Intervention on Mathematical Problem-Solving Skills
20. august 2026 oppdatert av: Vinod Menon, Stanford University
Interventions in Math Learning Disabilities: Cognitive and Neural Correlates
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing and remediating weaknesses in arithmetic skills in children, including those with mathematical learning disabilities.
Studieoversikt
Status
Har ikke rekruttert ennå
Intervensjon / Behandling
Studietype
Intervensjonell
Registrering (Antatt)
160
Fase
- Ikke aktuelt
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
-
-
California
-
Palo Alto, California, Forente stater, 94304
- Stanford University
-
Hovedetterforsker:
- Vinod Menon, Ph.D.
-
Ta kontakt med:
- Zehra E Unal, Ph.D.
- Telefonnummer: 7376150834
- E-post: zehraeu@stanford.edu
-
-
Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
- Barn
Tar imot friske frivillige
Ja
Beskrivelse
Inclusion Criteria:
- Elementary school-aged children starting from first grade (6-12 years old)
- Intelligence Quotient: Participants with a Full Scale Intelligence Quotient is greater than 70 on the Wechsler Abbreviated Scale of Intelligence Quotient
- Identification of Mathematical Learning Disabilities: Scores below the 20th percentile on two or more Wechsler Individual Achievement Test, Fourth Edition math subtests
- Identification of typically developing children: Scores at or above the 50th percentile on two or more Wechsler Individual Achievement Test, Fourth Edition math subtests
- Normal or corrected-to-normal vision and no hearing impairments
- Inclusion in MRI scan session: Right-handed
Exclusion Criteria:
- History of neurological or psychiatric disorder (i.e., schizophrenia, psychosis, depression, or attention deficit hyperactivity disorder)
- History of trauma involving head injury
- Consistent psychiatric medications
- Exclusion from magnetic resonance imaging scan session: No major contraindication for magnetic resonance imaging (braces, metal implants, pacemakers, vascular stents, metallic ear tubes, consistent exposure to metal, or claustrophobia)
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Eksperimentell: Arithmetic strategy training
Participants complete 6 weeks of activities, 1-hour hybrid sessions daily for 3 days per week (in total 18 sessions), that progressively develop the efficient use of arithmetic problem-solving strategies.
Before and after training, participants complete arithmetic problem-solving tasks during neuroimaging sessions.
|
Arithmetic strategy training includes activities that progressively develop the efficient use of arithmetic problem-solving strategies.
|
|
Aktiv komparator: Speeded practice training
Participants complete 6 weeks of activities, 1-hour hybrid sessions daily for 3 days per week (in total 18 sessions), that focus solely on enhancing arithmetic fluency.
Before and after training, participants complete arithmetic problem-solving tasks during neuroimaging sessions.
|
Speeded practice training includes activities that focus solely on enhancing arithmetic fluency.
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Change from baseline in arithmetic task performance (reaction time)
Tidsramme: Baseline and post-intervention (after 6 weeks)
|
Performance will be measured by children's reaction time (milliseconds) on arithmetic task
|
Baseline and post-intervention (after 6 weeks)
|
|
Change from baseline in arithmetic task performance (accuracy)
Tidsramme: Baseline and post-intervention (after 6 weeks)
|
Performance will be measured by children's accuracy (% trials correct) on arithmetic task
|
Baseline and post-intervention (after 6 weeks)
|
|
Change from baseline in latent cognitive measures of arithmetic task performance (drift rate)
Tidsramme: Baseline and post-intervention (after 6 weeks)
|
Latent cognitive processing will be measured by drift rate from children's arithmetic task performance
|
Baseline and post-intervention (after 6 weeks)
|
|
Change from baseline in latent cognitive measures of arithmetic performance (post-error adjustment)
Tidsramme: Baseline and post-intervention (after 6 weeks)
|
Latent cognitive processing will be measured by post-error adjustment from children's arithmetic task performance
|
Baseline and post-intervention (after 6 weeks)
|
|
Change from baseline in brain activation during arithmetic task performance
Tidsramme: Baseline and post-intervention (after 6 weeks)
|
Neural activity will be measured during a functional magnetic resonance imaging arithmetic task.
Data will consist of beta values from individual-subject contrast maps for the Small vs. Large contrast in the whole-brain general linear modeling functional magnetic resonance imaging analysis.
|
Baseline and post-intervention (after 6 weeks)
|
|
Change from baseline in brain representation during arithmetic task performance
Tidsramme: Baseline and post-intervention (after 6 weeks)
|
Neural activity will be measured during the functional magnetic resonance imaging arithmetic task.
Data will consist of spatial correlations of voxel-wise brain activation between Trained vs. Rest and Untrained vs. Rest contrasts for individual subjects.
|
Baseline and post-intervention (after 6 weeks)
|
|
Change from baseline in brain connectivity during arithmetic task performance
Tidsramme: Baseline and post-intervention (after 6 weeks)
|
Neural activity will be measured during the functional magnetic resonance imaging arithmetic task. Data will consist of generalized psychophysiological interaction beta values from individual subject contrast maps for Small vs. Large contrast. |
Baseline and post-intervention (after 6 weeks)
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Change from baseline in untrained arithmetic task performance (reaction time)
Tidsramme: Baseline and post-intervention (after 6 weeks)
|
Performance will be measured by children's reaction time (milliseconds) on untrained arithmetic task
|
Baseline and post-intervention (after 6 weeks)
|
|
Change from baseline in untrained arithmetic task performance (accuracy)
Tidsramme: Baseline and post-intervention (after 6 weeks)
|
Performance will be measured by children's accuracy (% trials correct) on untrained arithmetic task
|
Baseline and post-intervention (after 6 weeks)
|
Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Samarbeidspartnere
Etterforskere
- Hovedetterforsker: Vinod Menon, Ph.D., Stanford University
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart (Antatt)
1. september 2026
Primær fullføring (Antatt)
1. september 2031
Studiet fullført (Antatt)
1. september 2031
Datoer for studieregistrering
Først innsendt
18. august 2026
Først innsendt som oppfylte QC-kriteriene
18. august 2026
Først lagt ut (Faktiske)
21. august 2026
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
24. august 2026
Siste oppdatering sendt inn som oppfylte QC-kriteriene
20. august 2026
Sist bekreftet
1. august 2026
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- 87897
- R01HD059205 (U.S. NIH-stipend/kontrakt)
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
NEI
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
Nei
Studerer et amerikansk FDA-regulert enhetsprodukt
Nei
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .