Comparative Study of Arterial Properties After an Ischaemic Stroke or an Acute Coronary Syndrome (AVC/SCA)
A Comparative Study of Structural and Functional Arterial Properties After an Ischaemic Stroke or an Acute Coronary Syndrome
A pilot, prospective, comparative study. To include both male and female patients who have presented an ischaemic stroke (full stroke or TIA) or an ACS, 5 to 30 days prior to inclusion.
The proposed study aims to investigate and analyse the differences in functional and structural arterial properties between the patients who presented an ischaemic stroke and those who presented ACS. The hypothesis is that the patients in both groups will present differences partly in terms of their "traditional" cardiovascular risk factors, but also in terms of their arterial properties. All of the confounding factors studied (cardiovascular risk factors, treatments) will be taken into account in order to explain the differences in the arterial properties found between the two groups. Furthermore, the prevalence of signs and symptoms in the two populations will be studied.
研究概览
地位
详细说明
A comparative study of structural and functional arterial properties after an ischaemic stroke or an acute coronary syndrome
Objectives:
Primary:
- To determine whether there is a difference in the biomechanical properties of the carotid arteries, assessed by studying their stiffness, after an acute vascular event, depending on whether the event is an ischaemic stroke (either a full stroke or a transitory ischaemic attack (TIA)) or an acute coronary syndrome (ACS).
Secondary:
- To determine whether there is a difference in aortic stiffness and brachial endothelial function after an acute vascular event, depending on whether the event is an ischaemic stroke (full stroke or TIA) or an ACS.
- To compare the blood pressure (BP) levels and the vascular parameters of the two patient groups (the ischaemic stroke group and the ACS group).
- To determine whether there is a difference between the respiratory parameters recorded during sleep after an acute vascular event, depending on whether the event is an ischaemic stroke (full stroke or TIA) or an ACS.
研究类型
注册 (预期的)
联系人和位置
学习地点
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Grenoble、法国
- 招聘中
- University Hospital
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接触：
- Baguet Jean-Philippe, Professor
- 电话号码：0033476768480
- 邮箱：JPBaguet@chu-grenoble.fr
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Male and female patients
- Between 40 and 70 years of age
- Who have given their written consent
- Who have presented the following between 5 and 30 days prior to inclusion:
- either an ischaemic stroke (full stroke or TIA) that has been stabilised from a neurological point of view, with no haemorrhage but with direct signs of ischaemia on the cerebral imaging (computed tomography or MRI), diagnosed during patient questioning and/or the clinical examination;
- or an ACS that has been stabilised from a cardiological point of view, with troponin elevation in at least 2 samples and/or ECG changes that indicate acute myocardial ischaemia, diagnosed during patient questioning.
- Who are affiliated to the French social security system
Exclusion Criteria:
For patients included in the ACS group
- Stroke less than 6 months ago
- Coronary bypass between the start of their hospitalisation for ACS and inclusion
For patients included in the stroke group
- Emboligenic heart disease
- ACS less than 6 months ago
For all patients
- Atrial fibrillation or flutter, or frequent extrasystole (more than 10/minute) upon inclusion
- History of surgery or carotid stenting
- Very reduced mobility meaning that they cannot remain standing without assistance or without using a walking stick
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
|---|
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1
patients who presented an ischaemic stroke(full stroke or TIA)
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2
patients who present an acute coronary syndrome (ACS).
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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biomechanical properties of the carotid arteries
大体时间：1-6 months
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1-6 months
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次要结果测量
结果测量 |
大体时间 |
|---|---|
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aortic stiffness and brachial endothelial function
大体时间：1-6 months
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1-6 months
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blood pressure (BP) levels and the vascular parameters
大体时间：1-6 months
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1-6 months
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respiratory parameters recorded during sleep
大体时间：1-6 months
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1-6 months
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合作者和调查者
调查人员
- 首席研究员：BAGUET Jean Philippe, Professor、University Hospital, Grenoble
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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