, Forenede Stater, 03103
    - Elliot Regional Cancer Center
  - Rochester, New Hampshire, Forenede Stater, 03867
    - Frisbie Memorial Hospital
- New Jersey
  - Hamilton, New Jersey, Forenede Stater, 08690
    - Cancer Institute of New Jersey at Hamilton
  - Livingston, New Jersey, Forenede Stater, 07039
    - St. Barnabas Medical Center
  - Marlton, New Jersey, Forenede Stater, 08053
    - Fox Chase Virtua Health Cancer Program - Marlton
  - Montclair, New Jersey, Forenede Stater, 07042
    - Mountainside Hospital Cancer Center
  - Morristown, New Jersey, Forenede Stater, 07962
    - Carol G. Simon Cancer Center at Morristown Memorial Hospital
  - New Brunswick, New Jersey, Forenede Stater, 08903
    - Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
  - Red Bank, New Jersey, Forenede Stater, 07701
    - Booker Cancer Center at Riverview Medical Center
  - Trenton, New Jersey, Forenede Stater, 08629
    - Fox Chase Cancer Center at St. Francis Medical Center
  - Voorhees, New Jersey, Forenede Stater, 08043
    - Cancer Institute of New Jersey at Cooper - Voorhees
  - Voorhees, New Jersey, Forenede Stater, 08043
    - Fox Chase Virtua Health Cancer Program at Virtua West Jersey
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87131-5636
    - University of New Mexico Cancer Research and Treatment Center
- New York
  - Bronx, New York, Forenede Stater, 10461
    - Albert Einstein Cancer Center at Albert Einstein College of Medicine
  - Bronx, New York, Forenede Stater, 10466
    - Our Lady of Mercy Medical Center Comprehensive Cancer Center
  - Clifton Springs, New York, Forenede Stater, 14432
    - Finger Lakes Hematology and Oncology
  - Glens Falls, New York, Forenede Stater, 12801
    - Adirondack Cancer Care - Glens Falls
  - Glens Falls, New York, Forenede Stater, 12801
    - Charles R. Wood Cancer Center at Glens Falls Hospital
  - New York, New York, Forenede Stater, 10021
    - Memorial Sloan-Kettering Cancer Center
  - New York, New York, Forenede Stater, 10011
    - St. Vincent's Comprehensive Cancer Center - Manhattan
  - Oswego, New York, Forenede Stater, 13126
    - Oswego Hospital
  - Rochester, New York, Forenede Stater, 14642
    - James P. Wilmot Cancer Center at University of Rochester Medical Center
  - Rochester, New York, Forenede Stater, 14620
    - Highland Hospital of Rochester
  - Syracuse, New York, Forenede Stater, 13210
    - SUNY Upstate Medical University Hospital
  - Syracuse, New York, Forenede Stater, 13215
    - Community General Hospital of Greater Syracuse
  - Syracuse, New York, Forenede Stater, 13057
    - CCOP - Hematology-Oncology Associates of Central New York
- North Carolina
  - Asheville, North Carolina, Forenede Stater, 28801
    - Mission Hospitals - Memorial Campus
  - Chapel Hill, North Carolina, Forenede Stater, 27599-7295
    - Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
  - Charlotte, North Carolina, Forenede Stater, 28232-2861
    - Blumenthal Cancer Center at Carolinas Medical Center
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Radiation Oncology
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital, Incorporated
  - Greenville, North Carolina, Forenede Stater, 27835-6028
    - Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital
  - Kinston, North Carolina, Forenede Stater, 28501
    - Lenoir Memorial Cancer Center
  - Statesville, North Carolina, Forenede Stater, 28677
    - Iredell Memorial Hospital
  - Wilson, North Carolina, Forenede Stater, 27893-3428
    - Wilson Medical Center
  - Winston-Salem, North Carolina, Forenede Stater, 27157-1096
    - Wake Forest University Comprehensive Cancer Center
  - Winston-Salem, North Carolina, Forenede Stater, 27103
    - Forsyth Regional Cancer Center at Forsyth Medical Center
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Bismarck Cancer Center
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Cancer Care Center at Medcenter One Hospital
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Mid Dakota Clinic, P. C.
  - Bismarck, North Dakota, Forenede Stater, 58502
    - St. Alexius Medical Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - CCOP - MeritCare Hospital
  - Fargo, North Dakota, Forenede Stater, 58122
    - MeritCare Medical Group
- Ohio
  - Akron, Ohio, Forenede Stater, 44307
    - McDowell Cancer Center at Akron General Medical Center
  - Akron, Ohio, Forenede Stater, 44309-2090
    - Akron City Hospital
  - Bowling Green, Ohio, Forenede Stater, 43402
    - Wood County Oncology Center
  - Canton, Ohio, Forenede Stater, 44710-1799
    - Aultman Hospital Cancer Center at Aultman Health Foundation
  - Canton, Ohio, Forenede Stater, 44708
    - Mercy Cancer Center at Mercy Medical Center
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45267
    - Charles M. Barrett Cancer Center at University Hospital
  - Cincinnati, Ohio, Forenede Stater, 45229
    - Jewish Hospital Cancer Center
  - Cleveland, Ohio, Forenede Stater, 44195
    - Cleveland Clinic Taussig Cancer Center
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth's Cancer Care Center at MetroHealth Medical Center
  - Cleveland, Ohio, Forenede Stater, 44106
    - Case Comprehensive Cancer Center
  - Columbus, Ohio, Forenede Stater, 43210-1240
    - Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
  - Columbus, Ohio, Forenede Stater, 43214-3998
    - Riverside Methodist Hospital Cancer Care
  - Columbus, Ohio, Forenede Stater, 43215
    - CCOP - Columbus
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital at Ohio Health
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Riverside Cancer Services
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel West Hospital
  - Dayton, Ohio, Forenede Stater, 45428
    - Veterans Affairs Medical Center - Dayton
  - Dayton, Ohio, Forenede Stater, 45405
    - Grandview Hospital
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital
  - Dayton, Ohio, Forenede Stater, 45409
    - David L. Rike Cancer Center at Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Samaritan North Cancer Care Center
  - Dayton, Ohio, Forenede Stater, 45429
    - CCOP - Dayton
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Medical Associates
  - Fremont, Ohio, Forenede Stater, 43420
    - Fremont Memorial Hospital
  - Independence, Ohio, Forenede Stater, 44131
    - Community Oncology Group at Cleveland Clinic Cancer Center
  - Kenton, Ohio, Forenede Stater, 43326
    - Kenton Oncology, Incorporated
  - Kettering, Ohio, Forenede Stater, 45429
    - Charles F. Kettering Memorial Hospital
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Forenede Stater, 45804
    - Lima Memorial Hospital
  - Lima, Ohio, Forenede Stater, 45801
    - St. Rita's Medical Center
  - Marietta, Ohio, Forenede Stater, 45750
    - Strecker Cancer Center at Marietta Memorial Hospital
  - Maumee, Ohio, Forenede Stater, 43537
    - Northwest Ohio Oncology Center
  - Maumee, Ohio, Forenede Stater, 43537
    - St. Luke's Hospital
  - Middletown, Ohio, Forenede Stater, 45044
    - Middletown Regional Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Cancer Care Program at Licking Memorial Hospital
  - Oregon, Ohio, Forenede Stater, 43616
    - St. Charles Mercy Hospital
  - Oregon, Ohio, Forenede Stater, 43616
    - Toledo Clinic - Oregon
  - Sandusky, Ohio, Forenede Stater, 44870
    - Firelands Regional Medical Center
  - Sandusky, Ohio, Forenede Stater, 44870
    - North Coast Cancer Care, Incorporated
  - Springfield, Ohio, Forenede Stater, 45505
    - Community Hospital of Springfield and Clark County
  - Springfield, Ohio, Forenede Stater, 45504
    - Mercy Medical Center
  - Sylvania, Ohio, Forenede Stater, 43560
    - Promedica Cancer Center at Flower Hospital
  - Tiffin, Ohio, Forenede Stater, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, Forenede Stater, 43608
    - St. Vincent Mercy Medical Center
  - Toledo, Ohio, Forenede Stater, 43606
    - Toledo Hospital
  - Toledo, Ohio, Forenede Stater, 43614
    - Medical University of Ohio Cancer Center
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Clinic, Incorporated - Main Clinic
  - Toledo, Ohio, Forenede Stater, 43623
    - CCOP - Toledo Community Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Surgical Specialists
  - Troy, Ohio, Forenede Stater, 45373-1300
    - UVMC Cancer Care Center at Upper Valley Medical Center
  - Wauseon, Ohio, Forenede Stater, 43567
    - Fulton County Health Center
  - Westerville, Ohio, Forenede Stater, 43081
    - Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital
  - Wooster, Ohio, Forenede Stater, 44691
    - Cleveland Clinic - Wooster
  - Xenia, Ohio, Forenede Stater, 45385
    - Ruth G. McMillan Cancer Center at Greene Memorial Hospital
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis - Good Samaritan Hospital
- Oklahoma
  - Lawton, Oklahoma, Forenede Stater, 73505
    - Comanche County Memorial Hospital
  - Tulsa, Oklahoma, Forenede Stater, 74136
    - Natalie Warren Bryant Cancer Center at St. Francis Hospital
  - Tulsa, Oklahoma, Forenede Stater, 74104
    - LaFortune Cancer Center at St. John Medical Center
- Oregon
  - Gresham, Oregon, Forenede Stater, 97030
    - Legacy Mount Hood Medical Center
  - Milwaukie, Oregon, Forenede Stater, 97222
    - Providence Milwaukie Hospital
  - Portland, Oregon, Forenede Stater, 97213-2967
    - Providence Cancer Center at Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - CCOP - Columbia River Oncology Program
  - Portland, Oregon, Forenede Stater, 97225
    - Providence St. Vincent Medical Center
  - Portland, Oregon, Forenede Stater, 97210
    - Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer Center
  - Portland, Oregon, Forenede Stater, 97227
    - Legacy Emanuel Hospital and Health Center & Children's Hospital
  - Portland, Oregon, Forenede Stater, 97232
    - Kaiser Permanente Health Care - Portland
  - Tualatin, Oregon, Forenede Stater, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Allentown, Pennsylvania, Forenede Stater, 18105
    - Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Drexel Hill, Pennsylvania, Forenede Stater, 19026
    - Delaware County Regional Cancer Center at Delaware County Memorial Hospital
  - Hershey, Pennsylvania, Forenede Stater, 17033-0850
    - Penn State Cancer Institute at Milton S. Hershey Medical Center
  - Langhorne, Pennsylvania, Forenede Stater, 19047
    - St. Mary Regional Cancer Center
  - Paoli, Pennsylvania, Forenede Stater, 19301-1792
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19104-4283
    - Abramson Cancer Center of The University of Pennsylvania
  - Philadelphia, Pennsylvania, Forenede Stater, 19111-2497
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Joan Karnell Cancer Center at Pennsylvania Hospital
  - Scranton, Pennsylvania, Forenede Stater, 18501
    - Mercy Hospital Cancer Center - Scranton
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Hematology and Oncology Associates
  - West Chester, Pennsylvania, Forenede Stater, 19380
    - Chester County Hospital
  - West Grove, Pennsylvania, Forenede Stater, 19390-9499
    - Jennersville Regional Hospital
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - CCOP - MainLine Health
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Cancer Center at Lankenau Hospital
- South Carolina
  - Charleston, South Carolina, Forenede Stater, 29425
    - Hollings Cancer Center at Medical University of South Carolina
  - Greenville, South Carolina, Forenede Stater, 29615
    - CCOP - Greenville
  - Greenville, South Carolina, Forenede Stater, 29601
    - Bon Secours St. Francis Health System
- South Dakota
  - Aberdeen, South Dakota, Forenede Stater, 57401
    - Oncology Services of Aberdeen
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5039
    - Sioux Valley Hospital and University of South Dakota Medical Center
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Medical X-Ray Center, PC
- Tennessee
  - Kingsport, Tennessee, Forenede Stater, 37662
    - Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
  - Knoxville, Tennessee, Forenede Stater, 37916
    - Thompson Cancer Survival Center
  - Knoxville, Tennessee, Forenede Stater, 37901
    - Baptist Regional Cancer Center at Baptist Hospital of East Tennessee
  - Nashville, Tennessee, Forenede Stater, 37232
    - Vanderbilt-Ingram Cancer Center
- Texas
  - Fort Sam Houston, Texas, Forenede Stater, 78234
    - Brooke Army Medical Center
  - Lackland Air Force Base, Texas, Forenede Stater, 78236
    - Wilford Hall Medical Center
  - Laredo, Texas, Forenede Stater, 78041
    - Doctor's Hospital of Laredo
  - Lubbock, Texas, Forenede Stater, 79415-3364
    - UMC Southwest Cancer and Research Center
  - San Antonio, Texas, Forenede Stater, 78229
    - Cancer Therapy and Research Center
  - San Antonio, Texas, Forenede Stater, 78209
    - Veterans Affairs Medical Center - San Antonio (Murphy)
  - San Antonio, Texas, Forenede Stater, 78229-3900
    - University of Texas Health Science Center at San Antonio
  - San Antonio, Texas, Forenede Stater, 78229
    - University Hospital - San Antonio
  - Temple, Texas, Forenede Stater, 76508
    - CCOP - Scott and White Hospital
- Utah
  - American Fork, Utah, Forenede Stater, 84003
    - American Fork Hospital
  - Logan, Utah, Forenede Stater, 84321
    - Logan Regional Hospital
  - Murray, Utah, Forenede Stater, 84107
    - Cottonwood Hospital Medical Center
  - Ogden, Utah, Forenede Stater, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, Forenede Stater, 84604
    - Utah Valley Regional Medical Center - Provo
  - Saint George, Utah, Forenede Stater, 84770
    - Dixie Regional Medical Center - East Campus
  - Salt Lake City, Utah, Forenede Stater, 84143
    - LDS Hospital
  - Salt Lake City, Utah, Forenede Stater, 84112
    - Huntsman Cancer Institute at University of Utah
  - Salt Lake City, Utah, Forenede Stater, 84106
    - Utah Cancer Specialists at UCS Cancer Center
- Vermont
  - Bennington, Vermont, Forenede Stater, 05201
    - Green Mountain Oncology Group
  - Bennington, Vermont, Forenede Stater, 05201
    - Southwestern Vermont Regional Cancer Center
  - Berlin, Vermont, Forenede Stater, 05602
    - Mountainview Medical
  - Burlington, Vermont, Forenede Stater, 05401
    - Fletcher Allen Health Care - University Health Center Campus
  - Windsor, Vermont, Forenede Stater, 05089
    - Mount Ascutney Hospital
- Virginia
  - Danville, Virginia, Forenede Stater, 24541
    - Danville Regional Medical Center
  - Hampton, Virginia, Forenede Stater, 23666
    - Virginia Oncology Associates - Hampton
  - Norton, Virginia, Forenede Stater, 24273
    - Southwest Virginia Regional Cancer Center
  - Richmond, Virginia, Forenede Stater, 23298-0037
    - Massey Cancer Center at Virginia Commonwealth University
- Washington
  - Bellingham, Washington, Forenede Stater, 98225
    - St. Joseph Hospital Community Cancer Center
  - Bremerton, Washington, Forenede Stater, 98310
    - Olympic Hematology and Oncology
  - Mount Vernon, Washington, Forenede Stater, 98273
    - Skagit Valley Hospital Cancer Care Center
  - Seattle, Washington, Forenede Stater, 98104
    - Harborview Medical Center
  - Seattle, Washington, Forenede Stater, 98101
    - CCOP - Virginia Mason Research Center
  - Seattle, Washington, Forenede Stater, 98104
    - Fred Hutchinson Cancer Research Center
  - Seattle, Washington, Forenede Stater, 98104
    - Minor and James Medical, PLLC
  - Seattle, Washington, Forenede Stater, 98112
    - Group Health Central Hospital
  - Seattle, Washington, Forenede Stater, 98122
    - Polyclinic First Hill
  - Seattle, Washington, Forenede Stater, 98195-6043
    - University Cancer Center at University of Washington Medical Center
  - Seattle, Washington, Forenede Stater, 98114
    - Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
  - Sedro-Woolley, Washington, Forenede Stater, 98284
    - North Puget Oncology at United General Hospital
  - Spokane, Washington, Forenede Stater, 99202
    - Cancer Care Northwest - Spokane South
  - Spokane, Washington, Forenede Stater, 99204
    - Providence Cancer Center at Sacred Heart Medical Center
  - Spokane, Washington, Forenede Stater, 99207
    - Providence Cancer Center at Holy Family Hospital
  - Tacoma, Washington, Forenede Stater, 98431
    - Madigan Army Medical Center - Tacoma
  - Vancouver, Washington, Forenede Stater, 98668
    - Southwest Washington Medical Center Cancer Center
  - Wenatchee, Washington, Forenede Stater, 98801
    - Wenatchee Valley Clinic
  - Yakima, Washington, Forenede Stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yakima, Washington, Forenede Stater, 98902
    - Washington Hematology-Oncology Specialists
- West Virginia
  - Charleston, West Virginia, Forenede Stater, 25304
    - West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division
  - Morgantown, West Virginia, Forenede Stater, 26506
    - Mary Babb Randolph Cancer Center at West Virginia University Hospitals
- Wisconsin
  - Green Bay, Wisconsin, Forenede Stater, 54307-3508
    - St. Vincent Hospital Regional Cancer Center
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Green Bay Oncology, Limited at St. Mary's Hospital
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - St. Mary's Hospital Medical Center - Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54301-3526
    - Green Bay Oncology, Limited at St. Vincent Hospital
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
  - Madison, Wisconsin, Forenede Stater, 53792-6164
    - University of Wisconsin Comprehensive Cancer Center
  - Madison, Wisconsin, Forenede Stater, 53715
    - Dean Medical Center - Fish Hatchery
  - Manitowoc, Wisconsin, Forenede Stater, 54221-1450
    - Holy Family Memorial Medical Center Cancer Care Center
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Bay Area Cancer Care Center at Bay Area Medical Center
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Clinic - Marshfield Center
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Medical College of Wisconsin Cancer Center
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Green Bay Oncology, Limited - Oconto Falls
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235
    - Green Bay Oncology, Limited - Sturgeon Bay
- Wyoming
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center at Sheridan Memorial Hospital
Sydafrika
- - Pretoria, 0001, Sydafrika
    - Pretoria Academic Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

16 år og ældre (Barn, Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

Histologisk bevist tidligere ubehandlet klassisk Hodgkins lymfom
Følgende faser er berettigede:
- Lokalt omfattende: Stadie I-IIA/B med massiv mediastinal adenopati
- Avanceret: Trin III eller IV
Målbar eller evaluerbar sygdom
Alder på 16 og derover
ECOG Performance status 0-2
Sygdomsfri for tidligere invasive maligniteter i >5 år med undtagelse af kurativt behandlet basalcelle- eller pladecellekarcinom i huden eller carcinom in situ i livmoderhalsen
Hvide blodlegemer (WBC) mindst 4.000/mm³, (medmindre dokumenteret knoglemarvspåvirkning)
Blodpladetal mindst 100.000/mm³ (medmindre der er dokumenteret knoglemarvspåvirkning)
Bilirubin ikke større end 5,0 mg/dL
Kreatinin ikke større end 2,0 mg/dL
Bestemmelse af ejektionsfraktion anbefales, hvis over 50 år og/eller har en historie med hjertesygdom
Fertile patienter skal bruge effektiv prævention
Tidligere kortikosteroider tilladt
Forudgående operation tilladt

Ekskluderingskriterier:

Gravid eller ammende
Forudgående strålebehandling
Forudgående kemoterapi
Human immundefektvirus (HIV) positiv

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Arm A (ABVD) Arm A (ABVD): Patienterne får doxorubicin (25 mg/m²), bleomycin (10 u/m²), vinblastin (6 mg/m²) og dacarbazin (375 mg/m²) intravenøst (IV) på dag 1 og 15. Kurser gentages hver 28. dag. Patienterne genoptages efter 4 kure. Patienter, der er i fuldstændig remission, får 2 yderligere forløb. Patienter med delvis respons eller mindre evalueres efter 6 forløb, og hvis der er et løbende respons, kan patienter få 2 yderligere forløb på i alt 8. Hvis der ikke observeres noget vedvarende respons, fjernes patienterne fra undersøgelsen. Alle patienter med massiv mediastinumsygdom, uanset stadie, får strålebehandling 2-3 uger efter afslutning af kemoterapi.	Stråling: Strålebehandling Medicin: Doxorubicin givet IV Andre navne: Adriamycin Adriamycin PFS Adriamycin RDF hydroxydaunorubicin Rubex ADR hydroxydaunomycin Medicin: Bleomycin givet IV Andre navne: BLM Blenoxane Bleo Medicin: Vinblastin givet IV Andre navne: Velban Velsar vinblastinsulfat vincaleukoblastin VLB Alkaban AQ Medicin: Dacarbazin givet IV Andre navne: DIC DTIC DTIC-Dome imidazolcarboxamid dimethyltriazeno-imidazolcarboxamid
Aktiv komparator: Arm B (Stanford V) Arm B (Stanford V): Patienter modtager Stanford V-kemoterapi omfattende doxorubicin (25 mg/m²) og vinblastin (6 mg/m²) IV på dag 1 i uge 1, 3, 5, 7, 9 og 11; vincristin (1,4 mg/m²) og bleomycin (5 u/m²) IV på dag 1 i uge 2, 4, 6, 8, 10 og 12; mechlorethamin (6 mg/m²) IV på dag 1 i uge 1, 5 og 9 (hvis mechlorethamin ikke er tilgængelig, kan erstattes med cyclophosphamid [375 mg/m²] IV); etoposid (60 mg/m²) IV på dag 1 og 2 i uge 3, 7 og 11; og oral prednison (40 mg/m²) hver anden dag i uge 1-9 efterfulgt af en nedtrapning. Alle patienter med omfangsrig sygdom får strålebehandling 2-3 uger efter afslutning af kemoterapi.	Stråling: Strålebehandling Medicin: Cyclofosfamid givet IV Andre navne: Cytoxan CPM CTX Neosar Medicin: Doxorubicin givet IV Andre navne: Adriamycin Adriamycin PFS Adriamycin RDF hydroxydaunorubicin Rubex ADR hydroxydaunomycin Medicin: Bleomycin givet IV Andre navne: BLM Blenoxane Bleo Medicin: Vinblastin givet IV Andre navne: Velban Velsar vinblastinsulfat vincaleukoblastin VLB Alkaban AQ Medicin: Vincristine givet IV Andre navne: VCR Oncovin Vincasar PFS leurokristin LCR vincristinsulfat Medicin: Mechlorethamin givet IV Andre navne: nitrogensennep Mustargen Medicin: Etoposid givet IV Andre navne: EPEG VP-16 VP-16-213 VePesid epipodofyllotoksin Medicin: Prednison taget oralt Andre navne: Deltasone Orasone Panasol-S Medicorten Liquid-Pred

Deltagergruppe / Arm

Intervention / Behandling

Eksperimentel: Arm A (ABVD)

Arm A (ABVD): Patienterne får doxorubicin (25 mg/m²), bleomycin (10 u/m²), vinblastin (6 mg/m²) og dacarbazin (375 mg/m²) intravenøst (IV) på dag 1 og 15. Kurser gentages hver 28. dag. Patienterne genoptages efter 4 kure. Patienter, der er i fuldstændig remission, får 2 yderligere forløb. Patienter med delvis respons eller mindre evalueres efter 6 forløb, og hvis der er et løbende respons, kan patienter få 2 yderligere forløb på i alt 8. Hvis der ikke observeres noget vedvarende respons, fjernes patienterne fra undersøgelsen. Alle patienter med massiv mediastinumsygdom, uanset stadie, får strålebehandling 2-3 uger efter afslutning af kemoterapi.

Stråling: Strålebehandling

Medicin: Doxorubicin

givet IV

Andre navne:

Adriamycin
Adriamycin PFS
Adriamycin RDF
hydroxydaunorubicin
Rubex
ADR
hydroxydaunomycin

Medicin: Bleomycin

givet IV

Andre navne:

BLM
Blenoxane
Bleo

Medicin: Vinblastin

givet IV

Andre navne:

Velban
Velsar
vinblastinsulfat
vincaleukoblastin
VLB
Alkaban AQ

Medicin: Dacarbazin

givet IV

Andre navne:

DIC
DTIC
DTIC-Dome
imidazolcarboxamid
dimethyltriazeno-imidazolcarboxamid

Aktiv komparator: Arm B (Stanford V)

Arm B (Stanford V): Patienter modtager Stanford V-kemoterapi omfattende doxorubicin (25 mg/m²) og vinblastin (6 mg/m²) IV på dag 1 i uge 1, 3, 5, 7, 9 og 11; vincristin (1,4 mg/m²) og bleomycin (5 u/m²) IV på dag 1 i uge 2, 4, 6, 8, 10 og 12; mechlorethamin (6 mg/m²) IV på dag 1 i uge 1, 5 og 9 (hvis mechlorethamin ikke er tilgængelig, kan erstattes med cyclophosphamid [375 mg/m²] IV); etoposid (60 mg/m²) IV på dag 1 og 2 i uge 3, 7 og 11; og oral prednison (40 mg/m²) hver anden dag i uge 1-9 efterfulgt af en nedtrapning. Alle patienter med omfangsrig sygdom får strålebehandling 2-3 uger efter afslutning af kemoterapi.

Stråling: Strålebehandling

Medicin: Cyclofosfamid

givet IV

Andre navne:

Cytoxan
CPM
CTX
Neosar

Medicin: Doxorubicin

givet IV

Andre navne:

Adriamycin
Adriamycin PFS
Adriamycin RDF
hydroxydaunorubicin
Rubex
ADR
hydroxydaunomycin

Medicin: Bleomycin

givet IV

Andre navne:

BLM
Blenoxane
Bleo

Medicin: Vinblastin

givet IV

Andre navne:

Velban
Velsar
vinblastinsulfat
vincaleukoblastin
VLB
Alkaban AQ

Medicin: Vincristine

givet IV

Andre navne:

VCR
Oncovin
Vincasar PFS
leurokristin
LCR
vincristinsulfat

Medicin: Mechlorethamin

givet IV

Andre navne:

nitrogensennep
Mustargen

Medicin: Etoposid

givet IV

Andre navne:

EPEG
VP-16
VP-16-213
VePesid
epipodofyllotoksin

Medicin: Prednison

taget oralt

Andre navne:

Deltasone
Orasone
Panasol-S
Medicorten
Liquid-Pred

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Fejlfri overlevelse ved 5 år Tidsramme: Vurderet hver 2. måned, hvis patienten er < 1 år fra studiestart, hver 3. måned i det andet år, hver 4. måned i det tredje år, hver 6. måned i år 4 og 5	Fejlfri overlevelse er defineret som tiden fra randomisering til det tidligere af progression/tilbagefald eller død. Den 5-årige fejlfri overlevelse er sandsynligheden for, at en patient er fejlfri og overlever 5 år. Progression defineres som en stigning i størrelsen på 25 % af summen af produkterne fra førbehandlingsmålingerne eller fremkomsten af nye læsioner. Betydelig forstørrelse af leveren eller milten er tegn på progression. En signifikant stigning i størrelse er defineret som > 2,0 cm i afstand mellem costal margin og den inferior margin af begge organer. Tilbagefald er defineret som gensynet med kliniske tegn på Hodgkins sygdom hos en patient, der har haft et fuldstændigt respons. Tilbagefald for partielle respondere er defineret som progressiv sygdom i forhold til sygdomsstatus under den partielle remission.	Vurderet hver 2. måned, hvis patienten er < 1 år fra studiestart, hver 3. måned i det andet år, hver 4. måned i det tredje år, hver 6. måned i år 4 og 5

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
5-års samlet overlevelse Tidsramme: Vurderet hver 2. måned, hvis patienten er < 1 år fra studiestart, hver 3. måned i det andet år, hver 4. måned i det tredje år, hver 6. måned i år 4 og 5 og årligt i 5 år	Samlet overlevelse er defineret som tiden fra randomisering til død eller sidst kendt i live. 5-års overlevelsesraten er sandsynligheden for, at en patient overlever 5 år.	Vurderet hver 2. måned, hvis patienten er < 1 år fra studiestart, hver 3. måned i det andet år, hver 4. måned i det tredje år, hver 6. måned i år 4 og 5 og årligt i 5 år
Forekomst af anden kræft Tidsramme: Vurderet hver 2. måned, hvis patienten er < 1 år fra studiestart, hver 3. måned i det andet år, hver 4. måned i det tredje år, hver 6. måned i år 4 og 5 og årligt i 5 år	Antal patienter, der udviklede anden primær cancer	Vurderet hver 2. måned, hvis patienten er < 1 år fra studiestart, hver 3. måned i det andet år, hver 4. måned i det tredje år, hver 6. måned i år 4 og 5 og årligt i 5 år

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Eastern Cooperative Oncology Group

Samarbejdspartnere

National Cancer Institute (NCI)

Efterforskere

Studiestol: Sandra J. Horning, MD, Stanford University

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

17. juni 1999

Primær færdiggørelse (Faktiske)

1. september 2011

Studieafslutning (Faktiske)

1. maj 2016

Datoer for studieregistrering

Først indsendt

1. november 1999

Først indsendt, der opfyldte QC-kriterier

26. januar 2003

Først opslået (Anslået)

27. januar 2003

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

29. juni 2023

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

14. juni 2023

Sidst verificeret

1. juni 2023

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

CDR0000066386
U10CA021115 (U.S. NIH-bevilling/kontrakt)
E2496 (Anden identifikator: Eastern Cooperative Oncology Group (ECOG))

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Strålebehandling

Yonsei University

Rekruttering

Karbonion-stråleterapi hos skrøbelige patienter med bugspytkirtelkræft

Pancreas neoplasma

Sydkorea
Center Eugene Marquis

Rekruttering

Optisk overfladevejledning til ekstern strålebehandling af hoved- og nakkekræft (SUGAR)

Otorhinolaryngeal kræft

Frankrig
Institut für Klinische Krebsforschung IKF GmbH...
AstraZeneca; Thoraxklinik-Heidelberg gGmbH

Afsluttet

Thoracic Radiotherapy Plus Durvalumab hos ældre og/eller svage NSCLC Stadium III-patienter, der ikke er egnede til kemoterapi (TRADE-hypo)

NSCLC, trin III

Tyskland
European Institute of Oncology
Associazione Italiana per la Ricerca sul Cancro

Rekruttering

Carbon Ions Boost efterfulgt af Pelvic Photon Radiotherapy for højrisiko prostatakræft

Adenocarcinom i prostata

Italien
Yonsei University

Rekruttering

En fase II enarms klinisk undersøgelse til vurdering af effektiviteten og sikkerheden af karbonion-stråleterapi med atezolizumab og bevacizumab kombinationsbehandling hos patienter med fremskreden hepatocellulært karcinom

Karcinom | Neoplasmer i leveren | Hepatocellulært karcinom | Hepatocellulær

Sydkorea
Yonsei University

Ikke rekrutterer endnu

Prospektiv fase I/II-studie, der evaluerer sikkerhed og effekt af præoperativ karbonion-stråleterapi hos patienter med bløddele sarkom: SARCOMA-01-forsøget udført af Severance sARCOma Multidisciplinært Team (SARCOMA-01)

Blødt vævssarkom

Sydkorea
Cancer Trials Ireland
University College Dublin; Technological University Dublin

Rekruttering

'KILDE - LUNGE' Stereotaktisk Ablativ Stråleterapi af UltRaCentrale Lungetumorer (KILDE Lunge) (SOURCE Lung)

NSCLC/Oligometastatisk kræft (enkelt lungelæsion)

Irland
Memorial Sloan Kettering Cancer Center

Aktiv, ikke rekrutterende

En undersøgelse af strålebehandling før CAR T-celleterapi til mennesker med B-celle lymfom

Non-Hodgkin lymfom | Non-Hodgkins lymfom, tilbagefald | Non-Hodgkins lymfom refraktær

Forenede Stater
RefleXion Medical

Afsluttet

Ydeevne og sikkerhed ved biologistyret strålebehandling ved brug af RefleXion Medical Radiotherapy System (BIOGUIDE-X) (BIOGUIDE-X)

Kræft | Tumor, fast | Kræft, lunge | Metastase til knogle | Metastase til lunge | Kræft, Bone

Forenede Stater
Sunnybrook Health Sciences Centre

Aktiv, ikke rekrutterende

UNITY-BASED MR-Linac Adaptive Simultaneous Integrated Hypofractioned Boost Trial for High Grad Gliom hos ældre (UNITED2)

Glioblastom, IDH-mutant | Glioblastoma Multiforme, voksen

Canada

Kombinationskemoterapi med eller uden strålebehandling til behandling af patienter med Hodgkins lymfom

Et randomiseret fase III-forsøg med ABVD versus Stanford V (+/-) strålebehandling ved lokalt omfattende og avanceret Hodgkins sygdom

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Publikationer og nyttige links

Generelle publikationer

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Faktiske)

Studieafslutning (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Anslået)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Kliniske forsøg med Strålebehandling

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Mauritania

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer