Acute Effects of Watermelon on Vascular Function and Serum Lycopene
調査の概要
詳細な説明
Purpose and Objectives Arterial stiffness and endothelial dysfunction are early independent predictors of cardiovascular disease (CVD), the leading cause of death for women ages 60 and older in the United States. It is well-known that age-related decreases in vascular function are partially due to increases in oxidative stress and inflammation. In attempts to combat CVD, previous studies have investigated provision of isolated food compounds in supplement form. For example, purified lycopene has been shown to decrease oxidative stress, and our previous work supports the supplemental use of glutamine and arginine powders for improving vascular endothelial function of older adults. Watermelon is among the greatest plant sources of arginine and glutamine, and it is one of the richest sources of lycopene. However, clinical studies evaluating the whole food have not been done.
According to the Healthy Eating Index, only 27% of women ages 60 and older meet the daily dietary recommendations for 2.5 fruit servings. Likewise, although no Recommended Dietary Allowance for lycopene exists, this age group consumes less lycopene daily than is provided in one serving of watermelon. While reasons for poor fruit intake among older adults are multifactorial, difficulty chewing and inability to prepare fresh foods in the home environment have been noted as significant barriers to fresh fruit and vegetable intake. Of note, a previous systematic review suggests that 100% fruit and vegetable juices may be practical vehicles for improving intake of antioxidant nutrients among older adults. The provision of 100% watermelon juice to older adult women represents a practical, innovative approach to increase consumption of a food containing multiple components that may act in synergy to improve vascular function. Therefore, the purpose of this study is to investigate the effects of a one-time serving of 100% watermelon juice on blood vessel function and serum lycopene.
Specific Aims
The specific aims of this study are to:
To determine whether consumption of a 12-ounce serving of 100% watermelon juice by non-obese women ages 60-75 will result in increased levels of serum lycopene.
Hypotheses: Acute supplementation with 100% watermelon juice will result in increased serum lycopene.
- To determine whether consumption of a 12-ounce serving of 100% watermelon juice by non-obese women ages 60-75 will result in improved vascular endothelial function as assessed by flow-mediated dilation (FMD) and decreased arterial stiffness as assessed by pulse wave analysis (PWA).
Hypotheses: Acute supplementation with 100% watermelon juice will result in improved vascular endothelial function and decreased arterial stiffness.
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Alabama
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Tuscaloosa、Alabama、アメリカ、35487
- University of Alabama
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Body mass index 18.5 - 29.9 kg/m2 (non-obese)
- Ambulatory
- Postmenopausal female
- Ages 65-70 years
Exclusion Criteria:
- Food allergy to watermelon
- Diagnosis of phenylketonuria
- History of hypotension, chronic uncontrolled hypertension, chronic kidney disease, diabetes, previous cardiac events or procedures,
- Smoking or other tobacco use
- Use of anticoagulant medications, cholesterol-lowering medications, vasodilatory dietary supplements (garlic, fish oil), or dietary supplements containing lycopene, ascorbic acid, L-glutamine, L-arginine, or L-citrulline
- Weight change > 10% in the previous six months
研究計画
研究はどのように設計されていますか?
デザインの詳細
この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
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Change From Baseline in Circulating Lycopene Levels
時間枠:2 hours post-ingestion
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On the testing day, participants reported to the clinic following a 10-hour overnight fast.
Blood samples were obtained by standard venipuncture at baseline and two hours after ingestion of a 360 ml dose of 100% pasteurized watermelon juice in order to determine change in serum lycopene levels.
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2 hours post-ingestion
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
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Change From Baseline in Endothelial-dependent Vasodilation
時間枠:2 hours post-ingestion
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Brachial artery flow-mediated dilation (FMD) was used to assess endothelial-dependent vasodilation.
FMD uses ultrasound technology to quantify changes in brachial artery diameter in response to hyperemia.
A blood pressure cuff was placed distal to the brachial artery of the right arm with the participant supine and rested.
Pre-inflation diameter was recorded for one minute, and the cuff was inflated to 50 mmHg above resting SBP for five minutes.
Then, images were recorded for 120 seconds after cuff deflation.
Peak diameter was determined as an average of the five highest measurements over five seconds post-deflation.
FMD was expressed as the percentage increase in peak diameter.
FMD measurements were taken at baseline and 2 hours after ingestion of the 100% watermelon juice.
The outcome measure reflects change in FMD from baseline to 2 hours post-ingestion.
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2 hours post-ingestion
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研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- 15-07-95
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
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Vascular Health of Postmenopausal Womenの臨床試験
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Queens College, The City University of New York募集American Journal of Public Healthに投稿された論文の出版アメリカ
100% watermelon juiceの臨床試験
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Sumitomo Pharma America, Inc.BehaVR LLC完了