Office probing for treatment of nasolacrimal duct obstruction in infants
Aaron M Miller, Danielle L Chandler, Michael X Repka, Darren L Hoover, Katherine A Lee, Michele Melia, Paul J Rychwalski, David I Silbert, Pediatric Eye Disease Investigator Group, Roy W Beck, Eric R Crouch 3rd, Sean Donahue, Jonathan M Holmes, Graham E Quinn, Nick A Sala, Susan Schloff, David K Wallace, Nicole C Foster, Kevin D Frick, Richard P Golden, Scott R Lambert, D Robbins Tien, David R Weakley Jr, Nicholas A Sala, Sean Donahue, David G Morrison, Darren L Hoover, Katherine A Lee, Earl R Crouch Jr, Eric R Crouch 3rd, Deborah L Klimek, David R Weakley Jr, Kamel M Itani, Susan Schloff, Ann Marie Hickson, Don L Bremer, Cybil M Bean, Richard P Golden, Mary Lou McGregor, Gary L Rogers, David Robbins Tien, Robert W Arnold, Todd A Goldblum, Benjamin H Ticho, Alexander J Khammar, Deborah R Fishman, Lisa C Verderber, David I Silbert, Don D Blackburn, Troy J Hosey, Eric L Singman, Dave H Lee, Nieca D Caltrider, Scott Atkinson, Evelyn A Paysse, David K Coats, Jane Covington Edmond, Paul G Steinkuller, Kimberly G Yen, Andrew J Levada, Jonathan E Silbert, William F Astle, Michael E Ashenhurst, Anna L Ells, Vivian E Hill, Femida Kherani, Kenneth G Romanchuk, Donny W Suh, David R Stager Sr, David R Stager Jr, Darron A Bacal, Brian J Forbes, James A Katowitz, Graham E Quinn, Lucas Trigler, R Michael Siatkowski, James B Ruben, Oscar A Cruz, Bradley V Davitt, Joan Therese Roberts, C Gail Summers, Erick D Bothun, Stephen P Christiansen, Matthew D Gearinger, Mary Louise Z Collins, Bernard D Perla, Scott R Lambert, Amy K Hutchinson, Erika M Levin, Monte A Del Monte, Maya Eibschitz-Tsimhoni, Rebecca Sands Braverman, Theodore H Curtis, Arlene V Drack, Michael John Bartiss, David T Wheeler, John D Ng, Ann U Stout, Michael X Repka, Maya Eibschitz-Tsimhoni, Erika M Levin, Patrick J Droste, Robert J Peters, Yasmin S Bradfield, Thomas D France, Jonathan M Holmes, Brian G Mohney, Stephen R Glaser, Allison A Jensen, John P Donahue, Nicholas A Sala, Rhonda M Hodde, Veda L Zeto, Katherine A Lee, Bonita R Schweinler, Larry W Plum, David B Petersen, J Ryan McMurtrey, David Robbins Tien, Gi H Yoon-Huang, Myra B McGuinness, Jessica M De La Rosa, Colleen M Bailey, Jo Ann Marinaro, Benjamin H Ticho, Alexander J Khammar, Deborah A Clausius, James B Coletta, Barbara C Imler, Don L Bremer, Cybil M Cassady, Richard P Golden, Mary Lou McGregor, David L Rogers, Gary L Rogers, Rae R Fellows, Meghan C McMillin, Teresa M Rinehart, Amy J Wagner, Jenny A Brendez, Rich E Cox, David R Weakley Jr, Clare L Dias, Xiaowei W Zhang, Earl R Crouch, Eric R Crouch, Gaylord G Ventura, David G Morrison, Lisa A Fraine, Ronald J Biernacki, Christine C Franklin, Kelsie J Haskins, Darren L Hoover, Pamela A Huston, Scott R Lambert, Amy K Hutchinson, Phoebe D Lenhart, Marla J Shainberg, Rachel A Robb, Natario L Couser, Christie L Morse, Caroline C Fang, Melanie L Christian, Virginia X Karlsson, Elias Traboulsi, Paul J Rychwalski, Susan W Crowe, David I Silbert, Eric L Singman, Noelle S Matta, Garry L Leckemby, Michael R Pavlica, C Gail Summers, Erick D Bothun, Inge De Becker, Ann M Holleschau, Anna I de Melo, Kathy M Hogue, Kim S Merrill, Aaron M Miller, Jorie L Jackson, Suzanne S LaRiviere, Todd A Goldblum, Angela Alfaro, Scott Atkinson, Crystal L Trythall, Angela B Hendrickson, John M Avallone, Charlene R Bryant, Wanda E Peyton, Faruk H Orge, Sara E Schoeck, Beth J Colon, Nina X Mar, Reena S Vaswani, Oren L Weisberg, Shannon M Giansanti, Julie M Kaddy, Raymond T Kraker, Roy W Beck, Christina M Cagnina-Morales, Danielle L Chandler, Laura E Clark, Chelsea Costa, Elise R Diamond, Quayleen Donahue, Brooke P Fimbel, Nicole C Foster, Elizabeth L Lazar, Stephanie V Lee, Lee Anne Lester, B Michele Melia, Pamela S Moke, Diana E Rojas, Donald F Everett, Michael X Repka, Katherine A Lee, Jonathan M Holmes, Danielle L Chandler, Kevin Frick, David I Silbert, Nicholas A Sala, Darren L Hoover, Roy W Beck, Katherine A Lee, Michael X Repka, Jonathan M Holmes, Danielle L Chandler, Donald F Everett, Veda L Zeto, Rae R Fellows, Jonathan M Holmes, Roy W Beck, Eileen E Birch, Donald F Everett, Raymond T Kraker, Michael X Repka, Susan A Cotter, David K Wallace, David B Petersen, Laura Enyedi, Darren L Hoover, David L Rogers, Aaron M Miller, Jorie L Jackson, Marjean T Kulp, Benjamin H Ticho, Eric R Crouch 3rd, Darron Bacal, Robert Rutstein, Stephen Christiansen, Pamela Huston, Katherine A Lee, Noelle S Matta, David Morrison, Mitchell Scheiman, Marie Diener-West, John D Baker, Barry Davis, Velma Dobson, Donald F Everett, Dale L Phelps, Stephen Poff, Richard A Saunders, Lawrence Tychsen, Aaron M Miller, Danielle L Chandler, Michael X Repka, Darren L Hoover, Katherine A Lee, Michele Melia, Paul J Rychwalski, David I Silbert, Pediatric Eye Disease Investigator Group, Roy W Beck, Eric R Crouch 3rd, Sean Donahue, Jonathan M Holmes, Graham E Quinn, Nick A Sala, Susan Schloff, David K Wallace, Nicole C Foster, Kevin D Frick, Richard P Golden, Scott R Lambert, D Robbins Tien, David R Weakley Jr, Nicholas A Sala, Sean Donahue, David G Morrison, Darren L Hoover, Katherine A Lee, Earl R Crouch Jr, Eric R Crouch 3rd, Deborah L Klimek, David R Weakley Jr, Kamel M Itani, Susan Schloff, Ann Marie Hickson, Don L Bremer, Cybil M Bean, Richard P Golden, Mary Lou McGregor, Gary L Rogers, David Robbins Tien, Robert W Arnold, Todd A Goldblum, Benjamin H Ticho, Alexander J Khammar, Deborah R Fishman, Lisa C Verderber, David I Silbert, Don D Blackburn, Troy J Hosey, Eric L Singman, Dave H Lee, Nieca D Caltrider, Scott Atkinson, Evelyn A Paysse, David K Coats, Jane Covington Edmond, Paul G Steinkuller, Kimberly G Yen, Andrew J Levada, Jonathan E Silbert, William F Astle, Michael E Ashenhurst, Anna L Ells, Vivian E Hill, Femida Kherani, Kenneth G Romanchuk, Donny W Suh, David R Stager Sr, David R Stager Jr, Darron A Bacal, Brian J Forbes, James A Katowitz, Graham E Quinn, Lucas Trigler, R Michael Siatkowski, James B Ruben, Oscar A Cruz, Bradley V Davitt, Joan Therese Roberts, C Gail Summers, Erick D Bothun, Stephen P Christiansen, Matthew D Gearinger, Mary Louise Z Collins, Bernard D Perla, Scott R Lambert, Amy K Hutchinson, Erika M Levin, Monte A Del Monte, Maya Eibschitz-Tsimhoni, Rebecca Sands Braverman, Theodore H Curtis, Arlene V Drack, Michael John Bartiss, David T Wheeler, John D Ng, Ann U Stout, Michael X Repka, Maya Eibschitz-Tsimhoni, Erika M Levin, Patrick J Droste, Robert J Peters, Yasmin S Bradfield, Thomas D France, Jonathan M Holmes, Brian G Mohney, Stephen R Glaser, Allison A Jensen, John P Donahue, Nicholas A Sala, Rhonda M Hodde, Veda L Zeto, Katherine A Lee, Bonita R Schweinler, Larry W Plum, David B Petersen, J Ryan McMurtrey, David Robbins Tien, Gi H Yoon-Huang, Myra B McGuinness, Jessica M De La Rosa, Colleen M Bailey, Jo Ann Marinaro, Benjamin H Ticho, Alexander J Khammar, Deborah A Clausius, James B Coletta, Barbara C Imler, Don L Bremer, Cybil M Cassady, Richard P Golden, Mary Lou McGregor, David L Rogers, Gary L Rogers, Rae R Fellows, Meghan C McMillin, Teresa M Rinehart, Amy J Wagner, Jenny A Brendez, Rich E Cox, David R Weakley Jr, Clare L Dias, Xiaowei W Zhang, Earl R Crouch, Eric R Crouch, Gaylord G Ventura, David G Morrison, Lisa A Fraine, Ronald J Biernacki, Christine C Franklin, Kelsie J Haskins, Darren L Hoover, Pamela A Huston, Scott R Lambert, Amy K Hutchinson, Phoebe D Lenhart, Marla J Shainberg, Rachel A Robb, Natario L Couser, Christie L Morse, Caroline C Fang, Melanie L Christian, Virginia X Karlsson, Elias Traboulsi, Paul J Rychwalski, Susan W Crowe, David I Silbert, Eric L Singman, Noelle S Matta, Garry L Leckemby, Michael R Pavlica, C Gail Summers, Erick D Bothun, Inge De Becker, Ann M Holleschau, Anna I de Melo, Kathy M Hogue, Kim S Merrill, Aaron M Miller, Jorie L Jackson, Suzanne S LaRiviere, Todd A Goldblum, Angela Alfaro, Scott Atkinson, Crystal L Trythall, Angela B Hendrickson, John M Avallone, Charlene R Bryant, Wanda E Peyton, Faruk H Orge, Sara E Schoeck, Beth J Colon, Nina X Mar, Reena S Vaswani, Oren L Weisberg, Shannon M Giansanti, Julie M Kaddy, Raymond T Kraker, Roy W Beck, Christina M Cagnina-Morales, Danielle L Chandler, Laura E Clark, Chelsea Costa, Elise R Diamond, Quayleen Donahue, Brooke P Fimbel, Nicole C Foster, Elizabeth L Lazar, Stephanie V Lee, Lee Anne Lester, B Michele Melia, Pamela S Moke, Diana E Rojas, Donald F Everett, Michael X Repka, Katherine A Lee, Jonathan M Holmes, Danielle L Chandler, Kevin Frick, David I Silbert, Nicholas A Sala, Darren L Hoover, Roy W Beck, Katherine A Lee, Michael X Repka, Jonathan M Holmes, Danielle L Chandler, Donald F Everett, Veda L Zeto, Rae R Fellows, Jonathan M Holmes, Roy W Beck, Eileen E Birch, Donald F Everett, Raymond T Kraker, Michael X Repka, Susan A Cotter, David K Wallace, David B Petersen, Laura Enyedi, Darren L Hoover, David L Rogers, Aaron M Miller, Jorie L Jackson, Marjean T Kulp, Benjamin H Ticho, Eric R Crouch 3rd, Darron Bacal, Robert Rutstein, Stephen Christiansen, Pamela Huston, Katherine A Lee, Noelle S Matta, David Morrison, Mitchell Scheiman, Marie Diener-West, John D Baker, Barry Davis, Velma Dobson, Donald F Everett, Dale L Phelps, Stephen Poff, Richard A Saunders, Lawrence Tychsen
Abstract
Purpose: To determine whether demographic or clinical factors are associated with the outcome of office-based nasolacrimal duct probing for the treatment of congenital nasolacrimal duct obstruction (NLDO).
Methods: In two multicenter prospective studies, 384 eyes of 304 children aged 6 to <15 months with NLDO underwent a nasolacrimal duct probing performed in the office using topical anesthesia. Treatment success, defined as no clinical signs of NLDO (epiphora, increased tear lake, or mucous discharge) and no reoperation, was assessed 1 month after probing in one study and 6 months after probing in the other study. Data from both studies were pooled to evaluate associations between baseline characteristics and treatment success.
Results: Office probing was successful in 75% of eyes overall (95% CI, 70%-80%). The procedure was less successful in eyes of children with bilateral NLDO compared with unilateral NLDO (63% vs 80%; relative risk = 0.78 [95% CI, 0.66-0.92]) and in eyes that had 2 or 3 clinical signs of NLDO compared with one (71% vs 83%; relative risk = 0.88 [95% CI, 0.81-0.96]). Treatment success did not appear to be related to age, specific clinical signs of NLDO, prior treatment, or research study.
Conclusions: Performing nasolacrimal duct probing in the office successfully treats NLDO in the majority of cases in children aged 6 to <15 months. The success rate is lower with bilateral disease or when more than one clinical sign of NLDO is present.
Trial registration: ClinicalTrials.gov NCT00315289 NCT00780741.
Copyright © 2014 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved.
Source: PubMed