Molecular Profiling in Small Cell Lung Cancer (MPSCLC)

Inclusion Criteria:

• Age: between 18 and 75 years old.
• Sexes Eligible for Study: All
• Diagnosed of SCLC by IHC, and divided into extensive stage.
• The ECOG (Eastern Cooperative Oncology Group, ECOG) PS(performance status，PS) Scale score is 0 or 1.
• At least one measurable lesions by CT scan.
• Expect to survive for at least three months.
• Peripheral blood routine and liver and kidney function meet the following criterion (blood draw 7 days before the treatment begins) :
• The White Blood Cell (WBC) is greater than the 3.0×10^9/L or neutrophils (ANC) more than 1.5 x10^9/L;
• Hemoglobin (HGB) is greater than 80 g/L.
• Platelet (PLT) is greater than 100×10^9/L.
• (AST/ALT): Aspartate aminotransferase/Alanine aminotransferase<3.0 times of normal range.
• Total bilirubin (TBIL) < 1.5 times of normal range.
• Creatinine (CREAT) < 1.5 times of normal range.
• Female or male patients must adopt effective birth control measures.
• Informed consent forms provided. Patients must meet each of the above criteria.

Exclusion Criteria:

• Other pathological types of tumors ,rather than small cell lung cancer.
• Incorporating other tumors in the early diagnosis;
• Patients who have received chemotherapy, radiotherapy or any other anti-cancer treatment.
• Patients that known to be allergic to the drug components involved in the study;
• Patients with severe allergies or allergies;
• Pregnant or breastfeeding women;
• Patients with acute infection which is difficult to control;
• Drug abuse, substance abuse, long-term alcohol and AIDS(Acquired Immune Deficiency Syndrome) patients.

Candidates who meet each of the exclusion criteria will not included in the research.