Peroxide Versus Non-Peroxide In-Office Tooth Bleaching: A Randomized Clinical Trial (BECTS)
8. september 2026 opdateret af: Esraa Eid Qurany, Minia University
Bleaching Efficacy, Color Durability, and Tooth Sensitivity After In-Office Bleaching With Peroxide Versus Non-Peroxide Systems: A Randomized Clinical Trial
This randomized clinical trial aims to compare the effectiveness of peroxide and non-peroxide in-office tooth bleaching systems.
The study will evaluate tooth whitening efficacy, color durability over time, and tooth sensitivity after treatment.
Participants will receive one of the two bleaching treatments and will be followed for six months to assess the clinical outcomes and compare the performance of both systems.
Studieoversigt
Status
Rekruttering
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
This randomized controlled clinical trial is designed to compare the clinical performance of peroxide-based and non-peroxide in-office tooth bleaching systems.
Eligible participants will be randomly allocated into two treatment groups.
Tooth color will be assessed using standardized clinical evaluation methods before treatment, immediately after bleaching, and during follow-up visits.
The study will also evaluate color stability and tooth sensitivity over a six-month follow-up period.
The findings are expected to provide evidence regarding the effectiveness and safety of both bleaching systems and to support evidence-based clinical decision-making in esthetic dentistry.
Undersøgelsestype
Interventionel
Tilmelding (Anslået)
50
Fase
- Ikke anvendelig
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiekontakt
- Navn: Esraa Eid, MSc
- Telefonnummer: +20 1019243773
- E-mail: esraa.korny@nub.edu.eg
Studiesteder
-
-
Minya Governorate
-
Minya, Minya Governorate, Egypten
- Rekruttering
- Minia University Hospital
-
Kontakt:
- Esraa Eid, MSc
- Telefonnummer: +20 1019243773
- E-mail: esraa.korny@nub.edu
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
Tager imod sunde frivillige
Ja
Beskrivelse
Inclusion Criteria:
- Adults aged 18-45 years.
- Good general health.
- Presence of all maxillary anterior teeth free from restorations, caries, or structural defects.
- Baseline tooth shade suitable for bleaching assessment.
- Good oral hygiene and periodontal health.
- Willingness to comply with the study protocol and attend all follow-up visits.
- Signed informed consent.
Exclusion Criteria:
- Pregnancy or lactation.
- History of tooth hypersensitivity.
- Active caries or defective restorations in the anterior teeth.
- Intrinsic tooth discoloration (e.g., fluorosis, tetracycline staining).
- Ongoing orthodontic treatment.
- Smoking.
- Use of tooth-whitening products within the previous 6 months.
- Allergy to any component of the bleaching materials.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Enkelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: Peroxide-based in office bleaching
Participants will receive a peroxide-based in-office tooth bleaching treatment according to the manufacturer's instructions.
|
Participants will receive an in-office peroxide-based tooth bleaching treatment using the bleaching system according to the manufacturer's instructions.
|
|
Eksperimentel: Non-peroxide-based in office bleaching
Participants will receive a non-peroxide-based in-office tooth bleaching treatment according to the manufacturer's instructions.
|
Participants will receive an in-office non- peroxide-based tooth bleaching treatment using the bleaching system according to the manufacturer's instructions.
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Bleaching efficacy measured by Whiteness Index for Dentistry (WID)
Tidsramme: Baseline, immediately after treatment, 1 month, 3 months, and 6 months after treatment
|
Bleaching efficacy will be assessed using the Whiteness Index for Dentistry (WID) obtained by spectrophotometric measurements of the anterior teeth.
|
Baseline, immediately after treatment, 1 month, 3 months, and 6 months after treatment
|
|
Color durability measured by CIEDE2000 color difference (ΔE00)
Tidsramme: Baseline, immediately after treatment, 1 month, 3 months, and 6 months after treatment
|
Color durability will be evaluated using spectrophotometric color measurements and expressed as CIEDE2000 color difference (ΔE00).
|
Baseline, immediately after treatment, 1 month, 3 months, and 6 months after treatment
|
|
Tooth sensitivity assessed using the Visual Analog Scale (VAS)
Tidsramme: Daily during the 14-day treatment period
|
ooth sensitivity will be evaluated using a 0-10 Visual Analog Scale (VAS), where 0 indicates no pain and 10 indicates the worst possible pain
|
Daily during the 14-day treatment period
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Anslået)
15. august 2026
Primær færdiggørelse (Anslået)
15. februar 2027
Studieafslutning (Anslået)
15. marts 2027
Datoer for studieregistrering
Først indsendt
8. september 2026
Først indsendt, der opfyldte QC-kriterier
8. september 2026
Først opslået (Faktiske)
14. september 2026
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
14. september 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
8. september 2026
Sidst verificeret
1. september 2026
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- MU-1301-2026
- 1301/2026 (Anden identifikator: Research Ethics Committee, Faculty of Dentistry, Minia University)
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
INGEN
IPD-planbeskrivelse
individual participant data will not be shared because there is no plan for public data sharing beyond the analyses and results reported in the study.
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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