- ICH GCP
- Registro degli studi clinici negli Stati Uniti
- Sperimentazione clinica NCT03139682
Microvascular Injury and Blood-brain Barrier Dysfunction as Novel Biomarkers and Targets for Treatment in Traumatic Brain Injury
Panoramica dello studio
Stato
Tipo di studio
Iscrizione (Anticipato)
Contatti e Sedi
Luoghi di studio
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Nova Scotia
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Halifax, Nova Scotia, Canada, B3H 3A7
- Reclutamento
- Halifax Infirmary
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Contatto:
- David B. Clarke, MDCM, PhD, FRCSC, DABNS, FACS
- Numero di telefono: 902-473-4591
- Email: d.clarke@dal.ca
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Criteri di partecipazione
Criteri di ammissibilità
Età idonea allo studio
Accetta volontari sani
Sessi ammissibili allo studio
Metodo di campionamento
Popolazione di studio
Descrizione
Inclusion Criteria:
- Age 18 - 85 inclusive
- Clinically diagnosed TBI or evidence of TBI
For mild TBI, as defined by the American Congress on Rehabilitation Medicine (1993), clear evidence and/or documentation of blunt head injury and any one of the following:
- any loss of consciousness up to 30 min
- any loss of memory for events immediately before or after the injury as much as 24 h
- any alteration of mental state at the time of the injury
- focal neurologic deficits that might or might not be transient
but where the severity of the injury does not exceed oss of consciousness exceeding 30 min, posttraumatic amnesia longer than 24 h, a Glasgow Coma Scale score falling below 13 after 30 min.
- For moderate TBI (GCS 9-12) and severe TBI (GCS 4-8) CT evidence of TBI-linked abnormality (intracranial lesion including traumatic SAH, contusion, extra-axial hematoma). For patients who are intubated, use best documented GCS within first 48 hours of injury.
- Stable respiratory or hemodynamic status allowing MRI within 2-4 days of TBI as determined by the attending physician
- Patient or substitute decision maker can provide consent
Exclusion Criteria:
- Pre-existing known neurologic, psychiatric disease (dementia, prior severe TBI, schizophrenia, uncontrolled epilepsy, major depressive disorder, stroke, multiple sclerosis, brain tumor)
- Serious infection, complications (sepsis, multilobe pneumonia, etc.) < 4 days after TBI
- Acute ischemic heart disease (MI or unstable angina)
- SBP < 100 mm Hg, DBP < 60 mm Hg
- MRI contraindications; patient has metal implant, pacemaker, biostimulator, neurostimulator, internal defibrillator, history of metal in eye, inner ear implant, cerebral aneurism clip, joint replacement, any known metal in their body, or are pregnant or breast feeding
- History or evidence of active malignancy
- History or evidence of serious kidney (GFR =<60) , heart, or liver disease
- Pregnant or breast-feeding women
- Inability to complete follow up visits (e.g. tourists)
Piano di studio
Come è strutturato lo studio?
Dettagli di progettazione
- Modelli osservazionali: Coorte
- Prospettive temporali: Prospettiva
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
---|---|---|
Change in brain volume with blood brain barrier dysfunction
Lasso di tempo: At < 4, 10 ± 2, and 90 ± 10 days post-injury
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Measurement of change in brain volume with BBBD and extent of permeability change as measured by DCE-MRI
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At < 4, 10 ± 2, and 90 ± 10 days post-injury
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Change in serum biomarkers of blood brain barrier dysfunction
Lasso di tempo: At < 4, 10 ± 2, and 90 ± 10 days post-injury
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Measurement of change in serum biomarkers of BBBD / neural injury (vWF, BDNF, GFAP, S100β, sTau, and sNFL)
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At < 4, 10 ± 2, and 90 ± 10 days post-injury
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Change in Glasgow Outcome Scale-Extended (GOS-E)
Lasso di tempo: At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
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The GOS-E is intended to provide a general index of overall outcome that is sensitive to small but clinically relevant treatment effects in people who sustain TBI.
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At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
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Change in Rivermead Post Concussion Symptom Questionnaire (RPSQ)
Lasso di tempo: At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
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The RPSQ is a 16-item self-report measure administered to individual(s) who sustained a TBI in order to measure the severity of symptoms and assess progress.
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At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
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Change in Patient-Reported Outcomes Measurement Information System (PROMIS)
Lasso di tempo: At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
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PROMIS is a set of person-centered measures that evaluates and monitors domains such as physical, mental and social health in adults and children.
For this study, we will utilize the following domains: depression, fatigue, and pain interference.
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At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
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Change in post-traumatic epilepsy
Lasso di tempo: At 10 ± 2 days, 90 ± 10 days, 1 year, and 2 years post-injury
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Screening for post-traumatic epilepsy
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At 10 ± 2 days, 90 ± 10 days, 1 year, and 2 years post-injury
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Collaboratori e investigatori
Sponsor
Investigatori
- Investigatore principale: David B. Clarke, MD, PhD, Nova Scotia Health Authority
Studiare le date dei record
Studia le date principali
Inizio studio (Effettivo)
Completamento primario (Anticipato)
Completamento dello studio (Anticipato)
Date di iscrizione allo studio
Primo inviato
Primo inviato che soddisfa i criteri di controllo qualità
Primo Inserito (Effettivo)
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
Ultimo aggiornamento inviato che soddisfa i criteri QC
Ultimo verificato
Maggiori informazioni
Termini relativi a questo studio
Termini MeSH pertinenti aggiuntivi
Altri numeri di identificazione dello studio
- TMI_BBBD_2017
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Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .
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