- ICH GCP
- Registre américain des essais cliniques
- Essai clinique NCT00005171
Cardiovascular Risk Factors in United States Adolescents and Adults
Aperçu de l'étude
Statut
Les conditions
Description détaillée
BACKGROUND:
In 1985 when the study was initiated, there were surprisingly little data on the distribution of risk factors among subgroups of the population and the changes occurring over time. These issues assumed greater importance as the decline in coronary heart disease mortality focused interest on the role of primary prevention through alteration of risk factors. In review of the potential contributions to this decline, it was noted that cessation of cigarette smoking, better blood pressure control and decrease in total serum cholesterol may have accounted partially for the decline in coronary heart disease mortality. However, these observations overlooked the possibility that observations in the total population or confined to specific socioeconomic groups may fail to disclose differential changes in particular population segments. For example, Americans in the higher educational and income groups experienced rapid and marked changes in risk behaviors while less educated, lower income Americans or specific racial/ethnic groups experienced no beneficial changes. The majority of cohort studies followed rather select groups and most cross-sectional surveys also had little sociodemographic variability. However, focusing public health, educational and medical intervention efforts required that particular groups at greater risk or experiencing less beneficial secular change be identified and targeted for greater efforts.
DESIGN NARRATIVE:
Trends in blood pressure, serum lipids, and cigarette smoking were described in nationally representative samples of adolescents ages 12 to 17 and in young adults ages 18 to 24 using data from surveys conducted from 1960 to 1984 by the National Center for Health Statistics (NCHS). Trends in blood pressure, serum lipids, cigarette smoking, and obesity were described in nationally representative samples of older adults ages 35 to 75 using NCHS survey data. The national surveys used included National Health Examination Surveys (NHES-I and III), the National Health and Nutrition Examination Surveys (NHANES I and II) and Hispanic NHANES. The secular trends in these risk factors were contrasted by subgroupings of age, race, sex, family income, and education. The correlates of these risk factors were determined and secular changes over time were identified and quantified. Risk factor values and their correlates in the national population sample were contrasted with the three Hispanic populations surveyed in the Hispanic Health and Nutrition Examination Survey (HHANES). Statistical methodologies were refined including statistical software for the analysis of complete sample survey data, model fitting strategies to characterize the secular trends across four national surveys, and guidelines for the choice of analytical strategies.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
Type d'étude
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
La description
Plan d'étude
Comment l'étude est-elle conçue ?
Collaborateurs et enquêteurs
Publications et liens utiles
Publications générales
- Flegal KM, Harlan WR, Landis JR. Secular trends in body mass index and skinfold thickness with socioeconomic factors in young adult men. Am J Clin Nutr. 1988 Sep;48(3):544-51. doi: 10.1093/ajcn/48.3.544.
- Flegal KM, Harlan WR, Landis JR. Secular trends in body mass index and skinfold thickness with socioeconomic factors in young adult women. Am J Clin Nutr. 1988 Sep;48(3):535-43. doi: 10.1093/ajcn/48.3.535.
- Landis JR, Flegal KM. A generalized Mantel-Haenszel analysis of the regression of blood pressure on blood lead using NHANES II data. Environ Health Perspect. 1988 Jun;78:35-41. doi: 10.1289/ehp.887835.
- Harlan WR, Landis JR, Flegal KM, Davis CS, Miller ME. Secular trends in body mass in the United States, 1960-1980. Am J Epidemiol. 1988 Nov;128(5):1065-74. doi: 10.1093/aje/128.5.1065.
- Miller ME, Davis CS, Landis JR. The analysis of longitudinal polytomous data: generalized estimating equations and connections with weighted least squares. Biometrics. 1993 Dec;49(4):1033-44.
- Basu S, Landis JR. Model-based estimation of population attributable risk under cross-sectional sampling. Am J Epidemiol. 1995 Dec 15;142(12):1338-43. doi: 10.1093/oxfordjournals.aje.a117602.
- Kumanyika SK, Landis JR, Matthews YL, Weaver SL, Harlan LC, Harlan WR. Secular trends in blood pressure among adult blacks and whites aged 18-34 years in two body mass index strata, United States, 1960-1980. Am J Epidemiol. 1994 Jan 15;139(2):141-54. doi: 10.1093/oxfordjournals.aje.a116976.
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude
Achèvement primaire
Achèvement de l'étude (Réel)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Estimation)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Estimation)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- 1046
- R01HL033407 (Subvention/contrat des NIH des États-Unis)
Informations sur les médicaments et les dispositifs, documents d'étude
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