A Study of MK2578 in Patients With Chronic Kidney Disease Who Are Not on Dialysis (2578-002)
30. oktober 2015 opdateret af: Merck Sharp & Dohme LLC
A Phase IIb Randomized, Active Comparator-Controlled, Open-Label Clinical Trial to Study the Efficacy and Safety of MK2578 for the Treatment of Anemia in ESA (Erythropoiesis-Stimulating Agent)-Naive Patients With Chronic Kidney Disease Who Are Not on Dialysis.
This study will define an effective starting dose for subcutaneous administration of MK2578 to correct anemia in erythropoiesis-stimulating agent (ESA)-naive patients with chronic kidney disease (CKD) who are not on dialysis while evaluating its safety.
Studieoversigt
Status
Afsluttet
Betingelser
Intervention / Behandling
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
7
Fase
- Fase 2
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år til 75 år (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Beskrivelse
Inclusion Criteria:
- Patient is male or is a female who either cannot have children or who agrees to use appropriate contraceptive measures
- Patient has chronic kidney disease
Exclusion Criteria:
- Patient is morbidly obese
- Patient has used another erythropoiesis (red blood cell formation) stimulating agent within 12 weeks of screening
- Patient will require dialysis during the study or is planning to have a kidney transplant within the next 6 months
- Patient has had a blood transfusion within 12 weeks of screening
- Patient has had major surgery within the past 12 weeks or plans to have surgery
- Patient has Human Immunodeficiency Virus (HIV)
- Patient has a history of diseases other than CKD known to cause anemia
- Patient has severe congestive heart failure
- Patient has history of malignant cancer, except certain skin or cervical cancers
- Patient has a history of grand mal seizures within the last 6 months
- Patient is pregnant or breastfeeding
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: MK2578 1.0 mcg/kg
MK2578
|
MK2578 1.0 mcg/kg/month
MK2578 2.0 mcg/kg/month
MK2578 3.6 mcg/kg/month
|
|
Eksperimentel: MK2578 2.0 mcg/kg
MK2578
|
MK2578 1.0 mcg/kg/month
MK2578 2.0 mcg/kg/month
MK2578 3.6 mcg/kg/month
|
|
Eksperimentel: MK2578 3.6 mcg/kg
MK2578
|
MK2578 1.0 mcg/kg/month
MK2578 2.0 mcg/kg/month
MK2578 3.6 mcg/kg/month
|
|
Aktiv komparator: Darbepoetin alfa
darbepoetin alfa
|
darbepoetin alfa
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Change From Baseline in Hemoglobin Level at Week 4
Tidsramme: 4 weeks
|
4 weeks
|
|
Number of Participants With Composite Events of Death, Myocardial Infarction and Cerebrovascular Accident, Serious Events of Unstable Angina, Transient Ischemic Attack, Arrythmia and Congestive Heart Failure, Peripheral Thrombo-embolic Events
Tidsramme: 16 Weeks
|
16 Weeks
|
|
Number of Participants With Composite Events of Transfusion-related Adverse Experiences
Tidsramme: 16 Weeks
|
16 Weeks
|
|
Number of of Participants With Composite Events of Injection Site Reactions
Tidsramme: 16 Weeks
|
16 Weeks
|
|
Number of Participants With Hypertension, Seizure, and Pure Red Cell Aplasia
Tidsramme: 16 Weeks
|
16 Weeks
|
|
Number of Participants With Confirmed, Treatment Emergent Antibodies to MK2578
Tidsramme: 16 Weeks
|
16 Weeks
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Hemoglobin Concentration After Treatment With MK2578
Tidsramme: Weeks 1-10 and Week 12
|
Weeks 1-10 and Week 12
|
|
|
Change From Baseline in Hemoglobin Level
Tidsramme: Weeks 1-3, 5-10, and Week 12
|
Weeks 1-3, 5-10, and Week 12
|
|
|
Number of Participants Who Were Responders
Tidsramme: Each week up to 12 weeks
|
Responder was defined as a participant achieving (pre-transfusion) an increase from baseline hemoglobin of greater than or equal to 1 g/dL and a hemoglobin concentration of greater than or equal to 11 g/dL.
|
Each week up to 12 weeks
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. november 2009
Primær færdiggørelse (Faktiske)
1. april 2010
Studieafslutning (Faktiske)
1. maj 2010
Datoer for studieregistrering
Først indsendt
27. august 2009
Først indsendt, der opfyldte QC-kriterier
28. august 2009
Først opslået (Skøn)
31. august 2009
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
1. november 2015
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
30. oktober 2015
Sidst verificeret
1. oktober 2015
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 2578-002
- 2009_653
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-
Connecticut Children's Medical CenterChildren's Hospital of Philadelphia; National Heart, Lung, and Blood Institute... og andre samarbejdspartnereIkke rekrutterer endnuSeglcellesygdom | Seglcellesygdom (SCD) | Seglcelleanæmi hos børn | Seglcelle | Sickle Cell Anemia (HBSS)Forenede Stater
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Kliniske forsøg med MK2578
-
Merck Sharp & Dohme LLCAfsluttet