- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT00231712
Immuno 1: Immune Reconstitution Following Conventional or High-Dose Chemotherapy With Stem Cell Transplant
Prospective Analysis of the Patterns of Immune Reconstitution Following Conventional or High-Dose Chemotherapy With Autologous/Allogeneic Stem Cell Transplant
The purpose of this study is to conduct an analysis of the influences of
- conventional chemotherapy
- high-dose chemotherapy followed by autologous stem cell transplant
- high-dose chemotherapy followed by allogeneic stem cell transplant on the recovery of the immune system.
Detailed analysis will help to better understand the pathways of recovery of the immune system following chemotherapy as well as the pathways of recovery of the immune system following autologous or allogeneic stem cell transplantation.
Studieoversigt
Status
Betingelser
Detaljeret beskrivelse
Detailed analysis will be performed at preselected time points following therapy by
- standard flow cytometry in combination with intracellular cytokine/antigen staining
- spectratype analysis
- TREC assays
Undersøgelsestype
Tilmelding
Kontakter og lokationer
Studiekontakt
- Navn: Paul G Schlegel, MD
Undersøgelse Kontakt Backup
- Navn: Beate Winkler, MD
Studiesteder
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Wuerzburg, Tyskland, D97080
- Rekruttering
- University Children's Hospital Pedaitric Oncology
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Kontakt:
- Beate Winkler, MD
- Telefonnummer: 49 - 931 - 201 - 27831
- E-mail: winkler_b@klinik.uni.wuerzburg.de
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Ledende efterforsker:
- Beate Winkler, MD
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria:
- Acute leukemia treated according to current ALL-BFM 2002 protocol
- Solid tumor treated according to current GPOH-protocol
- Medulloblastoma treated according to HIT-2000 protocol
- High-dose chemotherapy followed by autologous stem cell transplantation
- High-dose chemotherapy followed by allogeneic stem cell transplantation
- Written consent according to our institutional guidelines
Exclusion Criteria:
- No written consent
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Samarbejdspartnere og efterforskere
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Paul G Schlegel, MD, University Children's Hospital Pediatric Oncology Wuerzburg / Germany
- Studieleder: Matthias Eyrich, MD, Pediatric Stem Cell Transplant Program
Publikationer og nyttige links
Generelle publikationer
- Eyrich M, Wollny G, Tzaribaschev N, Dietz K, Brugger D, Bader P, Lang P, Schilbach K, Winkler B, Niethammer D, Schlegel PG. Onset of thymic recovery and plateau of thymic output are differentially regulated after stem cell transplantation in children. Biol Blood Marrow Transplant. 2005 Mar;11(3):194-205. doi: 10.1016/j.bbmt.2004.12.001.
- Eyrich M, Leiler C, Lang P, Schilbach K, Schumm M, Bader P, Greil J, Klingebiel T, Handgretinger R, Niethammer D, Schlegel PG. A prospective comparison of immune reconstitution in pediatric recipients of positively selected CD34+ peripheral blood stem cells from unrelated donors vs recipients of unmanipulated bone marrow from related donors. Bone Marrow Transplant. 2003 Aug;32(4):379-90. doi: 10.1038/sj.bmt.1704158.
- Eyrich M, Croner T, Leiler C, Lang P, Bader P, Klingebiel T, Niethammer D, Schlegel PG. Distinct contributions of CD4(+) and CD8(+) naive and memory T-cell subsets to overall T-cell-receptor repertoire complexity following transplantation of T-cell-depleted CD34-selected hematopoietic progenitor cells from unrelated donors. Blood. 2002 Sep 1;100(5):1915-8. doi: 10.1182/blood-2001-11-0005.
Datoer for undersøgelser
Studer store datoer
Studiestart
Studieafslutning
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 133/04
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