Hyperglycemia as a Prognostic Factor In Acute Ischemic Stroke Patients
Background: Hyperglycemia is encountered in 20% to 40% of acute stroke patients, with or without a pre-morbid diagnosis of diabetes mellitus. Hyperglycemia is a risk factor for infarct expansion and poor outcome through the first 72 hours of onset in both diabetics and non-diabetics patients. This study was done to evaluate the glycemic status after acute ischemic stroke and assess its rule in influencing stroke outcome as regards the duration of hospital stay, motor deficit and mortality.
Methods: This retrospective study was conducted in Elzaiton specialized hospital from June 2016 to June 2017on 80 patients after approval of local medical ethical committee. Patients with acute ischemic stroke without other major comorbidities within 24 hours of onset of symptoms were included and divided into two groups, controlled group (Random blood suger not more than 150 mg/dl) and uncontrolled group ( Random blood suger more than 150 mg/dl). All patients were evaluated for GCS as a primary outcome and for hemorrhagic transformation, hospital stay duration, mechanical ventilation, need for vasopressors,hospital stay and mortality as secondary outcomes.
연구 개요
상태
상태
정황
정황
개입 / 치료
개입 / 치료
상세 설명
Patients and Methods This study was prospective study conducted in Elzaiton specialized hospital and Ain Shams University from june2016 to June 2017on 80 patients after approval of local medical ethical committee
All patients was subjected to the following
- Full clinical history …age, sex, weight and medical history
- GCS and motor deficit
- Random blood glucose level at admission and 4-6 times daily during hospital stay
- HbA1c on admission
- Hemodynamic monitoring
- Duration of hospital stay
- Thirty day mortality
- Other laboratory investigation to rule out other similar cause
- Follow up hemorrhagic transformation Study tools: Patients with acute ischemic stroke without other major comorbidities within 24 hours of onset of symptoms will be evaluated.
On ICU admission the random blood sugar was recorded and categorized to less than 150mg/dl (accepted) and more than 150mg/dl(not controlled). Also serial Random blood sugar daily was recorded and categorized to accepted or good control if less than 150mg/dl and not controlled if more than 150mg/dl.
Patients were divided into 2 groups Patients with accepted random blood sugar at admission and controlled blood sugar during hospital stay.
Patients with increased random blood sugar at admission and poor blood sugar control during hospital stay.
These data were collected and patients were observed as regards duration of hospital stay,hemorrhagic transformation, hospital stay duration and 30-days mortality
연구 유형
연구 유형
등록 (실제)
등록
연락처 및 위치
연구 장소
-
-
Ain Shams University Specialized Hospital
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Cairo, Ain Shams University Specialized Hospital, 이집트
- Hanaa El Gendy
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-
참여기준
자격 기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
샘플링 방법
연구 인구
Patients with acute ischemic stroke without other major comorbidities within 24 hours of onset of symptoms will be evaluated.
At ICU admission the random blood sugar was recorded and categorized to less than 150mg/dl (accepted) and more than 150mg/dl(not controlled). Also serial Random blood sugar daily was recorded and categorized to accepted or good control if less than 150mg/dl and not controlled if more than 150mg/dl.
Patients were divided into 2 groups Patients with accepted random blood sugar at admission and controlled blood sugar during hospital stay (B) Patients with increased random blood sugar at admission and poor blood sugar control during hospital stay These data were collected and patients were observed as regards duration of hospital stay, motor deficit improvement or worsening using Rating scale for muscle strength
설명
Inclusion criteria
- Age: 40-70years
- Sex: Any sex
- Patients with acute ischemic stroke without other major comorbidities within 24 hours of onset of symptoms were evaluated.
Exclusion criteria
- Subdural heamatoma, metabolic causes or transient ischemic attack
- Sub arachnoid heamorrage
- Heamorragic stroke
- Patients with major comorbidities at admission as end stage liver disease, end stage renal disease and malignant hypertension
- Patients with hyperglycemia at admission and controlled blood sugar during hospital stay
- Patients with DKA or hypoglycemia (RBS less than 70 mg dl)
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
그룹/코호트 수
코호트 및 개입
그룹/코호트그룹/코호트 |
개입 / 치료개입 / 치료 |
|---|---|
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Controlled
|
관찰 연구
|
|
Uncontrolled
|
관찰 연구
|
연구는 무엇을 측정합니까?
주요 결과 측정
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
GCS
기간: 30 days
|
GCS was assessed for 30 days
|
30 days
|
2차 결과 측정
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
30일 사망
기간: 30 일
|
30일 사망
|
30 일
|
공동 작업자 및 조사자
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
연구 시작
기본 완료 (실제)
기본 완료
연구 완료 (실제)
연구 완료
연구 등록 날짜
최초 제출
최초 제출
QC 기준을 충족하는 최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
처음 게시됨
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
마지막 업데이트 게시됨
QC 기준을 충족하는 마지막 업데이트 제출
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
추가 관련 MeSH 약관
기타 연구 ID 번호
기타 연구 ID 번호
- El Zaitoun Specialized Hospita
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
미국 FDA 규제 기기 제품 연구
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