Individualized Versus Non-Individualized Resistance Training
加齢に伴う筋力と機能的能力の低下を防ぐためのオーダーメイドの介入
Preserving functional ability is crucial for healthy aging. Unfortunately, age-related decreases in muscle power often lead to declines in functional ability. As power is the product of force and velocity, decreases in power can originate from changes in muscle force, contraction velocity, or both, varying between individuals. The primary method to prevent functional disability is power-based resistance training. Although training interventions are effective for most older adults, they do not induce substantial improvements in a subset of the population. These inconsistent outcomes may arise from neglecting the observed differences in the force-velocity (F-V) profiles between individuals. Therefore, this study provides a novel approach to resistance exercise, in which exercise dose is tailored according to the individual's F-V profile. The effectiveness of the tailored method will be assessed in a randomized control trial, comparing the effects of an individualized and a non-individualized 12-week training intervention on muscle power parameters and functional ability.
調査の概要
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
-
-
Vlaams-Brabant
-
Leuven、Vlaams-Brabant、ベルギー、3000
- KU Leuven - Department of Movement Sciences
-
-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Community-dwelling adults
- At least 65 years old
Exclusion Criteria:
- Systematic engagement in resistance exercise during the past year
- Unstable cardiovascular disease, neuromuscular disease, acute infection or fever
- Recent surgery
- Lower-extremity injuries
- Low levels of functional ability (i.e., SPPB score ≤ 9)
- Cognitive malfunctioning (i.e., Mini-Mental State Examination < 24)
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：防止
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
実験的：Individualized resistance exercise program
Individualized exercise dose. All individuals perform resistance exercises at a load that targets their deficit. Individuals with a velocity deficit train at low loads while individuals with a force deficit train at high loads. |
2x/week, 35-45 min sessions, on leg press machine |
|
アクティブコンパレータ：Non-individualized resistance exercise program
Non-individualized exercise dose. All individuals perform resistance exercises at a load that does not target their deficit. Individuals with a velocity deficit train at high loads while individuals with a force deficit train at low loads. |
2x/week, 35-45 min sessions, on leg press machine |
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Maximal power (Pmax)
時間枠：Change from baseline at 6 and 12 weeks
|
Participants performed explosive unilateral leg extensions with the dominant leg at five submaximal loads on a pneumatic leg press (Leg Press Air 400, Keiser, USA). Submaximal loads were scaled to the estimated maximal isometric force derived from the familiarization session. The three lighter loads were performed three times each and the two heavier loads twice, with the repetition yielding the highest mean concentric velocity retained for analysis. Participants subsequently performed single repetitions at incrementally increasing loads until 1-RM was reached. Rest intervals were adjusted according to the load of the preceding trial: 60 s after the three lightest loads, 90 s after the two heavier loads, and 120 s during the incremental trials leading to 1-RM. For each load, the mean concentric velocity of the best trial was used to establish the individual force-velocity (F-V) relationship using linear regression, from which the maximal power (Pmax; W) was estimated. |
Change from baseline at 6 and 12 weeks
|
|
Maximal isometric force (F0)
時間枠：Change from baseline at 6 and 12 weeks
|
Participants performed explosive unilateral leg extensions with the dominant leg at five submaximal loads on a pneumatic leg press (Leg Press Air 400, Keiser, USA). Submaximal loads were scaled to the estimated maximal isometric force derived from the familiarization session. The three lighter loads were performed three times each and the two heavier loads twice, with the repetition yielding the highest mean concentric velocity retained for analysis. Participants subsequently performed single repetitions at incrementally increasing loads until 1-RM was reached. Rest intervals were adjusted according to the load of the preceding trial: 60 s after the three lightest loads, 90 s after the two heavier loads, and 120 s during the incremental trials leading to 1-RM. For each load, the mean concentric velocity of the best trial was used to establish the individual force-velocity (F-V) relationship using linear regression, from which maximal isometric force (F0; N) was estimated. |
Change from baseline at 6 and 12 weeks
|
|
Maximal unloaded velocity (V0)
時間枠：Change from baseline at 6 and 12 weeks
|
Participants performed explosive unilateral leg extensions with the dominant leg at five submaximal loads on a pneumatic leg press (Leg Press Air 400, Keiser, USA). Submaximal loads were scaled to the estimated maximal isometric force derived from the familiarization session. The three lighter loads were performed three times each and the two heavier loads twice, with the repetition yielding the highest mean concentric velocity retained for analysis. Participants subsequently performed single repetitions at incrementally increasing loads until 1-RM was reached. Rest intervals were adjusted according to the load of the preceding trial: 60 s after the three lightest loads, 90 s after the two heavier loads, and 120 s during the incremental trials leading to 1-RM. For each load, the mean concentric velocity of the best trial was used to establish the individual force-velocity (F-V) relationship using linear regression, from which maximal unloaded velocity (V0; m/s) was estimated. |
Change from baseline at 6 and 12 weeks
|
|
Force-velocity slope
時間枠：Change from baseline at 6 and 12 weeks
|
Participants performed explosive unilateral leg extensions with the dominant leg at five submaximal loads on a pneumatic leg press (Leg Press Air 400, Keiser, USA). Submaximal loads were scaled to the estimated maximal isometric force derived from the familiarization session. The three lighter loads were performed three times each and the two heavier loads twice, with the repetition yielding the highest mean concentric velocity retained for analysis. Participants subsequently performed single repetitions at incrementally increasing loads until 1-RM was reached. Rest intervals were adjusted according to the load of the preceding trial: 60 s after the three lightest loads, 90 s after the two heavier loads, and 120 s during the incremental trials leading to 1-RM. For each load, the mean concentric velocity of the best trial was used to establish the individual force-velocity (F-V) relationship using linear regression, from which the F-V slope (Ns/m) was derived. |
Change from baseline at 6 and 12 weeks
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Short Physical Performance Battery (SPPB)
時間枠：Score at baseline
|
Total score on the SPPB (min 0, max 12, higher scores indicate better performance) |
Score at baseline
|
|
Hand grip strength
時間枠：Change from baseline at 6 and 12 weeks
|
Maximal grip strength (kg) of the dominant hand using an isometric dynamometer adjusted for hand size |
Change from baseline at 6 and 12 weeks
|
|
Maximal gait speed
時間枠：Change from baseline at 6 and 12 weeks
|
The average time (s) to walk 10m as fast as possible |
Change from baseline at 6 and 12 weeks
|
|
Countermovement jump
時間枠：Change from baseline at 6 and 12 weeks
|
The jump height (mm) in a countermovement jump |
Change from baseline at 6 and 12 weeks
|
|
Timed up-and-go
時間枠：Change from baseline at 6 and 12 weeks
|
The time (s) needed to stand up from a chair, walk 3 m, turn, walk back and sit down again as fast as possible |
Change from baseline at 6 and 12 weeks
|
|
5-repetition sit-to-stand time
時間枠：Change from baseline at 6 and 12 weeks
|
The time (s) needed to complete the 5-repetition sit-to-stand test |
Change from baseline at 6 and 12 weeks
|
|
5-repetition sit-to-stand power
時間枠：Change from baseline at 6 and 12 weeks
|
The average power (watt) produced during the 5-repetition sit-to-stand test |
Change from baseline at 6 and 12 weeks
|
|
30-second sit-to-stand repetitions
時間枠：Change from baseline at 6 and 12 weeks
|
The number of repetitions completed during the 30-second sit-to-stand test |
Change from baseline at 6 and 12 weeks
|
|
30-second sit-to-stand power
時間枠：Change from baseline at 6 and 12 weeks
|
The average power (watt) produced during the 30-second sit-to-stand test |
Change from baseline at 6 and 12 weeks
|
|
Stair ascent time
時間枠：Change from baseline at 6 and 12 weeks
|
The time (s) needed to ascend a flight of stairs |
Change from baseline at 6 and 12 weeks
|
|
Stair ascent power
時間枠：Change from baseline at 6 and 12 weeks
|
The average power (Watt) produced during the stair ascent test |
Change from baseline at 6 and 12 weeks
|
|
Exercise adherence
時間枠：Total adherence over 12-week period
|
Number of sessions attended as a percentage of total sessions planned |
Total adherence over 12-week period
|
|
Absolute training load
時間枠：Consistently recorded throughout the 12-week intervention
|
The absolute load (kg) used during training sessions |
Consistently recorded throughout the 12-week intervention
|
|
Relative training load
時間枠：Consistently recorded throughout the 12-week intervention
|
The relative load (%1RM) used during training sessions |
Consistently recorded throughout the 12-week intervention
|
|
Number of repetitions
時間枠：Consistently recorded throughout the 12-week intervention
|
The number of repetitions (n) completed per set |
Consistently recorded throughout the 12-week intervention
|
|
Highest movement velocity within a set
時間枠：Consistently recorded throughout the 12-week intervention
|
The velocity (m/s) of the fastest repetition in a set (Vmax) |
Consistently recorded throughout the 12-week intervention
|
|
Lowest movement velocity within a set
時間枠：Consistently recorded throughout the 12-week intervention
|
The velocity (m/s) of the slowest repetition in a set (Vmin) |
Consistently recorded throughout the 12-week intervention
|
|
Velocity loss
時間枠：Consistently recorded throughout the 12-week intervention
|
The percentage difference between the highest and lowest movement velocity in a set = ([Vmax - Vmin] / Vmax) × 100 |
Consistently recorded throughout the 12-week intervention
|
|
Set-volume index
時間枠：Consistently recorded throughout the 12-week intervention
|
The number of repetitions × relative load (%1-RM) per set |
Consistently recorded throughout the 12-week intervention
|
|
Session-volume index
時間枠：Consistently recorded throughout the 12-week intervention
|
The sum of set volumes per session |
Consistently recorded throughout the 12-week intervention
|
協力者と研究者
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- S68434
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
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