- ICH GCP
- Registre américain des essais cliniques
- Essai clinique NCT05322369
Prevalence of Periodontitis in Diabetic Patients of Egyptian Population
Prevalence of Periodontitis in Diabetic Patients of Egyptian Population : A Cross Sectional Study.
Aperçu de l'étude
Statut
Les conditions
Intervention / Traitement
Description détaillée
Periodontitis is a common chronic inflammatory disease which is characterized by destruction of the supporting structures of the teeth especially the periodontal ligament and alveolar bone. Their classification is complex and takes into consideration many factors such as the clinical presentation, age at diagnosis, rate of disease progression, and systemic and local factors which may increase risk (Pihlstrom BL etal., 2005).
Tissue destruction in periodontitis results in the breakdown of the collagen fibers of the periodontal ligament, that results in the formation of a periodontal pocket between the gingiva and the tooth. "Pocketing" is not evident on simple visual inspection, and assessment using a periodontal probe is needed. Periodontitis is a slowly progressing disease, however the tissue destruction that happens is largely irreversible. The condition is asymptomatic in the early stages, it is not usually painful, and many patients are unaware till progression in the condition occurs and is enough to result in tooth mobility. As a result of the further destruction of fibers of the periodontal ligament (referred to as attachment loss), the pockets deepen, and the resorption of the alveolar bone occurs in parallel with the progressing attachment loss (Grossi SG etal., 1995).
Diabetes mellitus is a metabolic disorder which is characterized by hyperglycemia as a result of defective secretion or activity of insulin (Tan M etal., 1997). It may be further complicated by poor regulation of protein and lipid metabolism. In the current classification of this condition, the terms "insulin-dependent diabetes mellitus" and "non-insulin dependent diabetes mellitus" are not used, in part because they relate to treatment rather than to the diagnosis. A conclusive diagnosis of diabetes mellitus is done through assessment of glycated hemoglobin levels. In those people with diabetes, sequential fasting plasma glucose levels will be 7 mmol/L or more.
Type 1 diabetes mellitus normally occurs as a result of destruction of the beta cells in the islets of Langerhans of the pancreas by the autoimmune system. This condition often leads to absolute deficiency of insulin. Type 1 diabetes tends to occur in young, lean individuals, usually before 30 years of age; however, older patients may also present with this form of diabetes occasionaly.
With Type 2 diabetes, patients can still produce insulin but do so relatively inadequately. In many cases, the pancreas produces larger than normal quantities of insulin. A major feature of Type 2 diabetes is a lack of sensitivity to insulin by the cells of the body, especially fat and muscle cells. These larger quantities of insulin are produced as an attempt to get these cells to recognize that insulin is present.
There is emerging evidence to support the existence of a two-way relationship between diabetes and periodontitis, with diabetes increasing the risk for periodontitis, and periodontal inflammation negatively affecting glycemic control (Fox CH., 1992) & (Mealey BL & Ocampo GL, 2007).
Type d'étude
Inscription (Anticipé)
Contacts et emplacements
Coordonnées de l'étude
- Nom: Mahmoud R Reda, BDS
- Numéro de téléphone: +201002741736
- E-mail: mahmoud.refaiy@dentistry.cu.edu.eg
Sauvegarde des contacts de l'étude
- Nom: Weam A Ahmed, Professor
- Numéro de téléphone: +201283226072
- E-mail: weamrashwan@dentistry.cu.edu.eg
Lieux d'étude
-
-
-
Cairo, Egypte
- Faculty of dentistry Cairo University
-
Contact:
- Numéro de téléphone: (+202) 23634965
-
-
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
Méthode d'échantillonnage
Population étudiée
La description
Inclusion Criteria:
- Diabetic patients whether Type 1 or 2
- Patient consulting in the outpatient clinic
- Provide informed consent.
Exclusion Criteria:
- Participants who had <10 teeth currently or
- Those who had undergone any periodontal treatment within the past 1 year
- Patients suffering from any other metabolic or systemic diseses tht could affect the periodontal condition
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
---|---|---|
: Prevalence of Periodontitis in diabetics of Egyptian outpatients of faculty of dentistry cairo university.
Délai: Baseline
|
periodontal charting will be done for diabetic patients attending outpatient clinics
|
Baseline
|
Collaborateurs et enquêteurs
Parrainer
Les enquêteurs
- Chercheur principal: Mahmoud R Reda, BDS, Cairo University
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Anticipé)
Achèvement primaire (Anticipé)
Achèvement de l'étude (Anticipé)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Réel)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- Periodontitis in diabetics
Plan pour les données individuelles des participants (IPD)
Prévoyez-vous de partager les données individuelles des participants (DPI) ?
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .
Essais cliniques sur periodontal charting only
-
Universidad Rey Juan CarlosRecrutementMolaire, troisième | Poche parodontaleEspagne
-
Boston UniversityNational Cancer Institute (NCI); Brown University; National Institutes of Health... et autres collaborateursComplété
-
U.S. Army Medical Research and Development CommandUnited States Agency for International Development (USAID); IDRIComplété
-
Memorial Sloan Kettering Cancer CenterComplétéCancer du sein | Dissection des ganglions lymphatiques axillairesÉtats-Unis