Comparative Study of Arterial Properties After an Ischaemic Stroke or an Acute Coronary Syndrome (AVC/SCA)
A Comparative Study of Structural and Functional Arterial Properties After an Ischaemic Stroke or an Acute Coronary Syndrome
A pilot, prospective, comparative study. To include both male and female patients who have presented an ischaemic stroke (full stroke or TIA) or an ACS, 5 to 30 days prior to inclusion.
The proposed study aims to investigate and analyse the differences in functional and structural arterial properties between the patients who presented an ischaemic stroke and those who presented ACS. The hypothesis is that the patients in both groups will present differences partly in terms of their "traditional" cardiovascular risk factors, but also in terms of their arterial properties. All of the confounding factors studied (cardiovascular risk factors, treatments) will be taken into account in order to explain the differences in the arterial properties found between the two groups. Furthermore, the prevalence of signs and symptoms in the two populations will be studied.
調査の概要
状態
詳細な説明
A comparative study of structural and functional arterial properties after an ischaemic stroke or an acute coronary syndrome
Objectives:
Primary:
- To determine whether there is a difference in the biomechanical properties of the carotid arteries, assessed by studying their stiffness, after an acute vascular event, depending on whether the event is an ischaemic stroke (either a full stroke or a transitory ischaemic attack (TIA)) or an acute coronary syndrome (ACS).
Secondary:
- To determine whether there is a difference in aortic stiffness and brachial endothelial function after an acute vascular event, depending on whether the event is an ischaemic stroke (full stroke or TIA) or an ACS.
- To compare the blood pressure (BP) levels and the vascular parameters of the two patient groups (the ischaemic stroke group and the ACS group).
- To determine whether there is a difference between the respiratory parameters recorded during sleep after an acute vascular event, depending on whether the event is an ischaemic stroke (full stroke or TIA) or an ACS.
研究の種類
入学 (予想される)
連絡先と場所
研究場所
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Grenoble、フランス
- 募集
- University Hospital
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コンタクト：
- Baguet Jean-Philippe, Professor
- 電話番号：0033476768480
- メール：JPBaguet@chu-grenoble.fr
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Male and female patients
- Between 40 and 70 years of age
- Who have given their written consent
- Who have presented the following between 5 and 30 days prior to inclusion:
- either an ischaemic stroke (full stroke or TIA) that has been stabilised from a neurological point of view, with no haemorrhage but with direct signs of ischaemia on the cerebral imaging (computed tomography or MRI), diagnosed during patient questioning and/or the clinical examination;
- or an ACS that has been stabilised from a cardiological point of view, with troponin elevation in at least 2 samples and/or ECG changes that indicate acute myocardial ischaemia, diagnosed during patient questioning.
- Who are affiliated to the French social security system
Exclusion Criteria:
For patients included in the ACS group
- Stroke less than 6 months ago
- Coronary bypass between the start of their hospitalisation for ACS and inclusion
For patients included in the stroke group
- Emboligenic heart disease
- ACS less than 6 months ago
For all patients
- Atrial fibrillation or flutter, or frequent extrasystole (more than 10/minute) upon inclusion
- History of surgery or carotid stenting
- Very reduced mobility meaning that they cannot remain standing without assistance or without using a walking stick
研究計画
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
|---|
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1
patients who presented an ischaemic stroke(full stroke or TIA)
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2
patients who present an acute coronary syndrome (ACS).
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
時間枠 |
|---|---|
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biomechanical properties of the carotid arteries
時間枠：1-6 months
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1-6 months
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二次結果の測定
結果測定 |
時間枠 |
|---|---|
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aortic stiffness and brachial endothelial function
時間枠：1-6 months
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1-6 months
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blood pressure (BP) levels and the vascular parameters
時間枠：1-6 months
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1-6 months
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respiratory parameters recorded during sleep
時間枠：1-6 months
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1-6 months
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協力者と研究者
捜査官
- 主任研究者：BAGUET Jean Philippe, Professor、University Hospital, Grenoble
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始
一次修了 (予想される)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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