The Effect of Multiple Medications on the Incidence of Organic Dyspepsia

the rate of patients diagnosed with organic upper gastrointestinal (GI) diseases.

All included patients underwent upper GI endoscopy and abdominal ultrasound and H. Pylori test. Barrett's esophagus, esophageal candidiasis, esophageal cancer, gastric ulcer, gastric erosion, gastric cancer, duodenal ulcer, duodenal erosion, cholecystitis, pancreatitis and biliary stones were classified as organic upper GI diseases.

Short Form of Nepean Dyspepsia Index (SF-NDI)

SF-NDI består af 10 spørgsmål vedrørende virkningerne af dyspepsisymptomer ("maveproblemer") på forskellige aspekter af livet (spændinger, forstyrrelse af daglige aktiviteter, spisning/drikning, viden/kontrol og arbejde/studie). Hvert svar kan være fra 1 (slet ikke påvirket) til 5 (ekstremt påvirket) eller 0 (ikke relevant), for en samlet summeret score ud af 50.

Functional dyspepsia

Functional dyspepsia was defined by Rome IV criteria, which was based on symptom and duration rather than scores. Patients diagnosed as Rome IV criteria met one or more of following criteria: postprandial fullness, early satiation, epigastric pain, and epigastric burning that are unexplained after a routine clinical evaluation, Criteria fulfilled for the last 3 months with symptom onset at least 6 months before diagnosis. the above symptoms and durations were included in the questionaire. Physiological parameter was not required for Rome IV criteria.

Number of participants with different subtypes of functional dyspepsia

Functional dyspepsia was based on Rome IV criteria, which was based on symptom and duration rather than scores. Functional dyspepsia was classified into three subgroups：(1) Postprandial Distress Syndrome, Must include one or both of the following at least 3 days per week: 1. Bothersome postprandial fullness (ie, severe enough to impact on usual activities) 2. Bothersome early satiation (ie, severe enough to prevent finishing a regular-size meal) (2) Bothersome epigastric pain, Must include at least 1 of the following symptoms at least 1 day a week: 1. Bothersome epigastric pain (ie, severe enough to impact on usual activities) AND/OR 2. Bothersome epigastric burning (ie, severe enough to impact on usual activities). (3) mixed syndrome, defined when postprandial distress syndrome and epigastric pain syndrome presented simultaneously

Hospital anxiety scale

Anxiety of patients are assessed by using Hospital Anxiety Scale.It contains 7 items, which assess symptoms experienced during the past week on a 0-3 scale. A subscore of > 8 for anxiety would indicate a clinical case.

Hospital depression scale

Depression of patients are assessed by using Hospital Depression Scale. It contains 7 items, which assess symptoms experienced during the past week on a 0-3 scale. A score of > 8 for depression would indicate a clinical case.

Quality of Life scores

Quality of Life scores assessed by Patient-reported outcomes measurement information system (PROMIS) Global-10 questionnaire.PROMIS Global-10 is a newly validated 10-question survey used to assess health care-related quality of life measures for the general population. It's a 10-item patient-reported questionnaire in which the response options are presented as 5-point (as well as a single 11-point) rating scales. These scores are then standardized to the general population, using the "T-Score". The average "T-Score" for the United States population is 50 points, with a standard deviation of 10 points. Higher scores indicate a healthier patient and a better quality of life.

Severity of functional dyspepsia judged by patients

Patients rated the severity of functional dyspepsia as mild, moderate, and severe by themselves.

Number of participants with other functional gastrointestinal diseases

Other functional gastrointestinal diseases#such as irritable bowel syndrome(IBS) or functional heartburn#etc.