Follicle Stimulating Hormone (FSH) Receptor Polymorphisms in In-Vitro Fertilization Cycles.
The Use of FSH Receptor Polymorphisms To Improve Pregnancy Rates In In-Vitro Fertilization
Studieoversigt
Status
Betingelser
Detaljeret beskrivelse
All IVF patients who meet inclusion criteria and not exclusion criteria will be asked to participate in this study. Upon consent, a blood sample will be obtained in 2 EDTA containing lavender topped tubes before, during or within 3 months after their IVF cycle. Genomic DNA will be extracted and saved for genotyping.
The Investigators will collect data on each individual's age, ethnic background, and estradiol levels on the day of hCG administration, total gonadotropin amount, clinical pregnancy rates, basal FSH levels, and occurrence of OHSS. The Investigators will then analyze all samples from all patients for their FSH receptor genotypes.
Patients will be compensated $75 via a check within 6-8 weeks of their blood drawn.
Undersøgelsestype
Tilmelding (Faktiske)
Kontakter og lokationer
Studiesteder
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New Jersey
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Hasbrouck Heights, New Jersey, Forenede Stater, 07604
- University Reproductive Associates
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Hoboken, New Jersey, Forenede Stater, 07030
- University Reproductive Associates
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-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Beskrivelse
Inclusion Criteria:
- 100 women less than 35 years old at time of signing the Informed Consent Form.
- Day 3 FSH level less than or equal to 10 mIU/ml with an estradiol < 70 pg/ml
- Day 3 antral follicle count of greater than 10 follicles total.
- Couples who have male factor infertility, tubal factor infertility, and unexplained infertility.
Exclusion Criteria patients who have:
- Endometriosis
- Polycystic ovarian syndrome
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
The primary outcome measure is to evaluate the frequency of FSH receptor polymorphisms in our population.
Tidsramme: 3 years
|
The investigators are looking to quantify how often certain FSH receptor Polymorphisms occur in the population and cetain racial groups.
We will be looking at patient's race along with the laboratory results.
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3 years
|
Sekundære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
The secondary outcome is to further clarify the variation in response to FSH due to FSH receptor polymorphisms using the protocols largely used in the United States, including our center.
Tidsramme: 3 years
|
3 years
|
Samarbejdspartnere og efterforskere
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Aimee Seungdamrong, MD, University Reproductive Associates
Datoer for undersøgelser
Studer store datoer
Studiestart
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 0120090163
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