- ICH GCP
- 미국 임상 시험 레지스트리
- 임상시험 NCT05322369
Prevalence of Periodontitis in Diabetic Patients of Egyptian Population
Prevalence of Periodontitis in Diabetic Patients of Egyptian Population : A Cross Sectional Study.
연구 개요
상세 설명
Periodontitis is a common chronic inflammatory disease which is characterized by destruction of the supporting structures of the teeth especially the periodontal ligament and alveolar bone. Their classification is complex and takes into consideration many factors such as the clinical presentation, age at diagnosis, rate of disease progression, and systemic and local factors which may increase risk (Pihlstrom BL etal., 2005).
Tissue destruction in periodontitis results in the breakdown of the collagen fibers of the periodontal ligament, that results in the formation of a periodontal pocket between the gingiva and the tooth. "Pocketing" is not evident on simple visual inspection, and assessment using a periodontal probe is needed. Periodontitis is a slowly progressing disease, however the tissue destruction that happens is largely irreversible. The condition is asymptomatic in the early stages, it is not usually painful, and many patients are unaware till progression in the condition occurs and is enough to result in tooth mobility. As a result of the further destruction of fibers of the periodontal ligament (referred to as attachment loss), the pockets deepen, and the resorption of the alveolar bone occurs in parallel with the progressing attachment loss (Grossi SG etal., 1995).
Diabetes mellitus is a metabolic disorder which is characterized by hyperglycemia as a result of defective secretion or activity of insulin (Tan M etal., 1997). It may be further complicated by poor regulation of protein and lipid metabolism. In the current classification of this condition, the terms "insulin-dependent diabetes mellitus" and "non-insulin dependent diabetes mellitus" are not used, in part because they relate to treatment rather than to the diagnosis. A conclusive diagnosis of diabetes mellitus is done through assessment of glycated hemoglobin levels. In those people with diabetes, sequential fasting plasma glucose levels will be 7 mmol/L or more.
Type 1 diabetes mellitus normally occurs as a result of destruction of the beta cells in the islets of Langerhans of the pancreas by the autoimmune system. This condition often leads to absolute deficiency of insulin. Type 1 diabetes tends to occur in young, lean individuals, usually before 30 years of age; however, older patients may also present with this form of diabetes occasionaly.
With Type 2 diabetes, patients can still produce insulin but do so relatively inadequately. In many cases, the pancreas produces larger than normal quantities of insulin. A major feature of Type 2 diabetes is a lack of sensitivity to insulin by the cells of the body, especially fat and muscle cells. These larger quantities of insulin are produced as an attempt to get these cells to recognize that insulin is present.
There is emerging evidence to support the existence of a two-way relationship between diabetes and periodontitis, with diabetes increasing the risk for periodontitis, and periodontal inflammation negatively affecting glycemic control (Fox CH., 1992) & (Mealey BL & Ocampo GL, 2007).
연구 유형
등록 (예상)
연락처 및 위치
연구 연락처
- 이름: Mahmoud R Reda, BDS
- 전화번호: +201002741736
- 이메일: mahmoud.refaiy@dentistry.cu.edu.eg
연구 연락처 백업
- 이름: Weam A Ahmed, Professor
- 전화번호: +201283226072
- 이메일: weamrashwan@dentistry.cu.edu.eg
연구 장소
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Cairo, 이집트
- Faculty of Dentistry Cairo University
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연락하다:
- 전화번호: (+202) 23634965
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
샘플링 방법
연구 인구
설명
Inclusion Criteria:
- Diabetic patients whether Type 1 or 2
- Patient consulting in the outpatient clinic
- Provide informed consent.
Exclusion Criteria:
- Participants who had <10 teeth currently or
- Those who had undergone any periodontal treatment within the past 1 year
- Patients suffering from any other metabolic or systemic diseses tht could affect the periodontal condition
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
---|---|---|
: Prevalence of Periodontitis in diabetics of Egyptian outpatients of faculty of dentistry cairo university.
기간: Baseline
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periodontal charting will be done for diabetic patients attending outpatient clinics
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Baseline
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공동 작업자 및 조사자
스폰서
수사관
- 수석 연구원: Mahmoud R Reda, BDS, Cairo University
연구 기록 날짜
연구 주요 날짜
연구 시작 (예상)
기본 완료 (예상)
연구 완료 (예상)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
periodontal charting only에 대한 임상 시험
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