- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT03139682
Microvascular Injury and Blood-brain Barrier Dysfunction as Novel Biomarkers and Targets for Treatment in Traumatic Brain Injury
5. februar 2019 oppdatert av: David Clarke, Nova Scotia Health Authority
Traumatic brain injury (TBI) is a leading cause of death and disability around the world.
The social and economic burden of TBI is tremendous and the cost of TBI is estimated at $1 billion per year in Canada- $650 million in care and $580 million in lost productivity.
Novel interventions aimed at TBI-linked molecular targets have been successful in limiting injury and improving neurologic recovery in animal models, thus providing compelling evidence that effective intervention is possible after injury.
This study proposes to investigate traumatic microvascular injury (TMI) and specifically blood-brain barrier dysfunction (BBBD) as a candidate biomarker and therapeutic target in TBI.
Studieoversikt
Status
Ukjent
Studietype
Observasjonsmessig
Registrering (Forventet)
120
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiekontakt
- Navn: Lorelei Audas, BScN
- Telefonnummer: 902-473-2397
- E-post: lorelei.audas@nshealth.ca
Studer Kontakt Backup
- Navn: Tamara Mitterer, BScN
- Telefonnummer: 902-473-7883
- E-post: tamara.mitterer@nshealth.ca
Studiesteder
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Nova Scotia
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Halifax, Nova Scotia, Canada, B3H 3A7
- Rekruttering
- Halifax Infirmary
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Ta kontakt med:
- David B. Clarke, MDCM, PhD, FRCSC, DABNS, FACS
- Telefonnummer: 902-473-4591
- E-post: d.clarke@dal.ca
-
-
Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
18 år til 85 år (Voksen, Eldre voksen)
Tar imot friske frivillige
Nei
Kjønn som er kvalifisert for studier
Alle
Prøvetakingsmetode
Ikke-sannsynlighetsprøve
Studiepopulasjon
We will recruit mild (n=40), moderate (n=40) and severe (n=40) TBI patients with a TBI-linked abnormality (e.g.
epidural & subdural hematomas, subarachnoid hemorrhage, contusions).
TBI will be classified by severity using the Glasgow Coma Scale (GCS); mild TBI (GCS13-15), moderate TBI (GCS 9-12), and severe TBI (GCS <8).
Beskrivelse
Inclusion Criteria:
- Age 18 - 85 inclusive
- Clinically diagnosed TBI or evidence of TBI
For mild TBI, as defined by the American Congress on Rehabilitation Medicine (1993), clear evidence and/or documentation of blunt head injury and any one of the following:
- any loss of consciousness up to 30 min
- any loss of memory for events immediately before or after the injury as much as 24 h
- any alteration of mental state at the time of the injury
- focal neurologic deficits that might or might not be transient
but where the severity of the injury does not exceed oss of consciousness exceeding 30 min, posttraumatic amnesia longer than 24 h, a Glasgow Coma Scale score falling below 13 after 30 min.
- For moderate TBI (GCS 9-12) and severe TBI (GCS 4-8) CT evidence of TBI-linked abnormality (intracranial lesion including traumatic SAH, contusion, extra-axial hematoma). For patients who are intubated, use best documented GCS within first 48 hours of injury.
- Stable respiratory or hemodynamic status allowing MRI within 2-4 days of TBI as determined by the attending physician
- Patient or substitute decision maker can provide consent
Exclusion Criteria:
- Pre-existing known neurologic, psychiatric disease (dementia, prior severe TBI, schizophrenia, uncontrolled epilepsy, major depressive disorder, stroke, multiple sclerosis, brain tumor)
- Serious infection, complications (sepsis, multilobe pneumonia, etc.) < 4 days after TBI
- Acute ischemic heart disease (MI or unstable angina)
- SBP < 100 mm Hg, DBP < 60 mm Hg
- MRI contraindications; patient has metal implant, pacemaker, biostimulator, neurostimulator, internal defibrillator, history of metal in eye, inner ear implant, cerebral aneurism clip, joint replacement, any known metal in their body, or are pregnant or breast feeding
- History or evidence of active malignancy
- History or evidence of serious kidney (GFR =<60) , heart, or liver disease
- Pregnant or breast-feeding women
- Inability to complete follow up visits (e.g. tourists)
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Observasjonsmodeller: Kohort
- Tidsperspektiver: Potensielle
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
---|---|---|
Change in brain volume with blood brain barrier dysfunction
Tidsramme: At < 4, 10 ± 2, and 90 ± 10 days post-injury
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Measurement of change in brain volume with BBBD and extent of permeability change as measured by DCE-MRI
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At < 4, 10 ± 2, and 90 ± 10 days post-injury
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Change in serum biomarkers of blood brain barrier dysfunction
Tidsramme: At < 4, 10 ± 2, and 90 ± 10 days post-injury
|
Measurement of change in serum biomarkers of BBBD / neural injury (vWF, BDNF, GFAP, S100β, sTau, and sNFL)
|
At < 4, 10 ± 2, and 90 ± 10 days post-injury
|
Change in Glasgow Outcome Scale-Extended (GOS-E)
Tidsramme: At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
|
The GOS-E is intended to provide a general index of overall outcome that is sensitive to small but clinically relevant treatment effects in people who sustain TBI.
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At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
|
Change in Rivermead Post Concussion Symptom Questionnaire (RPSQ)
Tidsramme: At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
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The RPSQ is a 16-item self-report measure administered to individual(s) who sustained a TBI in order to measure the severity of symptoms and assess progress.
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At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
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Change in Patient-Reported Outcomes Measurement Information System (PROMIS)
Tidsramme: At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
|
PROMIS is a set of person-centered measures that evaluates and monitors domains such as physical, mental and social health in adults and children.
For this study, we will utilize the following domains: depression, fatigue, and pain interference.
|
At 10 ± 2 days, 90 ± 10 days, and 1 year post-injury
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Change in post-traumatic epilepsy
Tidsramme: At 10 ± 2 days, 90 ± 10 days, 1 year, and 2 years post-injury
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Screening for post-traumatic epilepsy
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At 10 ± 2 days, 90 ± 10 days, 1 year, and 2 years post-injury
|
Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Etterforskere
- Hovedetterforsker: David B. Clarke, MD, PhD, Nova Scotia Health Authority
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart (Faktiske)
3. august 2017
Primær fullføring (Forventet)
3. august 2019
Studiet fullført (Forventet)
3. august 2020
Datoer for studieregistrering
Først innsendt
26. april 2017
Først innsendt som oppfylte QC-kriteriene
1. mai 2017
Først lagt ut (Faktiske)
4. mai 2017
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
6. februar 2019
Siste oppdatering sendt inn som oppfylte QC-kriteriene
5. februar 2019
Sist bekreftet
1. februar 2019
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- TMI_BBBD_2017
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
Nei
Studerer et amerikansk FDA-regulert enhetsprodukt
Nei
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