- ICH GCP
- Registre américain des essais cliniques
- Essai clinique NCT01321008
Stage I/II Nasal NK Cell Lymphoma
Radiation Therapy Followed by Chemotherapy for Newly Diagnosed Patients With Stage I/II Nasal NK Cell Lymphoma
Aperçu de l'étude
Statut
Les conditions
Intervention / Traitement
Description détaillée
The Study Treatments:
Radiation therapy is designed to kill cancer cells or to stop cancer cells from growing.
CHOP chemotherapy is made up of the drugs cyclophosphamide, hydroxydaunorubicin (doxorubicin), oncovin (vincristine), and prednisone. It is designed to help control the tumor locally as well as the tumor cells that might have escaped and moved through the body.
Radiation Therapy:
You will receive radiation therapy 5 days a week for 28 to 30 treatments. You will receive a separate consent form that will describe this procedure and its risks in more detail.
Study Visits During Radiation Therapy:
Every week for 6 weeks during radiation therapy:
- You will be asked how you are feeling and about any side effects you may be having.
- Your performance status will be recorded.
- You will have a physical exam.
Chemotherapy Administration:
The amount of time after you finish radiation therapy before you can begin receiving chemotherapy will depend on your recovery time and any side effects you may have. This should be about 3-4 weeks.
On Day 1 you will receive cyclophosphamide by vein over 1 hour, doxorubicin by vein over 15 minutes, and vincristine by vein over 15 minutes. You will take prednisone by mouth on Days 1-5 of each cycle. Each cycle will be 21-days long (or longer if it takes longer for your blood counts to recover). You will receive up to 4 cycles of chemotherapy.
Study Visits During Chemotherapy:
Before Day 1 of Cycle 1:
- You will have a CT scan of head, neck, chest, abdomen and pelvis.
- You will have an Magnetic resonance imaging (MRI) scan of the head and neck.
- You will be asked about any drugs you may be taking and symptoms you may be having.
- Your performance status will be recorded.
- You will have a physical exam, including measurement of your height and weight.
- You will have an echocardiogram (ECHO) and MUltiple Gated Acquisition scan (MUGA) scan.
- You will have an x-ray of the chest.
- You will have an Electrocardiography (ECG).
- Blood (about 2 teaspoons) will be drawn for routine tests.
- If you are able to become pregnant, you will have a blood (about 2 teaspoons) pregnancy test.
On Day 15 of Cycle 1:
- You will be asked about any drugs you may be taking and symptoms you may be having.
- Your performance status will be recorded.
- Blood (about 2 teaspoons) will be drawn for routine tests.
On Day 1 of Cycles 2-4:
- You will be asked about any drugs you may be taking and symptoms you may be having.
- Your performance status will be recorded.
- You will have an ECG.
- Blood (about 2 teaspoons) will be drawn for routine tests.
On Day 15 of Cycles 2-4:
-Blood (about 2 teaspoons) will be drawn for routine tests.
Length of Study:
You may receive radiation and up to 4 cycles of CHOP. You will no longer be able to receive CHOP if the disease gets worse or intolerable side effects occur.
Your participation on the study will be over after the end-of-study and follow-up visits.
Follow-Up and End-of-Study Visits:
If you leave the study early:
- You will have a computed tomography (CT) scan of head, neck, chest, abdomen and pelvis.
- You will have an MRI scan of the head and neck.
- You will have a positron emission tomography (PET)/CT scan.
- Any skin lesions that you may have that are related to the tumor will be measured and photographed.
- You will be asked about any drugs you may be taking and symptoms you may be having.
- Your performance status will be recorded.
- You will have a physical exam.
- Blood (about 2 teaspoons) will be drawn for routine tests.
Routine Follow-up:
- You will also have routine follow-up visits every 3 months for the 1st year, every 4 month during the 2nd year, and every 6 months during the 3rd-5th years. After that, you will have follow up visits 1 time every year. At these visits, the following tests and procedures will be recorded:
- You will have a CT scan of head, neck, chest, abdomen and pelvis.
- You will have an MRI scan of the head and neck.
- You will have a PET/CT scan.
- You will be asked about any symptoms you may be having.
- Blood (about 2 teaspoons) will be drawn for routine tests.
Up to 40 patients will take part in this study. All will be enrolled at University of Texas (UT) MD Anderson Cancer Center.
Type d'étude
Inscription (Réel)
Phase
- Phase 2
- La phase 1
Contacts et emplacements
Lieux d'étude
-
-
Texas
-
Houston, Texas, États-Unis, 77030
- UT MD Anderson Cancer Center
-
-
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
La description
Inclusion Criteria:
- Patients with newly diagnosed stage I and II nasal Natural Killer (NK) cell lymphoma.
- Adequate blood cell counts (i.e. Absolute neutrophil count (ANC)> 1000) at baseline, or willingness to accept supportive measures such as transfusions, filgrastim, and Epoetin. Epoetin will not be administered concurrently with radiation.
- Patients must have adequate liver function as indicated by: *Bilirubin </= 1.5 times the upper limit of normal (ULN), * Alanine transaminase (ALT) </= 2 times the (ULN) or aspartate transaminase (AST) ≤ 2 times the ULN, *These values must be obtained within two weeks before protocol entry.
- Patients are required to have adequate renal function as indicated by a serum creatinine </= 2.5 mg/dL.This value must be obtained within two weeks before protocol entry.
- Left ventricular ejection fraction must be evaluated by nuclear medicine scan or echocardiography and measure >/= 50%.
- Male patients must agree to use a barrier method of contraception or agree to abstain from heterosexual activity for the duration of the study.
- Female patients must be willing to use two adequate barrier methods of contraception to prevent pregnancy or agree to abstain from heterosexual activity throughout the study or be post menopausal (free from menses > two years or surgically sterilized).
- Female patients of childbearing potential must have a negative serum pregnancy test (BhCG) within 2 weeks of protocol entry.
- Patients must have the ability to give informed consent.
Exclusion Criteria:
- Patients with active Hepatitis B and/or Hepatitis C infection.
- Patients with active infections requiring specific anti-infective therapy are not eligible until all signs of infections are resolved.
- Patients known to be HIV positive.
- Patients with pre-existing cardiovascular disease requiring ongoing treatment. This includes: a) Congestive heart failure class III/IV (CHF) per new york heart association (NYHA) criteria. b) Cardiomyopathy, c) Uncontrolled cardiac arrhythmia, d) Unstable angina pectoris, e) Recent Myocardial infarction (MI) (within 6 months).
- Patients with prior exposure to anthracyclines:
- Patients who are pregnant or breast-feeding.
- Patients with psychiatric illness and/or social situations that would limit compliance with the study medication and requirements.
- Prior radiation to the site of current primary disease, if re-treatment would lead to violation of known radiation dose tolerance limits for that site.
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Traitement
- Répartition: N / A
- Modèle interventionnel: Affectation à un seul groupe
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
---|---|
Expérimental: Radiation + Chemotherapy
Radiation therapy total dose of 50.4 to 54 Gy over 28 to 30 treatments; CHOP Chemotherapy of Cyclophosphamide 750 mg/m2 intravenous piggyback (IVPB), Doxorubicin 50 mg/m2 IVPB, Vincristine 1.4 mg/m2 (max dose 2 mg) IVPB on Day 1, and Oral Prednisone 100 mg daily days 1-5 for four 21-day cycles.
|
50.4 to 54 Gy delivered 5 days a week for 28 to 30 treatments.
Autres noms:
750 mg/m2 by vein over 1 hour on Day 1 of a 21 day cycle.
Autres noms:
50 mg/m2 by vein over 15 minutes on Day 1 of a 21 day cycle.
Autres noms:
1.4 mg/m2 (max dose 2 mg) by vein over 15 minutes on Day 1 of a 21 day cycle.
Autres noms:
100 mg by mouth daily on Days 1-5 of a 21 day cycle.
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
---|---|---|
Progression-free Survival (PFS)
Délai: Day 1 to disease progression or death (up to 5+ years)
|
Progression-free survival (PFS) defined as time from treatment initiation day to first documented progressive disease or death due to disease.
Reviewed with each 21-day treatment cycle, followed every 3-4 months for first 2 years, annually thereafter.
|
Day 1 to disease progression or death (up to 5+ years)
|
Collaborateurs et enquêteurs
Parrainer
Les enquêteurs
- Chercheur principal: Bouthaina Dabaja, MD, UT MD Anderson Cancer Center
Publications et liens utiles
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude
Achèvement primaire (Réel)
Achèvement de l'étude (Réel)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Estimation)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Estimation)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Mots clés
Termes MeSH pertinents supplémentaires
- Maladies du système immunitaire
- Tumeurs par type histologique
- Tumeurs
- Troubles lymphoprolifératifs
- Maladies lymphatiques
- Troubles immunoprolifératifs
- Lymphome
- Effets physiologiques des médicaments
- Mécanismes moléculaires de l'action pharmacologique
- Inhibiteurs d'enzymes
- Agents anti-inflammatoires
- Agents antirhumatismaux
- Agents antinéoplasiques
- Agents immunosuppresseurs
- Facteurs immunologiques
- Modulateurs de tubuline
- Agents antimitotiques
- Modulateurs de mitose
- Glucocorticoïdes
- Les hormones
- Hormones, substituts hormonaux et antagonistes hormonaux
- Agents antinéoplasiques, hormonaux
- Agents antinéoplasiques, alkylants
- Agents d'alkylation
- Agonistes myéloablatifs
- Agents antinéoplasiques phytogéniques
- Inhibiteurs de la topoisomérase II
- Inhibiteurs de la topoisomérase
- Antibiotiques, Antinéoplasiques
- Cyclophosphamide
- Prednisone
- Doxorubicine
- Vincristine
Autres numéros d'identification d'étude
- 2010-0035
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .
Essais cliniques sur Radiation
-
University Hospital Southampton NHS Foundation...ComplétéMaladie de l'artère coronaireRoyaume-Uni, Irlande
-
Seoul National University HospitalComplétéSténose de l'artère coronaire
-
Ajou University School of MedicineRésiliéSténose de l'artère coronaireCorée, République de
-
Seoul National University HospitalInje University; Keimyung University; Ajou UniversityInconnueSténose de l'artère coronaireCorée, République de