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Intervention on Mathematical Problem-Solving Skills

20. august 2026 opdateret af: Vinod Menon, Stanford University

Interventions in Math Learning Disabilities: Cognitive and Neural Correlates

The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing and remediating weaknesses in arithmetic skills in children, including those with mathematical learning disabilities.

Studieoversigt

Status

Ikke rekrutterer endnu

Betingelser

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

160

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • California
      • Palo Alto, California, Forenede Stater, 94304
        • Stanford University
        • Ledende efterforsker:
          • Vinod Menon, Ph.D.
        • Kontakt:

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Barn

Tager imod sunde frivillige

Ja

Beskrivelse

Inclusion Criteria:

  1. Elementary school-aged children starting from first grade (6-12 years old)
  2. Intelligence Quotient: Participants with a Full Scale Intelligence Quotient is greater than 70 on the Wechsler Abbreviated Scale of Intelligence Quotient
  3. Identification of Mathematical Learning Disabilities: Scores below the 20th percentile on two or more Wechsler Individual Achievement Test, Fourth Edition math subtests
  4. Identification of typically developing children: Scores at or above the 50th percentile on two or more Wechsler Individual Achievement Test, Fourth Edition math subtests
  5. Normal or corrected-to-normal vision and no hearing impairments
  6. Inclusion in MRI scan session: Right-handed

Exclusion Criteria:

  1. History of neurological or psychiatric disorder (i.e., schizophrenia, psychosis, depression, or attention deficit hyperactivity disorder)
  2. History of trauma involving head injury
  3. Consistent psychiatric medications
  4. Exclusion from magnetic resonance imaging scan session: No major contraindication for magnetic resonance imaging (braces, metal implants, pacemakers, vascular stents, metallic ear tubes, consistent exposure to metal, or claustrophobia)

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: Arithmetic strategy training
Participants complete 6 weeks of activities, 1-hour hybrid sessions daily for 3 days per week (in total 18 sessions), that progressively develop the efficient use of arithmetic problem-solving strategies. Before and after training, participants complete arithmetic problem-solving tasks during neuroimaging sessions.
Adfærdsmæssigt: Arithmetic strategy training
Arithmetic strategy training includes activities that progressively develop the efficient use of arithmetic problem-solving strategies.
Aktiv komparator: Speeded practice training
Participants complete 6 weeks of activities, 1-hour hybrid sessions daily for 3 days per week (in total 18 sessions), that focus solely on enhancing arithmetic fluency. Before and after training, participants complete arithmetic problem-solving tasks during neuroimaging sessions.
Adfærdsmæssigt: Speeded practice training
Speeded practice training includes activities that focus solely on enhancing arithmetic fluency.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Change from baseline in arithmetic task performance (reaction time)
Tidsramme: Baseline and post-intervention (after 6 weeks)
Performance will be measured by children's reaction time (milliseconds) on arithmetic task
Baseline and post-intervention (after 6 weeks)
Change from baseline in arithmetic task performance (accuracy)
Tidsramme: Baseline and post-intervention (after 6 weeks)
Performance will be measured by children's accuracy (% trials correct) on arithmetic task
Baseline and post-intervention (after 6 weeks)
Change from baseline in latent cognitive measures of arithmetic task performance (drift rate)
Tidsramme: Baseline and post-intervention (after 6 weeks)
Latent cognitive processing will be measured by drift rate from children's arithmetic task performance
Baseline and post-intervention (after 6 weeks)
Change from baseline in latent cognitive measures of arithmetic performance (post-error adjustment)
Tidsramme: Baseline and post-intervention (after 6 weeks)
Latent cognitive processing will be measured by post-error adjustment from children's arithmetic task performance
Baseline and post-intervention (after 6 weeks)
Change from baseline in brain activation during arithmetic task performance
Tidsramme: Baseline and post-intervention (after 6 weeks)
Neural activity will be measured during a functional magnetic resonance imaging arithmetic task. Data will consist of beta values from individual-subject contrast maps for the Small vs. Large contrast in the whole-brain general linear modeling functional magnetic resonance imaging analysis.
Baseline and post-intervention (after 6 weeks)
Change from baseline in brain representation during arithmetic task performance
Tidsramme: Baseline and post-intervention (after 6 weeks)
Neural activity will be measured during the functional magnetic resonance imaging arithmetic task. Data will consist of spatial correlations of voxel-wise brain activation between Trained vs. Rest and Untrained vs. Rest contrasts for individual subjects.
Baseline and post-intervention (after 6 weeks)
Change from baseline in brain connectivity during arithmetic task performance
Tidsramme: Baseline and post-intervention (after 6 weeks)

Neural activity will be measured during the functional magnetic resonance imaging arithmetic task. Data will consist of generalized psychophysiological interaction beta values from individual subject contrast maps for Small vs.

Large contrast.
Baseline and post-intervention (after 6 weeks)

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Change from baseline in untrained arithmetic task performance (reaction time)
Tidsramme: Baseline and post-intervention (after 6 weeks)
Performance will be measured by children's reaction time (milliseconds) on untrained arithmetic task
Baseline and post-intervention (after 6 weeks)
Change from baseline in untrained arithmetic task performance (accuracy)
Tidsramme: Baseline and post-intervention (after 6 weeks)
Performance will be measured by children's accuracy (% trials correct) on untrained arithmetic task
Baseline and post-intervention (after 6 weeks)

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Stanford University

Samarbejdspartnere

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Efterforskere

  • Ledende efterforsker: Vinod Menon, Ph.D., Stanford University

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Anslået)

1. september 2026

Primær færdiggørelse (Anslået)

1. september 2031

Studieafslutning (Anslået)

1. september 2031

Datoer for studieregistrering

Først indsendt

18. august 2026

Først indsendt, der opfyldte QC-kriterier

18. august 2026

Først opslået (Faktiske)

21. august 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

24. august 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

20. august 2026

Sidst verificeret

1. august 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 87897
  • R01HD059205 (U.S. NIH-bevilling/kontrakt)

Plan for individuelle deltagerdata (IPD)

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