うつ病患者の薬物使用を減らすための動機付け面接
2015年6月8日 更新者：University of California, San Francisco
この研究は、うつ病の治療を求めており、うつ病を伴う危険な飲酒や薬物使用も報告している成人300人のサンプルを対象に、アルコールと薬物の使用とうつ病の症状を軽減し、機能状態を改善し、適切な医療サービスの利用を促進するための介入の有効性を評価することを目的としています。 。
調査の概要
詳細な説明
この研究は、精神科でうつ病を悪化させる可能性のあるアルコールや薬物の使用を伴う患者をどのように特定して治療するかに関する重要な疑問に取り組んでいます。
研究者らは、うつ病患者の薬物とアルコールの使用を減らし、必要に応じてカイザー化学物質依存回復プログラム（CDRP）への関与を強化するための、簡単な動機付け介入（BMI）の研究を提案している。
たとえ診断下位のレベルであっても薬物やアルコールを使用するうつ病患者は、薬物問題が悪化するリスクが高くなります。
BMI は、薬物とアルコールの使用を減らし、結果を改善できる革新的な科学的根拠に基づいたアプローチです。
しかし、うつ病患者に対してはテストされていません。
この研究サンプルには、カイザー パーマネンテ北カリフォルニア ヘイワード/フリーモント精神科でうつ病の治療を受けている外来患者 300 人が含まれます。
対象基準は、薬物使用（違法薬物の使用および処方薬の非処方使用）および危険な飲酒（つまり、女性の場合は 1 日あたり 3 杯以上、男性の場合は 1 日あたり 4 杯以上）に基づいており、中等度から重度の場合摂取時のうつ病の症状。
300人の患者は、摂取後6週間以内に1回の対面BMIセッションと2回の電話BMIセッションを受けるか（介入）、または薬物およびアルコール使用のリスクに関するパンフレット（対照）を受けるよう無作為に割り付けられる。
研究者らは、この介入が3、6、12か月後の電話フォローアップ面接で薬物使用と危険な飲酒の頻度を減らすのに効果的であると予想している。気分と機能的成果を改善する。うつ病の治療継続率の増加（医療効果データおよび情報セット（HEDIS）基準に基づく精神科受診回数）。必要に応じて患者の化学物質依存プログラム治療の開始を促進し、費用対効果が高くなります。
患者ケアを改善するために、精神科におけるアルコールと薬物介入の統合や、必要なときに患者が専門の CDRP サービスにアクセスできるようにする最善の方法についての重要な情報も得られます。
研究の種類
介入
入学 (実際)
307
段階
- 適用できない
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究場所
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California
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Union City、California、アメリカ、94545
- Kaiser Permanente Medical Center Southern Alameda County
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参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
18年歳以上 (大人、高齢者)
健康ボランティアの受け入れ
いいえ
受講資格のある性別
全て
説明
包含基準:
- 危険な飲酒（女性の場合は1日あたり3杯以上、男性の場合は1日あたり4杯以上）
- 薬物使用（過去30日間の違法薬物使用および処方薬以外の処方薬の使用を含む）
- 患者健康質問書（PHQ-9）のスコア5以上に基づく中等度以上のうつ病の症状
除外基準:
- 現在の躁状態または精神病
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：ヘルスサービス研究
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：モチベーションを高める面接
動機付け面接 (MI) 介入は、45 分間の対面 MI セッション 1 回と、それに続く 15 分間の電話「ブースター」セッション 2 回で構成されました。
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アクティブコンパレータ：コントロール
参加者はアルコールと薬物使用のリスクに関するパンフレットを受け取りました。
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参加者はアルコールと薬物使用のリスクに関するパンフレットを受け取りました。
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
過去 30 日間の危険な飲酒（危険な飲酒の自己申告日数）
時間枠：6ヵ月
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過去 30 日間の自己申告による危険な飲酒日数 (女性は 1 日あたり 3 杯以上、男性は 1 日あたり 4 杯以上)。
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6ヵ月
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過去30日間の薬物使用（薬物使用日数の自己申告）
時間枠：6ヵ月
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過去 30 日間の薬物使用 (違法薬物使用または処方薬の誤用) の自己申告日数。
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6ヵ月
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過去 30 日間の危険な飲酒（危険な飲酒の自己申告日数）
時間枠：12ヶ月
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過去 30 日間の自己申告による危険な飲酒日数 (女性は 1 日あたり 3 杯以上、男性は 1 日あたり 4 杯以上)。
長期介入の影響を測定するために、6 か月後の使用と 12 か月後の使用の間の変化を調べます。
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12ヶ月
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過去30日間の薬物使用（薬物使用日数の自己申告）
時間枠：12ヶ月
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過去 30 日間の薬物使用 (違法薬物使用または処方薬の誤用) の自己申告日数。
長期介入の影響を測定するために、6 か月から 12 か月の間の使用量の変化を調べます。
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12ヶ月
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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うつ病の症状（患者健康質問票（PHQ-9）スコア）
時間枠：12ヶ月
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PHQ-9 は、過去 2 週間における 9 種類の問題の頻度を評価します。回答の範囲は 0 (まったくない) から 3 (ほぼ毎日) です。
9 つのうち少なくとも 4 つが >0 の場合、項目スコアの合計を使用してうつ病の重症度が示されます。1 ～ 4 最小。 5-9 軽度。 10-14 中程度。 15-19 中程度に重度。 20-27 深刻。
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12ヶ月
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適切なメンタルヘルス治療（カイザー・パーマネンテ精神科外来で12週間継続して治療を受けた参加者数）
時間枠：3ヶ月
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カイザー・パーマネンテ精神科外来で12週間の継続治療を受けた参加者の数
|
3ヶ月
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協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
捜査官
- 主任研究者：Derek D Satre, PhD、University of California, San Francisco
出版物と役立つリンク
研究に関する情報を入力する責任者は、自発的にこれらの出版物を提供します。これらは、研究に関連するあらゆるものに関するものである可能性があります。
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研究記録日
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主要日程の研究
研究開始
2010年10月1日
一次修了 (実際)
2014年8月1日
研究の完了 (実際)
2014年8月1日
試験登録日
最初に提出
2015年4月7日
QC基準を満たした最初の提出物
2015年4月17日
最初の投稿 (見積もり)
2015年4月20日
学習記録の更新
投稿された最後の更新 (見積もり)
2015年6月10日
QC基準を満たした最後の更新が送信されました
2015年6月8日
最終確認日
2015年6月1日
詳しくは
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