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- Essai clinique NCT03139682
Microvascular Injury and Blood-brain Barrier Dysfunction as Novel Biomarkers and Targets for Treatment in Traumatic Brain Injury
Aperçu de l'étude
Statut
Type d'étude
Inscription (Anticipé)
Contacts et emplacements
Coordonnées de l'étude
- Nom: Lorelei Audas, BScN
- Numéro de téléphone: 902-473-2397
- E-mail: lorelei.audas@nshealth.ca
Sauvegarde des contacts de l'étude
- Nom: Tamara Mitterer, BScN
- Numéro de téléphone: 902-473-7883
- E-mail: tamara.mitterer@nshealth.ca
Lieux d'étude
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Nova Scotia
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Halifax, Nova Scotia, Canada, B3H 3A7
- Recrutement
- Halifax Infirmary
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Contact:
- David B. Clarke, MDCM, PhD, FRCSC, DABNS, FACS
- Numéro de téléphone: 902-473-4591
- E-mail: d.clarke@dal.ca
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Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
Méthode d'échantillonnage
Population étudiée
La description
Inclusion Criteria:
- Age 18 - 85 inclusive
- Clinically diagnosed TBI or evidence of TBI
For mild TBI, as defined by the American Congress on Rehabilitation Medicine (1993), clear evidence and/or documentation of blunt head injury and any one of the following:
- any loss of consciousness up to 30 min
- any loss of memory for events immediately before or after the injury as much as 24 h
- any alteration of mental state at the time of the injury
- focal neurologic deficits that might or might not be transient
but where the severity of the injury does not exceed oss of consciousness exceeding 30 min, posttraumatic amnesia longer than 24 h, a Glasgow Coma Scale score falling below 13 after 30 min.
- For moderate TBI (GCS 9-12) and severe TBI (GCS 4-8) CT evidence of TBI-linked abnormality (intracranial lesion including traumatic SAH, contusion, extra-axial hematoma). For patients who are intubated, use best documented GCS within first 48 hours of injury.
- Stable respiratory or hemodynamic status allowing MRI within 2-4 days of TBI as determined by the attending physician
- Patient or substitute decision maker can provide consent
Exclusion Criteria:
- Pre-existing known neurologic, psychiatric disease (dementia, prior severe TBI, schizophrenia, uncontrolled epilepsy, major depressive disorder, stroke, multiple sclerosis, brain tumor)
- Serious infection, complications (sepsis, multilobe pneumonia, etc.) < 4 days after TBI
- Acute ischemic heart disease (MI or unstable angina)
- SBP < 100 mm Hg, DBP < 60 mm Hg
- MRI contraindications; patient has metal implant, pacemaker, biostimulator, neurostimulator, internal defibrillator, history of metal in eye, inner ear implant, cerebral aneurism clip, joint replacement, any known metal in their body, or are pregnant or breast feeding
- History or evidence of active malignancy
- History or evidence of serious kidney (GFR =<60) , heart, or liver disease
- Pregnant or breast-feeding women
- Inability to complete follow up visits (e.g. tourists)
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Modèles d'observation: Cohorte
- Perspectives temporelles: Éventuel
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
---|---|---|
Change in brain volume with blood brain barrier dysfunction
Délai: At < 4, 10 ± 2, and 90 ± 10 days post-injury
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Measurement of change in brain volume with BBBD and extent of permeability change as measured by DCE-MRI
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At < 4, 10 ± 2, and 90 ± 10 days post-injury
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Change in serum biomarkers of blood brain barrier dysfunction
Délai: At < 4, 10 ± 2, and 90 ± 10 days post-injury
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Measurement of change in serum biomarkers of BBBD / neural injury (vWF, BDNF, GFAP, S100β, sTau, and sNFL)
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At < 4, 10 ± 2, and 90 ± 10 days post-injury
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Change in Glasgow Outcome Scale-Extended (GOS-E)
Délai: At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
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The GOS-E is intended to provide a general index of overall outcome that is sensitive to small but clinically relevant treatment effects in people who sustain TBI.
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At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
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Change in Rivermead Post Concussion Symptom Questionnaire (RPSQ)
Délai: At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
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The RPSQ is a 16-item self-report measure administered to individual(s) who sustained a TBI in order to measure the severity of symptoms and assess progress.
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At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
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Change in Patient-Reported Outcomes Measurement Information System (PROMIS)
Délai: At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
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PROMIS is a set of person-centered measures that evaluates and monitors domains such as physical, mental and social health in adults and children.
For this study, we will utilize the following domains: depression, fatigue, and pain interference.
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At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
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Change in post-traumatic epilepsy
Délai: At 10 ± 2 days, 90 ± 10 days, 1 year, and 2 years post-injury
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Screening for post-traumatic epilepsy
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At 10 ± 2 days, 90 ± 10 days, 1 year, and 2 years post-injury
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Collaborateurs et enquêteurs
Parrainer
Les enquêteurs
- Chercheur principal: David B. Clarke, MD, PhD, Nova Scotia Health Authority
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Réel)
Achèvement primaire (Anticipé)
Achèvement de l'étude (Anticipé)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Réel)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- TMI_BBBD_2017
Informations sur les médicaments et les dispositifs, documents d'étude
Étudie un produit pharmaceutique réglementé par la FDA américaine
Étudie un produit d'appareil réglementé par la FDA américaine
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Essais cliniques sur Lésion cérébrale traumatique
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Kessler FoundationInstituto Vocacional Enrique Díaz de León A.C., Guadalajara, MexicoRecrutementTBI (Traumatic Brain Injury) ou MS (Sclérose en Plaques)États-Unis, Espagne