뇌종양 환자를 위한 C-SMART vs BE Well
뇌종양 환자를 대상으로 한 C-SMART 대 BE Well의 신경인지 및 신경영상 결과에 대한 2상 무작위 대조 시험
The goal of this clinical trial is to learn about the acceptability and feasibility of Cognitive Strategies, Mindfulness, and Rehabilitation Therapy (C-SMART) and Brain health Education and Wellness (BE Well) in adults with brain tumors and their caregivers.
Participants will be assigned to one of the two groups:
- Cognitive Strategies, Mindfulness, and Rehabilitation Therapy (C-SMART) is a recently developed virtual intervention combining both cognitive rehabilitation with mindfulness meditation training. The manualized program consists of 8 weekly 1:1 tele intervention sessions, targeting cognitive weaknesses identified from baseline cognitive testing.
- Brain health Education and Wellness (BE Well) intervention consists of 8 weekly videos focused on maximizing brain health in the context of brain tumor.
Participants will also be asked to:
- participate in two in-person visits involving an MRI (if eligible for research MRIs) and neurocognitive tests
- complete a survey the the beginning and end of the study
- if in BE Well group, answer a few questions after watching each video
연구 개요
상태
상태
정황
정황
개입 / 치료
개입 / 치료
연구 유형
연구 유형
등록 (추정된)
등록
단계
단계
- 해당 없음
연락처 및 위치
연구 연락처
연구 연락처
- 이름: Sarah Braun, Ph.D
- 전화번호: 804-628-7028
- 이메일: sarah.braun@vcuhealth.org
연구 연락처 백업
- 이름: Brighton Payne, BS
- 전화번호: 804-628-6799
- 이메일: brightonph@vcu.edu
연구 장소
-
-
Virginia
-
Richmond, Virginia, 미국, 23298
- 모병
- Virginia Commonwealth University
-
연락하다:
- Sarah Braun, Ph.D
- 전화번호: 804-628-7028
- 이메일: sarah.braun@vcuhealth.org
-
수석 연구원:
- Sarah Braun, Ph.D
-
-
참여기준
자격 기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Patient Inclusion Criteria:
- Patient of Virginia Commonwealth University Neuro-Oncology clinic
- Confirmed primary brain tumor diagnosis by histology or neuro-oncologist review of imaging
- At least one domain of neurocognitive function >1.5 SD below the average or the individual's estimated premorbid functioning, using the expanded International Cognition and Cancer Task Force (ICCTF) clinical trials battery and Test of Premorbid Functioning (TOPF)62 for comparison; (3) >1 month post brain surgery and/or radiation therapy, if applicable;
- Estimated premorbid intelligence using TOPF >75.
- Patients must be age 18+ and
- Primarily English speaking.
Patient Exclusion Criteria:
- Presence of major neurocognitive impairment that would prevent participation in the intervention, and/or severe aphasia, and/or inability to understand and provide informed consent
- Referred participants who are suspected to have major neurocognitive impairment will be administered the Telephone Interview for Cognitive Status (TICS) during the pre-screening phase. Scores of <20 indicate major neurocognitive impairment and will result in exclusion from study participation;
- Inability to attend weekly telehealth appointments
- Clinically significant insomnia symptoms coupled with report that insomnia is more interfering than cognitive symptoms
- < 1 month post brain surgery and/or radiation therapy
- Unstable internet connection or an inability to work teleconferencing software. Participants will be supplied an iPad if they do not have an adequate device.
- Exclusion criteria for the MRI portion of the study includes (6)implants, objects, or devices that are not MR safe, as the MRI scan could cause them harm.
- Additionally, if female of childbearing years, they cannot be pregnant as the MRI scan may pose risk to the unborn fetus. Those participants who have implants, objects, or devices that are not MRI safe and/or are pregnant but are otherwise eligible will participate in all other study activities, excluding MRI.
Caregiver Inclusion Criteria
- Must enroll with a patient (see criteria above)
- Must be age 18+ and
- Primarily English speaking
Caregiver Exclusion Criteria
-N/A
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 지지 요법
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 더블
팔의 수
무기와 개입
참가자 그룹 / 팔참가자 그룹 / 팔 |
개입 / 치료개입 / 치료 |
|---|---|
|
실험적: Cognitive Strategies, Mindfulness, and Rehabilitation Therapy (C-SMART) - Patient
Modular tele-neuropsychological rehabilitation blending both cognitive rehabilitation with integrated mindfulness meditation training. |
Eight weekly, 45-60 minute, 1:1 tele-intervention sessions, targeting neurocognitive weaknesses identified from baseline cognitive testing |
|
실험적: Cognitive Strategies, Mindfulness, and Rehabilitation Therapy (C-SMART) - Caregiver
Modular tele-neuropsychological rehabilitation blending both cognitive rehabilitation with integrated mindfulness meditation training. |
Eight weekly, 45-60 minute, 1:1 tele-intervention sessions, targeting neurocognitive weaknesses identified from baseline cognitive testing |
|
실험적: Brain health Education and Wellness (BE Well) - Patient
Time-matched educational videos focused on maximizing brain health in the context of brain tumor. |
Eight weekly 45- to 60-minute video lectures |
|
실험적: Brain health Education and Wellness (BE Well) - Caregiver
Time-matched educational videos focused on maximizing brain health in the context of brain tumor. |
Eight weekly 45- to 60-minute video lectures |
연구는 무엇을 측정합니까?
주요 결과 측정
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Assess the feasibility of the C-SMART and BE Well protocols in brain tumor patients- Eligibility Rate
기간: From time participant indicates interest to screening completion, 4 weeks
|
The percentage of participants that are eligible to enroll |
From time participant indicates interest to screening completion, 4 weeks
|
|
Assess the feasibility of the C-SMART and BE Well protocols in brain tumor patients - Enrollment Rate
기간: From screening to intervention initiation, 8 weeks
|
The percentage of participants that enroll |
From screening to intervention initiation, 8 weeks
|
|
Assess the feasibility of the C-SMART and BE Well protocols in brain tumor patients -- retention rate
기간: From baseline to end of study, 28 weeks
|
The percentage of participants that complete the post-intervention data collection |
From baseline to end of study, 28 weeks
|
|
Assess the acceptability of the C-SMART and BE Well protocols in brain tumor patients -- intervention completion rate
기간: From baseline to end of intervention, 16 weeks
|
The percentage of participants that complete the the protocol assigned interventions |
From baseline to end of intervention, 16 weeks
|
|
Assess the acceptability of the C-SMART and BE Well protocols in brain tumor patients - Participant satisfaction ratings
기간: From baseline to post-intervention survey completion, 20 weeks
|
Participant ratings of satisfaction. Participants will rate the following questions on a scale from completely disagree to completely agree: C-SMART/BE Well Meets my approval; C-SMART/BE Well is appealing to the patient; "I like C-SMART/BE Well"; "I welcome C-SMART/BE Well". Additionally, participants will answer the following question on a scale from extremely dissatisfied to extremely satisfied: "When you signed up for the study, you were told that you would be randomized to either C-SMART or BE Well Videos. How satisfied are you with the group you were randomized to?" |
From baseline to post-intervention survey completion, 20 weeks
|
|
Assess the acceptability of the C-SMART and BE Well protocols in brain tumor patients - Participant recommendation ratings.
기간: From baseline to post-intervention survey completion, 20 weeks
|
Participant ratings of intervention recommendation Participants will answer the following question: Would "you" (the patient) recommend C-SMART/BE Well to other brain tumor patients? |
From baseline to post-intervention survey completion, 20 weeks
|
2차 결과 측정
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Assess the feasibility of the C-SMART and BE Well protocols in caregivers of brain tumor - Enrollment Rate
기간: From screening to intervention initiation, 8 weeks
|
The percentage of participants that enroll |
From screening to intervention initiation, 8 weeks
|
|
Assess the feasibility of the C-SMART and BE Well protocols in caregivers of brain tumor patients -- retention rate
기간: From baseline to end of study, 28 weeks
|
The percentage of participants that complete the post-intervention data collection |
From baseline to end of study, 28 weeks
|
|
Assess the acceptability of the C-SMART and BE Well protocols in caregivers of brain tumor patients - Participant satisfaction ratings
기간: From baseline to post-intervention survey completion, 20 weeks
|
Participant ratings of satisfaction. Participants will rate the following questions on a scale from completely disagree to completely agree: C-SMART/BE Well Meets my approval; C-SMART/BE Well is appealing to the patient; "I like C-SMART/BE Well"; "I welcome C-SMART/BE Well". Additionally, participants will answer the following question on a scale from extremely dissatisfied to extremely satisfied: "When you signed up for the study, you were told that your loved one would be randomized to either C-SMART or BE Well Videos. How satisfied are you with the group your loved one was randomized to?" |
From baseline to post-intervention survey completion, 20 weeks
|
|
Assess the acceptability of the C-SMART and BE Well protocols in caregivers of brain tumor patients - Participant recommendation ratings.
기간: From baseline to post-intervention survey completion, 20 weeks
|
Participant ratings of intervention recommendation. Participants will answer the following question: Would "you" (the caregiver) recommend C-SMART/BE Well to other caregivers? |
From baseline to post-intervention survey completion, 20 weeks
|
|
Investigate effect of interventions on neurocognitive tests Hopkins Verbal Learning Test (verbal learning and memory)
기간: Baseline to post-intervention assessment, up to 28 weeks
|
Changes in neurocognitive assessment scores (pre vs post intervention) between groups based on the Hopkins Verbal Learning Test (verbal learning and memory) neurocognitive test. Participant performance on the verbal learning and memory task will consist of three learning trials and a delay. A high score on the learning trials but a very low score on the delayed recall would show that the person can learn but has difficulty retrieving previously learned information. |
Baseline to post-intervention assessment, up to 28 weeks
|
|
Investigate effect of interventions on neurocognitive test Controlled Oral Word Association (verbal fluency)
기간: Baseline to post-intervention assessment, up to 28 weeks
|
Changes in neurocognitive assessment scores (pre vs post intervention) between groups based on the Controlled Oral Word Association (verbal fluency) neurocognitive test. Participant performance on the verbal fluency task will consist of generating words in 60 seconds on phonemic trials (words that start with a specific letter) and semantic trials (words that fall into a specific category). Scores are the number of correctly retrieved words. A higher raw score indicates greater verbal fluency. |
Baseline to post-intervention assessment, up to 28 weeks
|
|
Investigate effect of interventions on neurocognitive test Trail Making (attention and task switching)
기간: Baseline to post-intervention assessment, up to 28 weeks
|
Changes in neurocognitive assessment scores (pre vs post intervention) between groups based on Trail Making (processing speed and task switching). Participant performance will consist of time (in seconds) to complete a processing speed and switching task in which participants are asked to draw lines in sequential order, and then switch between two overlearned sequences. A shorter time to completion would indicate greater processing speed and task switching. |
Baseline to post-intervention assessment, up to 28 weeks
|
|
Investigate effect of interventions on subjective cognition
기간: Baseline to post-intervention assessment, up to 20 weeks
|
Changes in subjective cognition (pre vs post intervention) between groups based on the Neuro-Qol Short Form the National Institutes of Health (NIH) toolbox. Participants rate their experience of cognitive slips on 4 questions from "never" to "very often", and 4 questions from "no difficulty" to "cannot do". Higher scores indicate greater subjective cognition. Scores range from 8-40. Raw scores can be converted into standardized scores (T-scores) with a mean of 50 and a standard deviation (SD) of 10. Thus, a person who has a T-score of 60 is one SD above the average of the US general population. |
Baseline to post-intervention assessment, up to 20 weeks
|
|
Investigate effect of interventions on fatigue
기간: Baseline to post-intervention assessment, up to 20 weeks
|
Changes in fatigue (pre vs post intervention) between groups based on the Patient-Reported Outcomes Measurement Information System (PROMIS) Fatigue short form. Participants rate their experience of fatigue on 4 items from "not at all" to "very much". Higher scores indicate greater fatigue. Scores range from 4-20. Raw scores can be converted into standardized scores (T-scores) with a mean of 50 and a standard deviation (SD) of 10. Thus, a person who has a T-score of 60 is one SD above the average of the US general population. |
Baseline to post-intervention assessment, up to 20 weeks
|
|
Structural brain changes
기간: From baseline to post-outcome assessment, 28 weeks
|
Change in brain volume (pre vs. post intervention) between groups based on brain imaging (MRI) data. The volume of lateral ventricle in the hemisphere opposite to the tumor will be measured, using 3D Slicer (https://www.slicer.org) to calculate the ventricular volume at each time point which will serve as an index of diffuse cerebral volume loss. |
From baseline to post-outcome assessment, 28 weeks
|
공동 작업자 및 조사자
협력자
협력자
수사관
수사관
- 수석 연구원: Sarah Braun, Ph.D, Virginia Commonwealth University
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
연구 시작
기본 완료 (추정된)
기본 완료
연구 완료 (추정된)
연구 완료
연구 등록 날짜
최초 제출
최초 제출
QC 기준을 충족하는 최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
처음 게시됨
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
마지막 업데이트 게시됨
QC 기준을 충족하는 마지막 업데이트 제출
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
기타 연구 ID 번호
기타 연구 ID 번호
- MCC-25-22557
- HM300000218 (기타 식별자: Virginia Commonwealth University)
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
IPD 계획 설명
There are no plans to share individual patient data "IPD" at this time.
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
미국 FDA 규제 기기 제품 연구
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