수술로 제거할 수 없는 III-IV기 BRAF 돌연변이 흑색종 환자 치료에서 다브라페닙과 트라메티닙
BRAF V600E/K 돌연변이 흑색종에서 다브라페닙(NSC-763760) 및 트라메티닙(NSC-763093)의 간헐적 투여와 연속 투여의 무작위 2상 시험
This phase II trial compares the effect of dabrafenib and trametinib given continuously to given with a break in treatment (intermittent) in treating patients with stage III-IV melanoma that cannot be removed by surgery and contains a B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutation. Dabrafenib and trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving dabrafenib and trametinib with intermittent dosing may be as effect as when given continuously in treating patients with stage III-IV melanoma with a BRAF mutation that cannot be removed by surgery.
연구 개요
상태
상태
정황
정황
개입 / 치료
개입 / 치료
상세 설명
PRIMARY OBJECTIVE:
I. To compare progression-free survival with intermittent dosing and continuous dosing of dabrafenib and trametinib among patients with metastatic BRAF V600E/K mutant melanoma.
SECONDARY OBJECTIVES:
I. To estimate the frequency and severity of toxicities of the two dosing schedules.
II. To compare the frequency and severity of fever >= grade 1 per Common Terminology Criteria for Adverse Events (CTCAE) 4.0 of the two dosing schedules.
III. To compare the response rate (complete and partial response, confirmed and unconfirmed), overall survival, and survival after progression between the two dosing schedules on step 2.
TRANSLATIONAL MEDICINE OBJECTIVES:
I. To evaluate whether acquired molecular events leading to reactivation of the MAPK pathway are more common among patients on the continuous dosing arm than on the intermittent dosing arm using circulating tumor deoxyribonucleic acid (DNA) (ctDNA).
II. To assess the prognostic association between baseline biomarkers and early molecular events with progression free survival (PFS).
III. To explore the potential interaction between treatment arm and baseline biomarkers/early molecular events with PFS.
IV. To bank tissue and whole blood in anticipation of future studies to evaluate molecular events associated with clinical benefit and disease progression in patients treated with continuous versus intermittent dabrafenib and trametinib.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I (CONTINUOUS DOSING): Patients receive dabrafenib orally (PO) twice daily (BID) and trametinib PO once daily (QD) on days 1-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo positron emission tomography/computed tomography (PET/CT) or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression. Additionally, patients undergo blood sample collection, echocardiography (ECHO) or multigated acquisition scan (MUGA) on study.
ARM II (INTERMITTENT DOSING): Patients receive dabrafenib PO BID and trametinib PO QD on days 1-7 and 29-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo PET/CT or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression. Additionally, patients undergo blood sample collection, ECHO or MUGA on study.
After completion of study treatment, patients are followed up every 6 months for 3 years and then yearly for 2 years.
연구 유형
연구 유형
등록 (추정된)
등록
단계
단계
- 2 단계
연락처 및 위치
연구 장소
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Alabama
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Birmingham, Alabama, 미국, 35233
- University of Alabama at Birmingham Cancer Center
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Alaska
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Anchorage, Alaska, 미국, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, 미국, 99508
- Alaska Breast Care and Surgery LLC
-
Anchorage, Alaska, 미국, 99508
- Alaska Oncology and Hematology LLC
-
Anchorage, Alaska, 미국, 99508
- Alaska Women's Cancer Care
-
Anchorage, Alaska, 미국, 99508
- Anchorage Oncology Centre
-
Anchorage, Alaska, 미국, 99508
- Katmai Oncology Group
-
Anchorage, Alaska, 미국, 99508
- Providence Alaska Medical Center
-
Anchorage, Alaska, 미국, 99504
- Anchorage Radiation Therapy Center
-
Anchorage, Alaska, 미국, 99508
- Alaska Regional Hospital
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Fairbanks, Alaska, 미국, 99701
- Fairbanks Memorial Hospital
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Arizona
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Tucson, Arizona, 미국, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, 미국, 85719
- University of Arizona Cancer Center-North Campus
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Yuma, Arizona, 미국, 85364
- Onvida Health Yuma Medical Center
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Arkansas
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Fort Smith, Arkansas, 미국, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, 미국, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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Jonesboro, Arkansas, 미국, 72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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Little Rock, Arkansas, 미국, 72205
- University of Arkansas for Medical Sciences
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Little Rock, Arkansas, 미국, 72205
- John L McClellan Memorial Veterans Hospital
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Rogers, Arkansas, 미국, 72758
- Highlands Oncology Group - Rogers
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California
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Anaheim, California, 미국, 92806
- Kaiser Permanente-Anaheim
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Antioch, California, 미국, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, 미국, 93420
- PCR Oncology
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Baldwin Park, California, 미국, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, 미국, 90706
- Kaiser Permanente-Bellflower
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Burbank, California, 미국, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Dublin, California, 미국, 94568
- Epic Care-Dublin
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Emeryville, California, 미국, 94608
- Bay Area Breast Surgeons Inc
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Emeryville, California, 미국, 94608
- Epic Care Partners in Cancer Care
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Fontana, California, 미국, 92335
- Kaiser Permanente-Fontana
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Fremont, California, 미국, 94538
- Kaiser Permanente-Fremont
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Fresno, California, 미국, 93720
- Kaiser Permanente-Fresno
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Harbor City, California, 미국, 90710
- Kaiser Permanente South Bay
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Irvine, California, 미국, 92618
- Kaiser Permanente-Irvine
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Loma Linda, California, 미국, 92354
- Loma Linda University Medical Center
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Los Angeles, California, 미국, 90095
- UCLA / Jonsson Comprehensive Cancer Center
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Los Angeles, California, 미국, 90027
- Kaiser Permanente Los Angeles Medical Center
-
Los Angeles, California, 미국, 90034
- Kaiser Permanente West Los Angeles
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Martinez, California, 미국, 94553-3156
- Contra Costa Regional Medical Center
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Modesto, California, 미국, 95356
- Kaiser Permanente-Modesto
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Oakland, California, 미국, 94611
- Kaiser Permanente-Oakland
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Oakland, California, 미국, 94611
- Kaiser Permanente Oakland-Broadway
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Oakland, California, 미국, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, 미국, 94609
- Hematology and Oncology Associates-Oakland
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Oakland, California, 미국, 94609
- Bay Area Tumor Institute
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Panorama City, California, 미국, 91402
- Kaiser Permanente - Panorama City
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Rancho Cordova, California, 미국, 95670
- Kaiser Permanente-Rancho Cordova Cancer Center
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Rancho Mirage, California, 미국, 92270
- Eisenhower Medical Center
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Redwood City, California, 미국, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, 미국, 94801
- Kaiser Permanente-Richmond
-
Riverside, California, 미국, 92505
- Kaiser Permanente-Riverside
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Rohnert Park, California, 미국, 94928
- Rohnert Park Cancer Center
-
Roseville, California, 미국, 95678
- The Permanente Medical Group-Roseville Radiation Oncology
-
Roseville, California, 미국, 95661
- Kaiser Permanente-Roseville
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Sacramento, California, 미국, 95814
- Kaiser Permanente Downtown Commons
-
Sacramento, California, 미국, 95823
- Kaiser Permanente-South Sacramento
-
Sacramento, California, 미국, 95823
- South Sacramento Cancer Center
-
Sacramento, California, 미국, 95825
- Kaiser Permanente Sacramento Medical Center
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San Diego, California, 미국, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, 미국, 92108
- Kaiser Permanente-Rio San Diego
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San Francisco, California, 미국, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, 미국, 94115
- UCSF Medical Center-Mount Zion
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San Jose, California, 미국, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, 미국, 94577
- Kaiser Permanente San Leandro
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San Marcos, California, 미국, 92078
- Kaiser Permanente-San Marcos
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San Rafael, California, 미국, 94903
- Kaiser San Rafael-Gallinas
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San Rafael, California, 미국, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, 미국, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Rosa, California, 미국, 95403
- Kaiser Permanente-Santa Rosa
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South San Francisco, California, 미국, 94080
- Kaiser Permanente Cancer Treatment Center
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South San Francisco, California, 미국, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, 미국, 95210
- Kaiser Permanente-Stockton
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Vacaville, California, 미국, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, 미국, 94589
- Kaiser Permanente-Vallejo
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Walnut Creek, California, 미국, 94596
- Kaiser Permanente-Walnut Creek
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Walnut Creek, California, 미국, 94597
- Epic Care Cyberknife Center
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Woodland Hills, California, 미국, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, 미국, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, 미국, 80012
- The Medical Center of Aurora
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Aurora, Colorado, 미국, 80045
- UCHealth University of Colorado Hospital
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Boulder, Colorado, 미국, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, 미국, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, 미국, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, 미국, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, 미국, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, 미국, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, 미국, 80220
- Rose Medical Center
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Denver, Colorado, 미국, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, 미국, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, 미국, 80204
- Denver Health Medical Center
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Denver, Colorado, 미국, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, 미국, 80209
- The Women's Imaging Center
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Denver, Colorado, 미국, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, 미국, 80210
- AdventHealth Porter
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Durango, Colorado, 미국, 81301
- Mercy Medical Center
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Durango, Colorado, 미국, 81301
- CommonSpirit Cancer Center Mercy
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Englewood, Colorado, 미국, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, 미국, 80113
- Swedish Medical Center
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Fort Collins, Colorado, 미국, 80524
- Poudre Valley Hospital
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Golden, Colorado, 미국, 80401
- Mountain Blue Cancer Care Center
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Golden, Colorado, 미국, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, 미국, 81501
- Saint Mary's Hospital and Regional Medical Center
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Grand Junction, Colorado, 미국, 81505
- Grand Valley Oncology
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Greeley, Colorado, 미국, 80631
- Banner North Colorado Medical Center
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Greenwood Village, Colorado, 미국, 80111
- Rocky Mountain Cancer Centers-Greenwood Village
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Lafayette, Colorado, 미국, 80026
- Kaiser Permanente-Rock Creek
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Lafayette, Colorado, 미국, 80026
- Good Samaritan Hospital - Cancer Centers of Colorado
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Lakewood, Colorado, 미국, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Lakewood, Colorado, 미국, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
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Littleton, Colorado, 미국, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, 미국, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, 미국, 80124
- Kaiser Permanente-Lone Tree
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Lone Tree, Colorado, 미국, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, 미국, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, 미국, 80501
- Longmont United Hospital
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Longmont, Colorado, 미국, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, 미국, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, 미국, 80138
- Rocky Mountain Cancer Centers-Parker
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Parker, Colorado, 미국, 80138
- AdventHealth Parker
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Pueblo, Colorado, 미국, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, 미국, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, 미국, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, 미국, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, 미국, 80401
- Intermountain Health Lutheran Hospital
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Delaware
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Lewes, Delaware, 미국, 19958
- Beebe Medical Center
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Newark, Delaware, 미국, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, 미국, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, 미국, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, 미국, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, 미국, 19971
- Beebe Health Campus
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Seaford, Delaware, 미국, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, 미국, 19801
- Christiana Care Health System-Wilmington Hospital
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Florida
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Altamonte Springs, Florida, 미국, 32701
- AdventHealth Altamonte
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Aventura, Florida, 미국, 33180
- Mount Sinai Comprehensive Cancer Center at Aventura
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Fort Lauderdale, Florida, 미국, 33308
- Holy Cross Hospital
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Gainesville, Florida, 미국, 32610
- UF Health Cancer Institute - Gainesville
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Kissimmee, Florida, 미국, 34744
- AdventHealth Kissimmee
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Miami Beach, Florida, 미국, 33140
- Mount Sinai Medical Center
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Orlando, Florida, 미국, 32806
- Orlando Health Cancer Institute
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Orlando, Florida, 미국, 32803
- AdventHealth Orlando
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Orlando, Florida, 미국, 32803
- AdventHealth Medical Group Urology at Orlando
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Orlando, Florida, 미국, 32822
- AdventHealth East Orlando
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Winter Park, Florida, 미국, 32792
- AdventHealth Winter Park
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Georgia
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Atlanta, Georgia, 미국, 30322
- Emory University Hospital/Winship Cancer Institute
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Savannah, Georgia, 미국, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, 미국, 31404
- Memorial Health University Medical Center
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Savannah, Georgia, 미국, 31404
- Summit Cancer Care-Memorial
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Savannah, Georgia, 미국, 31405
- Summit Cancer Care-Candler
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Savannah, Georgia, 미국, 31404
- Low Country Cancer Care
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Hawaii
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Honolulu, Hawaii, 미국, 96813
- Queen's Medical Center
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Honolulu, Hawaii, 미국, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, 미국, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, 미국, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, 미국, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, 미국, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, 미국, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, 미국, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, 미국, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, 미국, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, 미국, 96813
- Island Urology
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Honolulu, Hawaii, 미국, 96819
- Kaiser Permanente Moanalua Medical Center
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Honolulu, Hawaii, 미국, 96859
- Tripler Army Medical Center
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Lihue, Hawaii, 미국, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, 미국, 96701
- Hawaii Cancer Care - Westridge
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‘Aiea, Hawaii, 미국, 96701
- Pali Momi Medical Center
-
‘Aiea, Hawaii, 미국, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, 미국, 96701
- The Cancer Center of Hawaii-Pali Momi
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Idaho
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Boise, Idaho, 미국, 83706
- Saint Alphonsus Cancer Care Center-Boise
-
Boise, Idaho, 미국, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, 미국, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, 미국, 83814
- Kootenai Health - Coeur d'Alene
-
Emmett, Idaho, 미국, 83617
- Walter Knox Memorial Hospital
-
Fruitland, Idaho, 미국, 83619
- Saint Luke's Cancer Institute - Fruitland
-
Meridian, Idaho, 미국, 83642
- Idaho Urologic Institute-Meridian
-
Meridian, Idaho, 미국, 83642
- Saint Luke's Cancer Institute - Meridian
-
Nampa, Idaho, 미국, 83687
- Saint Alphonsus Cancer Care Center-Nampa
-
Nampa, Idaho, 미국, 83687
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, 미국, 83854
- Kootenai Clinic Cancer Services - Post Falls
-
Sandpoint, Idaho, 미국, 83864
- Kootenai Clinic Cancer Services - Sandpoint
-
Twin Falls, Idaho, 미국, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Aurora, Illinois, 미국, 60504
- Rush-Copley Medical Center
-
Bloomington, Illinois, 미국, 61704
- Illinois CancerCare-Bloomington
-
Bloomington, Illinois, 미국, 61701
- OSF Saint Joseph Medical Center
-
Canton, Illinois, 미국, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, 미국, 62902
- Memorial Hospital of Carbondale
-
Carterville, Illinois, 미국, 62918
- SIH Cancer Institute
-
Carthage, Illinois, 미국, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, 미국, 62801
- Centralia Oncology Clinic
-
Danville, Illinois, 미국, 61832
- Carle at The Riverfront
-
Decatur, Illinois, 미국, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, 미국, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Effingham, Illinois, 미국, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, 미국, 62401
- Carle Physician Group-Effingham
-
Eureka, Illinois, 미국, 61530
- Illinois CancerCare-Eureka
-
Evanston, Illinois, 미국, 60201
- NorthShore University HealthSystem-Evanston Hospital
-
Galesburg, Illinois, 미국, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, 미국, 61401
- Illinois CancerCare-Galesburg
-
Geneva, Illinois, 미국, 60134
- Northwestern Medicine Cancer Center Delnor
-
Glenview, Illinois, 미국, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
-
Highland Park, Illinois, 미국, 60035
- NorthShore University HealthSystem-Highland Park Hospital
-
Kewanee, Illinois, 미국, 61443
- Illinois CancerCare-Kewanee Clinic
-
Macomb, Illinois, 미국, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, 미국, 61938
- Carle Physician Group-Mattoon/Charleston
-
Maywood, Illinois, 미국, 60153
- Loyola University Medical Center
-
Mount Vernon, Illinois, 미국, 62864
- SSM Health Good Samaritan
-
O'Fallon, Illinois, 미국, 62269
- Cancer Care Center of O'Fallon
-
Ottawa, Illinois, 미국, 61350
- Illinois CancerCare-Ottawa Clinic
-
Ottawa, Illinois, 미국, 61350
- Radiation Oncology of Northern Illinois
-
Pekin, Illinois, 미국, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, 미국, 61554
- OSF Saint Francis Radiation Oncology at Pekin
-
Peoria, Illinois, 미국, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, 미국, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, 미국, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, 미국, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru, Illinois, 미국, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, 미국, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, 미국, 61356
- Illinois CancerCare-Princeton
-
Rockford, Illinois, 미국, 61114
- UW Health Carbone Cancer Center Rockford
-
Silvis, Illinois, 미국, 61282
- MercyOne Genesis Silvis Cancer Center
-
Skokie, Illinois, 미국, 60076
- North Shore Medical Center
-
Springfield, Illinois, 미국, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, 미국, 62702
- Springfield Clinic
-
Springfield, Illinois, 미국, 62702
- Central Illinois Hematology Oncology Center
-
Springfield, Illinois, 미국, 62781
- Springfield Memorial Hospital
-
Swansea, Illinois, 미국, 62226
- Southwest Illinois Health Services LLP
-
Urbana, Illinois, 미국, 61801
- Carle Cancer Center
-
Urbana, Illinois, 미국, 61801
- The Carle Foundation Hospital
-
Warrenville, Illinois, 미국, 60555
- Northwestern Medicine Cancer Center Warrenville
-
Yorkville, Illinois, 미국, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Evansville, Indiana, 미국, 47713
- Deaconess Clinic Downtown
-
Michigan City, Indiana, 미국, 46360
- Franciscan Saint Anthony Health-Michigan City
-
Michigan City, Indiana, 미국, 46360
- Woodland Cancer Care Center
-
Mishawaka, Indiana, 미국, 46545
- Memorial Regional Cancer Center Day Road
-
Newburgh, Indiana, 미국, 47630
- Chancellor Center for Oncology
-
Richmond, Indiana, 미국, 47374
- Reid Health
-
South Bend, Indiana, 미국, 46601
- Memorial Hospital of South Bend
-
-
Iowa
-
Ames, Iowa, 미국, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, 미국, 50010
- McFarland Clinic - Ames
-
Bettendorf, Iowa, 미국, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Boone, Iowa, 미국, 50036
- McFarland Clinic - Boone
-
Clive, Iowa, 미국, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, 미국, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs, Iowa, 미국, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, 미국, 50801
- Greater Regional Medical Center
-
Davenport, Iowa, 미국, 52807
- Iowa Cancer Specialists
-
Davenport, Iowa, 미국, 52804
- MercyOne Genesis Davenport Cancer Center
-
Davenport, Iowa, 미국, 52803
- MercyOne Genesis Davenport Medical Center
-
Des Moines, Iowa, 미국, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, 미국, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, 미국, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, 미국, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, 미국, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, 미국, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, 미국, 50501
- McFarland Clinic - Trinity Cancer Center
-
Fort Dodge, Iowa, 미국, 50501
- UI Healthcare Mission Cancer and Blood - Fort Dodge
-
Jefferson, Iowa, 미국, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, 미국, 50158
- McFarland Clinic - Marshalltown
-
Sioux City, Iowa, 미국, 51101
- Siouxland Regional Cancer Center
-
West Des Moines, Iowa, 미국, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, 미국, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, 미국, 66720
- Cancer Center of Kansas - Chanute
-
Coffeyville, Kansas, 미국, 67337
- Coffeyville Regional Medical Center
-
Dodge City, Kansas, 미국, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, 미국, 67042
- Cancer Center of Kansas - El Dorado
-
Emporia, Kansas, 미국, 66801
- Newman Regional Health
-
Fort Scott, Kansas, 미국, 66701
- Cancer Center of Kansas - Fort Scott
-
Garden City, Kansas, 미국, 67846
- Central Care Cancer Center - Garden City
-
Garden City, Kansas, 미국, 67846
- Saint Catherine Hospital
-
Great Bend, Kansas, 미국, 67530
- Central Care Cancer Center - Great Bend
-
Great Bend, Kansas, 미국, 67530
- Saint Rose Ambulatory and Surgery Center
-
Hays, Kansas, 미국, 67601
- HaysMed
-
Independence, Kansas, 미국, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, 미국, 66160
- University of Kansas Cancer Center
-
Kansas City, Kansas, 미국, 66112
- University of Kansas Cancer Center-West
-
Kingman, Kansas, 미국, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, 미국, 66044
- Lawrence Memorial Hospital
-
Lenexa, Kansas, 미국, 66219
- Kansas Institute of Medicine Cancer and Blood Center
-
Lenexa, Kansas, 미국, 66219
- Minimally Invasive Surgery Hospital
-
Liberal, Kansas, 미국, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, 미국, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, 미국, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, 미국, 67114
- Cancer Center of Kansas - Newton
-
Olathe, Kansas, 미국, 66061
- The University of Kansas Cancer Center - Olathe
-
Overland Park, Kansas, 미국, 66210
- University of Kansas Cancer Center-Overland Park
-
Overland Park, Kansas, 미국, 66209
- Menorah Medical Center
-
Overland Park, Kansas, 미국, 66213
- Saint Luke's South Hospital
-
Parsons, Kansas, 미국, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, 미국, 66762
- Mercy Hospital Pittsburg
-
Pratt, Kansas, 미국, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, 미국, 67401
- Salina Regional Health Center
-
Salina, Kansas, 미국, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, 미국, 66606
- University of Kansas Health System Saint Francis Campus
-
Wellington, Kansas, 미국, 67152
- Cancer Center of Kansas - Wellington
-
Westwood, Kansas, 미국, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, 미국, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, 미국, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, 미국, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, 미국, 67208
- Associates In Womens Health
-
Winfield, Kansas, 미국, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown, Kentucky, 미국, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Corbin, Kentucky, 미국, 40701
- Baptist Health Corbin
-
Corbin, Kentucky, 미국, 40701
- Commonwealth Cancer Center-Corbin
-
Crestview Hills, Kentucky, 미국, 41017
- Oncology Hematology Care Inc-Crestview
-
Elizabethtown, Kentucky, 미국, 42701
- Baptist Health Hardin
-
Lexington, Kentucky, 미국, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, 미국, 40503
- Baptist Health Lexington
-
Lexington, Kentucky, 미국, 40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
London, Kentucky, 미국, 40741
- CommonSpirit Saint Joseph Hospital London
-
Louisville, Kentucky, 미국, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, 미국, 40202
- Jewish Hospital
-
Louisville, Kentucky, 미국, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, 미국, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, 미국, 40215
- Saints Mary and Elizabeth Hospital
-
Madisonville, Kentucky, 미국, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah, Kentucky, 미국, 42003
- Baptist Health Paducah
-
Shepherdsville, Kentucky, 미국, 40165
- Jewish Hospital Medical Center South
-
-
Maine
-
Augusta, Maine, 미국, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, 미국, 04401
- Eastern Maine Medical Center
-
Belfast, Maine, 미국, 04915
- MaineHealth Waldo Hospital
-
Biddeford, Maine, 미국, 04005
- MaineHealth Maine Medical Center - Biddeford
-
Brewer, Maine, 미국, 04412
- Lafayette Family Cancer Center-EMMC
-
Norway, Maine, 미국, 04268
- MaineHealth Stephens Hospital
-
Rockport, Maine, 미국, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, 미국, 04073
- MaineHealth Cancer Care and IV Therapy - Sanford
-
South Portland, Maine, 미국, 04106
- MaineHealth Cancer Care and IV Therapy - South Portland
-
-
Maryland
-
Baltimore, Maryland, 미국, 21204
- Greater Baltimore Medical Center
-
Bethesda, Maryland, 미국, 20889-5600
- Walter Reed National Military Medical Center
-
-
Massachusetts
-
Boston, Massachusetts, 미국, 02118
- Boston Medical Center
-
Burlington, Massachusetts, 미국, 01805
- Lahey Clinic
-
Winchester, Massachusetts, 미국, 01890
- Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care
-
-
Michigan
-
Adrian, Michigan, 미국, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, 미국, 48109
- University of Michigan Rogel Cancer Center
-
Battle Creek, Michigan, 미국, 49017
- Bronson Battle Creek
-
Dearborn, Michigan, 미국, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, 미국, 48201
- Wayne State University/Karmanos Cancer Institute
-
Farmington Hills, Michigan, 미국, 48334
- Weisberg Cancer Treatment Center
-
Farmington Hills, Michigan, 미국, 48336
- Corewell Health Farmington Hills Hospital
-
Grand Rapids, Michigan, 미국, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, 미국, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grand Rapids, Michigan, 미국, 49503
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
-
Grosse Pointe, Michigan, 미국, 48230
- William Beaumont Hospital-Grosse Pointe
-
Kalamazoo, Michigan, 미국, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, 미국, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, 미국, 49048
- Beacon Kalamazoo
-
Monroe, Michigan, 미국, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Muskegon, Michigan, 미국, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, 미국, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Port Huron, Michigan, 미국, 48060
- Lake Huron Medical Center
-
Port Huron, Michigan, 미국, 48060
- Huron Medical Center PC
-
Reed City, Michigan, 미국, 49677
- Corewell Health Reed City Hospital
-
Roseville, Michigan, 미국, 48066
- Michigan Cancer Specialists
-
Royal Oak, Michigan, 미국, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, 미국, 48073
- Oakland Medical Group
-
Royal Oak, Michigan, 미국, 48067
- Oakland Colon Rectal Associates
-
Royal Oak, Michigan, 미국, 48073
- Hematology Oncology Consultants PC-Royal Oak
-
Royal Oak, Michigan, 미국, 48073
- Corewell Health William Beaumont University Hospital
-
Saint Joseph, Michigan, 미국, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, 미국, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Sterling Heights, Michigan, 미국, 48312
- Premier Hematology Oncology Care
-
Sterling Heights, Michigan, 미국, 48314
- Mitchell Folbe MD PC
-
Traverse City, Michigan, 미국, 49684
- Munson Medical Center
-
Troy, Michigan, 미국, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, 미국, 48085
- Claudia BR Herke MD PC
-
Troy, Michigan, 미국, 48098
- Hematology Oncology Consultants PC-Troy
-
Troy, Michigan, 미국, 48085
- Corewell Health Beaumont Troy Hospital
-
Wyoming, Michigan, 미국, 49519
- University of Michigan Health - West
-
-
Minnesota
-
Brainerd, Minnesota, 미국, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, 미국, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, 미국, 55433
- Mercy Hospital
-
Duluth, Minnesota, 미국, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, 미국, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, 미국, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, 미국, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, 미국, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, 미국, 55432
- Unity Hospital
-
Hutchinson, Minnesota, 미국, 55350
- Hutchinson Area Health Care
-
Maple Grove, Minnesota, 미국, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, 미국, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, 미국, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, 미국, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, 미국, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, 미국, 55454
- Health Partners Inc
-
Monticello, Minnesota, 미국, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, 미국, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, 미국, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, 미국, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, 미국, 55101
- Regions Hospital
-
Saint Paul, Minnesota, 미국, 55102
- United Hospital
-
Shakopee, Minnesota, 미국, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, 미국, 55082
- Lakeview Hospital
-
Waconia, Minnesota, 미국, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, 미국, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, 미국, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Wyoming, Minnesota, 미국, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Jackson, Mississippi, 미국, 39216
- University of Mississippi Medical Center
-
Pascagoula, Mississippi, 미국, 39581
- Singing River Hospital
-
-
Missouri
-
Bolivar, Missouri, 미국, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, 미국, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, 미국, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, 미국, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, 미국, 63703
- Mercy Cancer Center - Cape Girardeau
-
Columbia, Missouri, 미국, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Independence, Missouri, 미국, 64057
- Centerpoint Medical Center LLC
-
Jefferson City, Missouri, 미국, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, 미국, 64804
- Freeman Health System
-
Joplin, Missouri, 미국, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, 미국, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, 미국, 64131
- The University of Kansas Cancer Center-South
-
Kansas City, Missouri, 미국, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, 미국, 64132
- Research Medical Center
-
Kansas City, Missouri, 미국, 64118
- Heartland Hematology and Oncology Associates Incorporated
-
Kansas City, Missouri, 미국, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, 미국, 64064
- University of Kansas Cancer Center - Lee's Summit
-
Lee's Summit, Missouri, 미국, 64086
- Saint Luke's East - Lee's Summit
-
Liberty, Missouri, 미국, 64068
- Liberty Hospital
-
Rolla, Missouri, 미국, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, 미국, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, 미국, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, 미국, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, 미국, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, 미국, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, 미국, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, 미국, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, 미국, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, 미국, 63128
- Mercy Hospital South
-
Sullivan, Missouri, 미국, 63080
- Missouri Baptist Sullivan Hospital
-
-
Montana
-
Anaconda, Montana, 미국, 59711
- Community Hospital of Anaconda
-
Billings, Montana, 미국, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, 미국, 59101
- Saint Vincent Healthcare
-
Billings, Montana, 미국, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, 미국, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, 미국, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, 미국, 59405
- Great Falls Clinic
-
Great Falls, Montana, 미국, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, 미국, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, 미국, 59901
- Logan Health Medical Center
-
Missoula, Montana, 미국, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, 미국, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, 미국, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, 미국, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, 미국, 68845
- Fred and Pamela Buffett Cancer Center - Kearney
-
Lincoln, Nebraska, 미국, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, 미국, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, 미국, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, 미국, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, 미국, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, 미국, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, 미국, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, 미국, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, 미국, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, 미국, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, 미국, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, 미국, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, 미국, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, 미국, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, 미국, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, 미국, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, 미국, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, 미국, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, 미국, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, 미국, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, 미국, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, 미국, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, 미국, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, 미국, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, 미국, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, 미국, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, 미국, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, 미국, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, 미국, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, 미국, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, 미국, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, 미국, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, 미국, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, 미국, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, 미국, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, 미국, 89102
- Desert West Surgery
-
Las Vegas, Nevada, 미국, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, 미국, 89169
- University Cancer Center
-
Las Vegas, Nevada, 미국, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, 미국, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, 미국, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, 미국, 89502
- Renown Regional Medical Center
-
Reno, Nevada, 미국, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, 미국, 89509
- Radiation Oncology Associates
-
-
New Jersey
-
Brick, New Jersey, 미국, 08724
- Ocean University Medical Center
-
Hackensack, New Jersey, 미국, 07601
- Hackensack University Medical Center
-
Holmdel, New Jersey, 미국, 07733
- Bayshore Community Hospital
-
Manahawkin, New Jersey, 미국, 08050
- Southern Ocean County Medical Center
-
Morristown, New Jersey, 미국, 07960
- Morristown Medical Center
-
Neptune City, New Jersey, 미국, 07753
- Jersey Shore Medical Center
-
Red Bank, New Jersey, 미국, 07701
- Riverview Medical Center/Booker Cancer Center
-
Summit, New Jersey, 미국, 07902
- Overlook Hospital
-
-
New York
-
Lake Success, New York, 미국, 11042
- Northwell Health/Center for Advanced Medicine
-
Middletown, New York, 미국, 10940
- Garnet Health Medical Center
-
New York, New York, 미국, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
Rochester, New York, 미국, 14642
- University of Rochester
-
-
North Carolina
-
Asheville, North Carolina, 미국, 28801
- Mission Hospital
-
Asheville, North Carolina, 미국, 28806
- Messino Cancer Centers
-
Asheville, North Carolina, 미국, 28803
- AdventHealth Infusion Center Asheville
-
Charlotte, North Carolina, 미국, 28204
- Novant Health Presbyterian Medical Center
-
Charlotte, North Carolina, 미국, 28207
- Oncology Specialists of Charlotte
-
Charlotte, North Carolina, 미국, 28262
- Southern Oncology Specialists-Charlotte
-
Charlotte, North Carolina, 미국, 28207
- Novant Health Carolina Surgical - Randolph
-
Clinton, North Carolina, 미국, 28328
- Southeastern Medical Oncology Center-Clinton
-
Clinton, North Carolina, 미국, 28328
- Sampson Radiation Oncology
-
Clyde, North Carolina, 미국, 28721
- AdventHealth Infusion Center Haywood
-
Goldsboro, North Carolina, 미국, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, 미국, 27534
- Wayne Memorial Hospital
-
Goldsboro, North Carolina, 미국, 27534
- Wayne Radiation Oncology
-
Hendersonville, North Carolina, 미국, 28791
- Margaret R Pardee Memorial Hospital
-
Hendersonville, North Carolina, 미국, 28792
- AdventHealth Hendersonville
-
Huntersville, North Carolina, 미국, 28078
- Novant Health Cancer Institute - Huntersville
-
Huntersville, North Carolina, 미국, 28078
- Southern Oncology Specialists-Huntersville
-
Jacksonville, North Carolina, 미국, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville, North Carolina, 미국, 28546
- Onslow Memorial Hospital
-
Kenansville, North Carolina, 미국, 28349
- ECU Health Oncology Kenansville
-
Kinston, North Carolina, 미국, 28501
- ECU Health Oncology Kinston
-
Matthews, North Carolina, 미국, 28105
- Matthews Radiation Oncology Center
-
Matthews, North Carolina, 미국, 28105
- Novant Health Cancer Institute - Matthews
-
Mooresville, North Carolina, 미국, 28117
- Novant Health Cancer Institute - Mooresville
-
Richlands, North Carolina, 미국, 28574
- ECU Health Oncology Richlands
-
-
North Dakota
-
Fargo, North Dakota, 미국, 58103
- Essentia Health Cancer Center-South University Clinic
-
-
Ohio
-
Beavercreek, Ohio, 미국, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, 미국, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, 미국, 44512
- Saint Elizabeth Boardman Hospital
-
Centerville, Ohio, 미국, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, 미국, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, 미국, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, 미국, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, 미국, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, 미국, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, 미국, 45242
- Oncology Hematology Care Inc-Blue Ash
-
Cincinnati, Ohio, 미국, 45202
- Oncology Hematology Care Inc-Eden Park
-
Cincinnati, Ohio, 미국, 45211
- Oncology Hematology Care Inc-Mercy West
-
Cincinnati, Ohio, 미국, 45230
- Oncology Hematology Care Inc-Anderson
-
Cincinnati, Ohio, 미국, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, 미국, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, 미국, 45255
- TriHealth Cancer Institute-Anderson
-
Columbus, Ohio, 미국, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, 미국, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, 미국, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, 미국, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, 미국, 43228
- Doctors Hospital
-
Columbus, Ohio, 미국, 43215
- Grant Medical Center
-
Columbus, Ohio, 미국, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, 미국, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, 미국, 45409
- Miami Valley Hospital
-
Dayton, Ohio, 미국, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, 미국, 45415
- Dayton Physician LLC - Englewood
-
Delaware, Ohio, 미국, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, 미국, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, 미국, 43015
- Grady Memorial Hospital
-
Fairfield, Ohio, 미국, 45014
- Oncology Hematology Care Inc-Healthplex
-
Findlay, Ohio, 미국, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, 미국, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, 미국, 45840
- Orion Cancer Care
-
Franklin, Ohio, 미국, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, 미국, 45005
- Dayton Physicians LLC-Atrium
-
Greenville, Ohio, 미국, 45331
- Wayne Hospital
-
Greenville, Ohio, 미국, 45331
- Dayton Physicians LLC-Wayne
-
Kettering, Ohio, 미국, 45429
- Kettering Medical Center
-
Kettering, Ohio, 미국, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, 미국, 45420
- First Dayton Cancer Care
-
Lancaster, Ohio, 미국, 43130
- Fairfield Medical Center
-
Marietta, Ohio, 미국, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, 미국, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, 미국, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Mount Vernon, Ohio, 미국, 43050
- Knox Community Hospital
-
Newark, Ohio, 미국, 43055
- Licking Memorial Hospital
-
Newark, Ohio, 미국, 43055
- Newark Radiation Oncology
-
Oregon, Ohio, 미국, 43616
- Saint Charles Hospital
-
Perrysburg, Ohio, 미국, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, 미국, 45662
- Southern Ohio Medical Center
-
Sidney, Ohio, 미국, 45365
- Dayton Physicians LLC-Wilson
-
Springfield, Ohio, 미국, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, 미국, 45504
- Springfield Regional Medical Center
-
Toledo, Ohio, 미국, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, 미국, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Troy, Ohio, 미국, 45373
- Upper Valley Medical Center
-
Troy, Ohio, 미국, 45373
- Dayton Physicians LLC - Troy
-
Warren, Ohio, 미국, 44484
- Saint Joseph Warren Hospital
-
West Chester, Ohio, 미국, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, 미국, 43081
- Saint Ann's Hospital
-
Wright-Patterson Air Force Base, Ohio, 미국, 45433
- Wright-Patterson Medical Center
-
Youngstown, Ohio, 미국, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, 미국, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, 미국, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, 미국, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, 미국, 73120
- Mercy Hospital Oklahoma City
-
Oklahoma City, Oklahoma, 미국, 73109
- Integris Southwest Medical Center
-
Oklahoma City, Oklahoma, 미국, 73142
- Integris Cancer Institute of Oklahoma
-
Tulsa, Oklahoma, 미국, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, 미국, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend, Oregon, 미국, 97701
- Saint Charles Health System
-
Clackamas, Oregon, 미국, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, 미국, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, 미국, 97420
- Bay Area Hospital
-
Newberg, Oregon, 미국, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, 미국, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Oregon City, Oregon, 미국, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, 미국, 97213
- Providence Portland Medical Center
-
Portland, Oregon, 미국, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, 미국, 97227
- Kaiser Permanente Northwest
-
Redmond, Oregon, 미국, 97756
- Saint Charles Health System-Redmond
-
-
Pennsylvania
-
Abington, Pennsylvania, 미국, 19001
- Jefferson Abington Hospital
-
Beaver, Pennsylvania, 미국, 15009
- UPMC-Heritage Valley Health System Beaver
-
Chadds Ford, Pennsylvania, 미국, 19317
- Christiana Care Health System-Concord Health Center
-
Danville, Pennsylvania, 미국, 17822
- Geisinger Medical Center
-
Greensburg, Pennsylvania, 미국, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Hazleton, Pennsylvania, 미국, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Johnstown, Pennsylvania, 미국, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg, Pennsylvania, 미국, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, 미국, 17044
- Lewistown Hospital
-
McKeesport, Pennsylvania, 미국, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Moon Township, Pennsylvania, 미국, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Pittsburgh, Pennsylvania, 미국, 15232
- UPMC Hillman Cancer Center
-
Pittsburgh, Pennsylvania, 미국, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, 미국, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, 미국, 15213
- UPMC-Presbyterian Hospital
-
Pittsburgh, Pennsylvania, 미국, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, 미국, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, 미국, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville, Pennsylvania, 미국, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, 미국, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, 미국, 17870
- Geisinger Medical Oncology-Selinsgrove
-
Seneca, Pennsylvania, 미국, 16346
- UPMC Cancer Center at UPMC Northwest
-
State College, Pennsylvania, 미국, 16801
- Geisinger Medical Group
-
Uniontown, Pennsylvania, 미국, 15401
- UPMC Uniontown Hospital Radiation Oncology
-
Washington, Pennsylvania, 미국, 15301
- UPMC Washington Hospital Radiation Oncology
-
West Reading, Pennsylvania, 미국, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, 미국, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, 미국, 17701
- UPMC Susquehanna
-
-
South Carolina
-
Anderson, South Carolina, 미국, 29621
- AnMed Health Cancer Center
-
Charleston, South Carolina, 미국, 29401
- Roper Hospital
-
Charleston, South Carolina, 미국, 29406
- Lowcountry Hematology Oncology PA-North Charleston
-
Charleston, South Carolina, 미국, 29414
- Bon Secours Saint Francis Hospital
-
Charleston, South Carolina, 미국, 29403
- Charleston Oncology - Roper
-
Charleston, South Carolina, 미국, 29414
- Charleston Oncology - Saint Francis
-
Charleston, South Carolina, 미국, 29414
- Lowcountry Oncology Associates - West Ashley
-
Gaffney, South Carolina, 미국, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, 미국, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, 미국, 29601
- Saint Francis Hospital
-
Greer, South Carolina, 미국, 29651
- Gibbs Cancer Center-Pelham
-
Mt. Pleasant, South Carolina, 미국, 29464
- Lowcountry Oncology Associates - Mount Pleasant
-
Spartanburg, South Carolina, 미국, 29303
- Spartanburg Medical Center
-
Union, South Carolina, 미국, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Rapid City, South Dakota, 미국, 57701
- Rapid City Regional Hospital
-
-
Tennessee
-
Bristol, Tennessee, 미국, 37620
- Wellmont Medical Associates Oncology and Hematology-Bristol
-
Bristol, Tennessee, 미국, 37620
- Bristol Regional Medical Center
-
Chattanooga, Tennessee, 미국, 37404
- Memorial Hospital
-
Hixson, Tennessee, 미국, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Johnson City, Tennessee, 미국, 37604
- Wellmont Medical Associates Oncology and Hematology-Johnson City
-
Kingsport, Tennessee, 미국, 37660
- Ballad Health Cancer Care - Kingsport
-
Kingsport, Tennessee, 미국, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Ooltewah, Tennessee, 미국, 37363
- Memorial GYN Plus
-
-
Texas
-
Bryan, Texas, 미국, 77802
- Saint Joseph Regional Cancer Center
-
-
Utah
-
American Fork, Utah, 미국, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, 미국, 84720
- Sandra L Maxwell Cancer Center
-
Farmington, Utah, 미국, 84025
- Farmington Health Center
-
Logan, Utah, 미국, 84321
- Logan Regional Hospital
-
Murray, Utah, 미국, 84107
- Intermountain Medical Center
-
Ogden, Utah, 미국, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, 미국, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, 미국, 84065
- Riverton Hospital
-
Salt Lake City, Utah, 미국, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, 미국, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, 미국, 84143
- LDS Hospital
-
South Jordan, Utah, 미국, 84009
- South Jordan Health Center
-
St. George, Utah, 미국, 84770
- Saint George Regional Medical Center
-
-
Virginia
-
Bristol, Virginia, 미국, 24201
- Ballad Health Cancer Care - Bristol
-
Norton, Virginia, 미국, 24273
- Ballad Health Cancer Care - Norton
-
-
Washington
-
Aberdeen, Washington, 미국, 98520
- Providence Regional Cancer System-Aberdeen
-
Anacortes, Washington, 미국, 98221
- Cancer Care Center at Island Hospital
-
Auburn, Washington, 미국, 98001
- MultiCare Auburn Medical Center
-
Bainbridge Island, Washington, 미국, 98110
- Virginia Mason Bainbridge Island Medical Center
-
Bellevue, Washington, 미국, 98004
- Overlake Medical Center
-
Bellevue, Washington, 미국, 98005
- Swedish Cancer Institute-Eastside Oncology Hematology
-
Bellingham, Washington, 미국, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, 미국, 98166
- Saint Anne Hospital
-
Centralia, Washington, 미국, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, 미국, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, 미국, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, 미국, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, 미국, 98002
- Virginia Mason Federal Way Medical Center
-
Federal Way, Washington, 미국, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, 미국, 98332
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
-
Gig Harbor, Washington, 미국, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, 미국, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, 미국, 99336
- Northwest Cancer Clinic
-
Lacey, Washington, 미국, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, 미국, 98499
- Saint Clare Hospital
-
Longview, Washington, 미국, 98632
- PeaceHealth Saint John Medical Center
-
Lynnwood, Washington, 미국, 98036
- Virginia Mason Lynnwood Medical Center
-
Port Townsend, Washington, 미국, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, 미국, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Poulsbo, Washington, 미국, 98370
- Peninsula Cancer Center
-
Puyallup, Washington, 미국, 98372
- MultiCare Good Samaritan Hospital
-
Puyallup, Washington, 미국, 98372
- Tacoma/Valley Radiation Oncology Centers-Puyallup
-
Renton, Washington, 미국, 98055
- Valley Medical Center
-
Seattle, Washington, 미국, 98101
- Virginia Mason Medical Center
-
Seattle, Washington, 미국, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, 미국, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, 미국, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, 미국, 98104
- Minor and James Medical PLLC
-
Seattle, Washington, 미국, 98104
- Pacific Gynecology Specialists
-
Sedro-Woolley, Washington, 미국, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, 미국, 98584
- Providence Regional Cancer System-Shelton
-
Silverdale, Washington, 미국, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane, Washington, 미국, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, 미국, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, 미국, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, 미국, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, 미국, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, 미국, 98405
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
-
Tacoma, Washington, 미국, 97405
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
-
Tacoma, Washington, 미국, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, 미국, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, 미국, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, 미국, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, 미국, 98597
- Providence Regional Cancer System-Yelm
-
-
Wisconsin
-
Burlington, Wisconsin, 미국, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Fond du Lac, Wisconsin, 미국, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, 미국, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, 미국, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, 미국, 54311
- Aurora BayCare Medical Center
-
Johnson Creek, Wisconsin, 미국, 53038
- University of Wisconsin Carbone Cancer Center - Johnson Creek
-
Kenosha, Wisconsin, 미국, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, 미국, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, 미국, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Marinette, Wisconsin, 미국, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, 미국, 54143
- Bay Area Medical Center
-
Milwaukee, Wisconsin, 미국, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, 미국, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, 미국, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, 미국, 53233
- Aurora Sinai Medical Center
-
Mukwonago, Wisconsin, 미국, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, 미국, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, 미국, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oshkosh, Wisconsin, 미국, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, 미국, 53406
- Aurora Cancer Care-Racine
-
Sheboygan, Wisconsin, 미국, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Summit, Wisconsin, 미국, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, 미국, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, 미국, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, 미국, 53188
- ProHealth Waukesha Memorial Hospital
-
Wauwatosa, Wisconsin, 미국, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, 미국, 53227
- Aurora West Allis Medical Center
-
-
Wyoming
-
Cheyenne, Wyoming, 미국, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, 미국, 82414
- Big Horn Basin Cancer Center
-
Cody, Wyoming, 미국, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, 미국, 82801
- Welch Cancer Center
-
-
참여기준
자격 기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
-
STEP 1: REGISTRATION
-
Patients must have histologically or cytologically confirmed stage IV or unresectable stage III BRAF V600E or BRAF V600K mutant melanoma
-
Patients must have BRAF V600E or BRAF V600K mutation identified by a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory; acceptable analytic techniques include but are not restricted to DNA sequencing, pyrosequencing, polymerase chain reaction (PCR), melting point assays, and immunohistochemistry
-
Contrast-enhanced CT scans of the neck, chest, abdomen and pelvis are required; a whole body PET/CT scan with diagnostic quality images and intravenous iodinated contrast may be used in lieu of a contrast enhanced CT of the neck, chest, abdomen and pelvis; contrast may be omitted if the treating investigator believes that exposure to contrast poses an excessive risk to the patient; patients must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1; all measurable lesions must be assessed within 28 days prior to registration; tests to assess non-measurable disease must be performed within 42 days prior to registration; all disease must be assessed and documented on the Baseline Tumor Assessment Form (RECIST 1.1)
-
Patients must not have received a prior BRAF or MEK inhibitor
-
Patients with a history of brain metastases are eligible if the patient is asymptomatic with no residual neurological dysfunction and has not received enzyme-reducing anti-epileptic drugs or corticosteroids for at least 7 days prior to registration
-
Patients must not have received any anti-cancer drug within 28 days prior to registration, and must not have received any nitrosoureas or mitomycin C within 42 days prior to registration
-
Patients must not have received any major surgery or immunotherapy within 28 days prior to registration
-
Patients must not have any unresolved toxicity greater than National Cancer Institute (NCI)-CTCAE version (v) 4.0 grade 1 from previous anti-cancer therapy except alopecia within 7 days prior to registration
-
Patients must be age >= 18 years of age
-
Absolute neutrophil count (ANC) >= 1,200/ul (obtained within 28 days prior to registration)
-
Platelets >= 100,000/ul (obtained within 28 days prior to registration)
-
Hemoglobin >= 9 g/dL (obtained within 28 days prior to registration)
-
Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (or =< 2.5 x upper limit of normal [ULN] with Gilbert's syndrome) (obtained within 28 days prior to registration)
-
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or < 5 x IULN for patients with known liver metastases) (obtained within 28 days prior to registration)
-
Serum albumin >= 2.5 g/dL (obtained within 28 days prior to registration)
-
Serum creatinine =< 1.5 mg/dL OR measured or calculated creatinine clearance >= 50 mL/min; creatinine measurements must be obtained within 28 days prior to registration
-
Patients must have lactate dehydrogenase (LDH) obtained within 28 days prior to registration in order to obtain baseline stratification information
-
Patients must have a left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (ILLN) by ECHO or MUGA within 28 days prior to registration
-
Patients must have corrected QT (QTc) =< 480 msec by electrocardiogram (ECG) (corrected using the Bazett's formula) within 28 days prior to registration
-
Patients with known history or current evidence of retinal vein occlusion (RVO) or central serous retinopathy (CSR) are not eligible:
-
History of RVO or CSR, or predisposing factors to RVO or CSR (e.g. uncontrolled glaucoma or ocular hypertension, uncontrolled systemic disease such as hypertension, diabetes mellitus, or history of hyperviscosity or hypercoagulability syndromes)
-
Visible retinal pathology as assessed by ophthalmic exam that is considered a risk factor for RVO or CSR such as:
- Evidence of new optic disc cupping
- Evidence of new visual field defects
- Intraocular pressure > 21 mmHg
-
NOTE: ophthalmic exam is required for all patients; exam must be obtained within 28 days prior to registration
-
-
Patients must be able to take oral medications; patients must not have any impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of protocol treatment (e.g. ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection)
-
Patients receiving anticoagulation treatment are allowed to participate with international normalized ratio (INR) established within the therapeutic range
-
Patients must not have a history of pneumonitis or interstitial lung disease
-
Patients must not have any grade II/III/IV cardiac disease as defined by the New York Heart Association criteria (i.e., patients with cardiac disease resulting in marked limitation of physical activity or resulting in inability to carry on any physical activity without discomfort), unstable angina pectoris, myocardial infarction within 6 months, or serious uncontrolled cardiac arrhythmia; abnormal cardiac valve morphology (>= grade 2) documented by echocardiogram (subjects with grade 1 abnormalities [i.e., mild regurgitation/stenosis]) can be entered on study; patients with a history of atrial fibrillation must have atrial fibrillation controlled for at least 30 days prior to registration
-
Patients with known hepatitis B or hepatitis C are not eligible, regardless of concomitant antiretroviral therapy or current viral load
-
Patients with known human immunodeficiency virus (HIV) may be eligible providing they meet the following additional criteria:
-
Cluster of differentiation (CD)4 cells >= 500/uL
-
Serum HIV viral load of < 25,000 IU/ml
-
No current antiretroviral therapy
- Tests must be obtained within 28 days prior to registration; patients who are HIV positive (+) and do not meet all of these criteria are not eligible for this study (HIV/hepatitis testing are not required for patients without known infection)
-
-
Pre-study history and physical must be obtained with 28 days prior to registration
-
Patients must have dermatology exam obtained within 28 days prior to registration to obtain baseline measurement; exam to be performed by treating physician or designated dermatologist
-
Patients must have Zubrod performance status of 0, 1 or 2
-
No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years; exception: patients with known history of colon cancer, cancer of the pancreas, or any cancer known to harbor an activating RAS mutation are ineligible regardless of stage or time since diagnosis
-
Patients must not be pregnant or nursing because of the risk of fetal harm; women/men of reproductive potential must have agreed to use an effective contraceptive method; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures; hormonal contraception is not allowed due to drug interactions which can render hormonal contraceptives ineffective
-
Patients must be offered the opportunity to participate in specimen banking
-
Patients with cutaneous or superficial lesions that do not require imaging guidance for biopsy must be willing to undergo biopsies for tissue submission and blood draws for translational medicine
-
Patients or their legally authorized representative must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
-
As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
-
STEP 2: RANDOMIZATION
-
After completing one cycle of therapy, patients will be registered for randomization between intermittent and continuous dosing, provided that they were eligible for the initial step 1 registration and satisfy the following criteria
-
Patients must not have unequivocal disease progression (by RECIST v1.1) during the first cycle; patients must have disease assessed using the same method as baseline within +/- 5 days of the day 56 scheduled assessment (between days 51-55 of cycle 1, or days 1-5 of cycle 2); all disease must be assessed and documented on the follow-up tumor assessment form (RECIST 1.1)
-
Patients must be registered to step 2: randomization within +/- 5 days of starting cycle 2; patients MUST NOT be registered prior to the day 56 disease assessment
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 없음(오픈 라벨)
팔의 수
무기와 개입
참가자 그룹 / 팔참가자 그룹 / 팔 |
개입 / 치료개입 / 치료 |
|---|---|
|
실험적: Arm I (continuous dosing)
Patients receive dabrafenib PO BID and trametinib PO QD on days 1-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo PET/CT or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression. Additionally, patients undergo blood sample collection, ECHO or MUGA on study. |
Undergo blood sample collection
다른 이름들:
Undergo ECHO
다른 이름들:
Undergo MUGA
다른 이름들:
Undergo CT or PET/CT
다른 이름들:
Undergo PET/CT
다른 이름들:
Given PO
다른 이름들:
Given PO
다른 이름들:
|
|
실험적: Arm II (intermittent dosing)
Patients receive dabrafenib PO BID and trametinib PO QD on days 1-7 and 29-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo PET/CT or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression. Additionally, patients undergo blood sample collection, ECHO or MUGA on study. |
Undergo blood sample collection
다른 이름들:
Undergo ECHO
다른 이름들:
Undergo MUGA
다른 이름들:
Undergo CT or PET/CT
다른 이름들:
Undergo PET/CT
다른 이름들:
Given PO
다른 이름들:
Given PO
다른 이름들:
|
연구는 무엇을 측정합니까?
주요 결과 측정
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Progression-free survival (PFS)
기간: Measured from date of randomization, assessed up to 5 years
|
Testing of the superiority of intermittent dosing of dabrafenib and trametinib compared to continuous dosing with these two same agents will be based on progression-free survival. Stratified Cox regression models stratified by stratification factors will be used for all analyses. |
Measured from date of randomization, assessed up to 5 years
|
2차 결과 측정
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Overall survival
기간: Up to 5 years
|
Overall survival between patients on each arm and survival after progression will be compared using Cox regression models. |
Up to 5 years
|
|
Response rates
기간: Up to 5 years
|
Response rates between arms will be compared using Fisher's exact test. |
Up to 5 years
|
|
Rates of fever
기간: Up to 5 years
|
Defined as >= grade 3 per Common Terminology Criteria for Adverse Events (CTCAE) version (v)4.0 with attribution possibly, probably, or definitely related to treatment; or any >= grade 1 per CTCAE v4.0 with attribution possibly, probably, or definitely related to treatment with chills, dehydration, hypotension, dizziness, or muscle weakness per CTCAE v4.0 with attribution possibly, probably, or definitely related to treatment reported during the same course. Rates of fever between arms will also be compared using Fisher's exact test. |
Up to 5 years
|
기타 결과 측정
기타 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Molecular events leading to reactivation of the MAPK pathway
기간: Up to 5 years
|
Compared between patients of the two treatment groups. |
Up to 5 years
|
|
Change in biomarkers associated with PFS of archived tissue
기간: Baseline up to 5 years
|
Cox regression analyses will be used to evaluate biomarkers' associations with PFS. |
Baseline up to 5 years
|
|
Interaction between baseline biomarkers and treatment arm
기간: Baseline up to 5 years
|
Cox regression analyses will be used to evaluate biomarkers' associations with PFS. |
Baseline up to 5 years
|
공동 작업자 및 조사자
수사관
수사관
- 수석 연구원: Alain P Algazi, SWOG Cancer Research Network
간행물 및 유용한 링크
일반 간행물
- Wang Y, Liu S, Yang Z, Algazi AP, Lomeli SH, Wang Y, Othus M, Hong A, Wang X, Randolph CE, Jones AM, Bosenberg MW, Byrum SD, Tackett AJ, Lopez H, Yates C, Solit DB, Ribas A, Piva M, Moriceau G, Lo RS. Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy. Cancer Cell. 2021 Oct 11;39(10):1375-1387.e6. doi: 10.1016/j.ccell.2021.07.023. Epub 2021 Aug 19.
- Algazi AP, Othus M, Daud AI, Lo RS, Mehnert JM, Truong TG, Conry R, Kendra K, Doolittle GC, Clark JI, Messino MJ, Moore DF Jr, Lao C, Faller BA, Govindarajan R, Harker-Murray A, Dreisbach L, Moon J, Grossmann KF, Ribas A. Continuous versus intermittent BRAF and MEK inhibition in patients with BRAF-mutated melanoma: a randomized phase 2 trial. Nat Med. 2020 Oct;26(10):1564-1568. doi: 10.1038/s41591-020-1060-8. Epub 2020 Oct 5.
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
연구 시작
기본 완료 (추정된)
기본 완료
연구 완료 (추정된)
연구 완료
연구 등록 날짜
최초 제출
최초 제출
QC 기준을 충족하는 최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정된)
처음 게시됨
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
마지막 업데이트 게시됨
QC 기준을 충족하는 마지막 업데이트 제출
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
추가 관련 MeSH 약관
기타 연구 ID 번호
기타 연구 ID 번호
- NCI-2014-01470
- U10CA032102 (미국 NIH 보조금/계약)
- U10CA180888 (미국 NIH 보조금/계약)
- NCI-2014-01470 (레지스트리 식별자: CTRP (Clinical Trial Reporting Program))
- S1320 (기타 식별자: CTEP)
- S1320 (기타 식별자: SWOG)
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