P. Gingivalis IgG Titer Test for Periodontitis
Assessment of Use of Plasma or Serum IgG Test to Screen for Periodontitis
研究概览
地位
条件
详细说明
Background: Periodontitis is a prevalent silent infectious disease worldwide, and affects lifestyle-related diseases such as diabetes. Therefore, efficient screening of patients is essential for general health. This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens.
Methods: Oral examination was performed and blood IgG antibody titers against periodontal pathogens were measured by ELISA, in 1387 subjects. The cut-off value of IgG titer was determined in receiver operating characteristic curve analysis, and changes in periodontal clinical parameters and IgG titers by periodontal treatment were evaluated. The relationships between IgG titers and severity of periodontitis were analyzed.
研究类型
注册 (实际的)
联系人和位置
学习地点
-
-
-
Hiroshima、日本、7348553
- Hiroshima University Graduate School of Biomedical Sciences
-
Nagasaki、日本、8528588
- Nagasaki University Graduate School of Biomedical Sciences
-
Niigata、日本、9518514
- Niigata University Faculty of Dentistry
-
Okayama、日本、7008525
- Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
-
Tokushima、日本、7708504
- The University of Tokushima Graduate School, Institute of Health Biosciences
-
-
Aichi
-
Nagoya、Aichi、日本、4648650
- Aichi Gakuin University, School of Dentistry
-
Toyota、Aichi、日本、4442225
- Toyota Motor Corporation
-
-
Chiba
-
Matsudo、Chiba、日本、2718587
- Nihon University School of Dentistry at Matsudo
-
-
Miyagi
-
Sendai、Miyagi、日本、9808575
- Tohoku University Graduate School of Dentistry
-
-
Osaka
-
Suita、Osaka、日本、5650871
- Osaka University Graduate School of Dentistry
-
-
Tokyo
-
Bunkyo-ku、Tokyo、日本、1138510
- Tokyo Medical and Dental University Graduate School
-
Chiyoda-ku、Tokyo、日本、1020071
- Nippon Dental University, School of Life Dentistry at Tokyo
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
Patients who visit university hospitals to receive periodontal treatment are patients group.
Employees who receive occupational health check at a company facility.
描述
Inclusion Criteria:
- periodontal patients
- adults
Exclusion Criteria:
- difficulty of communication
- received periodontal therapy within 3 months
- with other diseases, i.e., hypertension, diabetes (self reported)
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
|---|
|
periodontitis
those with periodontitis and those without periodontitis
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Level of IgG antibodies in serum/plasma against periodontal pathogens
大体时间：1 to 3 months after basic periodontal treatment (Scaling and root planing)
|
Serum/plasma samples will be screened for the presence of IgG antibodies against the below mentioned periodontal pathogens, using the "ELISA" method. Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Prevotella intermedius, Porphyromonas gingivalis |
1 to 3 months after basic periodontal treatment (Scaling and root planing)
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Periodontal pocket depth
大体时间：1 to 3 months after basic periodontal treatment
|
Clinical observation on periodontal pocket depth before and after basic periodontal treatment, in order to confirm appropriate effects of the treatment.
|
1 to 3 months after basic periodontal treatment
|
|
Bleeding on probing
大体时间：1 to 3 monthsafter basic periodontal treatment
|
Judging from bleeding from gingiva after periodontal pocket probing, degree of inflammation will be understood.
|
1 to 3 monthsafter basic periodontal treatment
|
|
Tooth mobility
大体时间：1 to 3 months after basic periodontal treatment
|
Clinical observation to understand decrease of inflammation
|
1 to 3 months after basic periodontal treatment
|
合作者和调查者
调查人员
- 首席研究员：Shogo Takashiba, Professor、Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Pathiphysiology - Periodontal Science
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.