P. Gingivalis IgG Titer Test for Periodontitis
Assessment of Use of Plasma or Serum IgG Test to Screen for Periodontitis
調査の概要
状態
条件
詳細な説明
Background: Periodontitis is a prevalent silent infectious disease worldwide, and affects lifestyle-related diseases such as diabetes. Therefore, efficient screening of patients is essential for general health. This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens.
Methods: Oral examination was performed and blood IgG antibody titers against periodontal pathogens were measured by ELISA, in 1387 subjects. The cut-off value of IgG titer was determined in receiver operating characteristic curve analysis, and changes in periodontal clinical parameters and IgG titers by periodontal treatment were evaluated. The relationships between IgG titers and severity of periodontitis were analyzed.
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Hiroshima、日本、7348553
- Hiroshima University Graduate School of Biomedical Sciences
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Nagasaki、日本、8528588
- Nagasaki University Graduate School of Biomedical Sciences
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Niigata、日本、9518514
- Niigata University Faculty of Dentistry
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Okayama、日本、7008525
- Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Tokushima、日本、7708504
- The University of Tokushima Graduate School, Institute of Health Biosciences
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Aichi
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Nagoya、Aichi、日本、4648650
- Aichi Gakuin University, School of Dentistry
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Toyota、Aichi、日本、4442225
- Toyota Motor Corporation
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Chiba
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Matsudo、Chiba、日本、2718587
- Nihon University School of Dentistry at Matsudo
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Miyagi
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Sendai、Miyagi、日本、9808575
- Tohoku University Graduate School of Dentistry
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Osaka
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Suita、Osaka、日本、5650871
- Osaka University Graduate School of Dentistry
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Tokyo
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Bunkyo-ku、Tokyo、日本、1138510
- Tokyo Medical and Dental University Graduate School
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Chiyoda-ku、Tokyo、日本、1020071
- Nippon Dental University, School of Life Dentistry at Tokyo
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
Patients who visit university hospitals to receive periodontal treatment are patients group.
Employees who receive occupational health check at a company facility.
説明
Inclusion Criteria:
- periodontal patients
- adults
Exclusion Criteria:
- difficulty of communication
- received periodontal therapy within 3 months
- with other diseases, i.e., hypertension, diabetes (self reported)
研究計画
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
|---|
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periodontitis
those with periodontitis and those without periodontitis
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Level of IgG antibodies in serum/plasma against periodontal pathogens
時間枠：1 to 3 months after basic periodontal treatment (Scaling and root planing)
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Serum/plasma samples will be screened for the presence of IgG antibodies against the below mentioned periodontal pathogens, using the "ELISA" method. Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Prevotella intermedius, Porphyromonas gingivalis |
1 to 3 months after basic periodontal treatment (Scaling and root planing)
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Periodontal pocket depth
時間枠：1 to 3 months after basic periodontal treatment
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Clinical observation on periodontal pocket depth before and after basic periodontal treatment, in order to confirm appropriate effects of the treatment.
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1 to 3 months after basic periodontal treatment
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Bleeding on probing
時間枠：1 to 3 monthsafter basic periodontal treatment
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Judging from bleeding from gingiva after periodontal pocket probing, degree of inflammation will be understood.
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1 to 3 monthsafter basic periodontal treatment
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Tooth mobility
時間枠：1 to 3 months after basic periodontal treatment
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Clinical observation to understand decrease of inflammation
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1 to 3 months after basic periodontal treatment
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協力者と研究者
スポンサー
捜査官
- 主任研究者：Shogo Takashiba, Professor、Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Pathiphysiology - Periodontal Science
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。