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Evaluating and Treating Potential Research Participants With Digestive Disorders

23 novembre 2019 mis à jour par: National Institute of Nursing Research (NINR)

Evaluation and Treatment Protocol for Potential Research Participants With Digestive Disorders

Background:

- Some research studies focus on digestive disorders, such as nutritional, gastrointestinal, and liver disorders. Researchers want to examine and treat people with digestive disorders in order to learn more about these disorders. They also want to study how digestive disorders run in some families. To do so, they will provide standard care to people with digestive disorders. They will also look at relatives of people with digestive disorders, such as parents, children, and siblings.

Objectives:

  • To examine and treat people with digestive disorders.
  • To evaluate people with digestive disorders for research studies.

Eligibility:

  • Individuals of any age who have digestive disorders.
  • Individuals at least 2 years of age who are first-degree relatives of the people with digestive disorders.

Design:

  • Participants will have at least one outpatient visit to the National Institutes of Health. The visit will last about 2 hours.
  • All participants will be screened with a physical exam and medical history. They will also provide different samples for study. Samples may include blood, urine, and stool samples. Saliva and hair samples may also be taken. Skin biopsies and rectal swabs may be collected from adult participants.
  • Participants with digestive disorders may be able to receive treatment through this study.

Aperçu de l'étude

Statut

Résilié

Les conditions

Intervention / Traitement

Description détaillée

The National Institute of Nursing Research (NINR) is conducting a protocol to evaluate and provide standard treatment to participants with various diagnosed and undiagnosed digestive conditions. Investigators of this protocol provide GI consultation at the NIH Clinical Center for a range of GI conditions.

Objectives: The primary objective of this protocol is to allow digestive care specialists in NINR and other institutions to provide standard of care. Evaluating and treating participants will allow digestive care specialists to maintain their expertise and gain additional knowledge of the course of various digestive disorders. Additionally this protocol will allow for hypothesis generation and provide a resource of patients for enrollment into new research protocols throughout the NINR branches. The information obtained will allow for the evaluation of standard treatments of the studied digestive diseases. This understanding may lead to ideas for future protocols. The protocol will also allow for trainees to receive training in the management of digestive disorders.

Study Population: The number of participants for this evaluation and treatment protocol will be set to 500 patients with digestive disorders and their unaffected first-degree relatives.

Design: This is a natural history evaluation and treatment protocol of the progression and physiology of multiple digestive disorders. Blood or other biologic samples (including but not limited to stool, urine, saliva, hair, cheek swab, or tissue) will be obtained through non-invasive means or incidentally to clinical care for future laboratory studies. In addition, genetic samples may be collected from unaffected first-degree relatives and may be used to identify and verify causative mutations.

Outcome Measures: The outcome measures for this protocol are the clinical assessments of enrolled participants, including their response to standard treatments. Also, causative mutations may help establish pathogenic mechanisms and genotype-phenotype correlations.

Type d'étude

Interventionnel

Inscription (Réel)

225

Phase

  • N'est pas applicable

Contacts et emplacements

Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.

Lieux d'étude

  • États-Unis
    • Maryland
      • Bethesda, Maryland, États-Unis, 20892
        • National Institutes of Health Clinical Center, 9000 Rockville Pike

Critères de participation

Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.

Critère d'éligibilité

Âges éligibles pour étudier

2 ans et plus (Enfant, Adulte, Adulte plus âgé)

Accepte les volontaires sains

Oui

Sexes éligibles pour l'étude

Tout

La description

  • INCLUSION CRITERIA:

This protocol will include participants from birth and has no upper age limit.

Participants will be eligible if they:

  1. Have either a digestive disorder, OR
  2. Are an unaffected first-degree relative ( >2 years old) of a participant with a digestive disorder.

EXCLUSION CRITERIA:<TAB>

Participants will not be eligible if they:

  1. Are unwilling to give informed consent or, if a minor, do not have a parent or guardian able to provide consent, cannot assign a Durable Power of Attorney (DPA) or if a minor, do not have a parent or guardian able to provide consent.
  2. Have a systemic disease that, in the judgment of the investigators, compromises the ability to obtain research data.
  3. NINR employees, subordinates/relatives/ or co-workers
  4. Any NIH employess who is a subordinate/relative/or co-worker of a study investigator

Plan d'étude

Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.

Comment l'étude est-elle conçue ?

Détails de conception

  • Objectif principal: Traitement
  • Répartition: N / A
  • Modèle interventionnel: Affectation à un seul groupe
  • Masquage: Aucun (étiquette ouverte)

Armes et Interventions

Groupe de participants / Bras
Intervention / Traitement
Autre: 1
Standard of Care. Participants will be evaluated and treated for their particular digestive disorder or presenting symptoms.
Autre: Standard of Care
Any evaluation or treatment under this protocol will be based on standard practice as related to the subjects's digestive disorder.These include but are not limited to biobehavioral interventions including bowel retraining, biofeedback, and other lifestyle interventions, all of which have been shown to be beneficial in the treatment of this type of chronic functional bowel disorder.

Que mesure l'étude ?

Principaux critères de jugement

Mesure des résultats
Description de la mesure
Délai
Evaluation and treatment of GI disorders
Délai: Outcomes will be assessed periodically according to disorder and severity.
This protocol allows NINR investigators to provide treatment for GI disorders and maintain knowledge and expertise of GI disorders.
Outcomes will be assessed periodically according to disorder and severity.

Collaborateurs et enquêteurs

C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.

Parrainer

National Institute of Nursing Research (NINR)

Les enquêteurs

  • Chercheur principal: Wendy A Henderson, C.R.N.P., National Institute of Nursing Research (NINR)

Dates d'enregistrement des études

Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.

Dates principales de l'étude

Début de l'étude

17 septembre 2012

Achèvement primaire (Réel)

21 novembre 2019

Achèvement de l'étude (Réel)

21 novembre 2019

Dates d'inscription aux études

Première soumission

27 novembre 2012

Première soumission répondant aux critères de contrôle qualité

27 novembre 2012

Première publication (Estimation)

29 novembre 2012

Mises à jour des dossiers d'étude

Dernière mise à jour publiée (Réel)

26 novembre 2019

Dernière mise à jour soumise répondant aux critères de contrôle qualité

23 novembre 2019

Dernière vérification

21 novembre 2019

Plus d'information

Termes liés à cette étude

Mots clés

Termes MeSH pertinents supplémentaires

Autres numéros d'identification d'étude

  • 120195
  • 12-NR-0195

Informations sur les médicaments et les dispositifs, documents d'étude

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Non

Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .

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