Sleep Restriction and Energy Expenditure

Inclusion Criteria:

• Age 21-45 yrs
• Non-pregnant, non-lactating female subjects
• Body mass index (BMI) 25-28 kg/m2
• Weight stable (± 2.5 kg) for at least 3 mo prior to evaluation
• If a woman of child-bearing potential, must be willing to adhere to an acceptable form of contraception
• Non-smoker
• Regularly sleeps 7-8.5 hours/night
• If taking any form of medication, other than those listed in the exclusion criteria, must have been stable and remain on the same medication and medication dose throughout the study

Exclusion Criteria:

• Diabetes, uncontrolled hypertension
• Attempted to lose weight in past 3 months
• Eating disorder
• Stroke, seizure disorder, or other significant neurological disease;
• HIV positive by self-report
• Unstable or uncontrolled medical illness including active malignancies within past 5 yrs
• Untreated or unstable hypothyroidism
• Hyperthyroidism
• A score on the Brief Psychiatric Inventory that exceeds the 90th percentile;
• Subjects with psychoses, bipolar disorder, major depression, severe personality disorders, suicidal
• Alcohol or substance abuse in the past 6 mo
• Pregnant, planning pregnancy in the next 6 mo, or breast-feeding
• Participating in a commercial diet or behavior modification program (e.g., Weight Watchers), or plans to participate
• Shift worker, commercial long-distance driver, heavy equipment operator, history of drowsy driving
• Takes naps regularly
• Has traveled across time zones in the past 4 weeks or plans to during the weeks of the study
• Excessive caffeine intake