Betamethasone vs Dextrose Injections in Trigger Finger
Comparison of Ultrasound-Guided Betamethasone and Dextrose Injections in the Treatment of Trigger Finger: A Randomized Controlled Trial
This study aims to compare the effectiveness of ultrasound-guided betamethasone and dextrose injections in patients with trigger finger.
Trigger finger is a common hand condition characterized by pain, clicking, and locking of the finger due to tendon entrapment at the A1 pulley. Corticosteroid injections are widely used as a first-line treatment; however, they may be associated with potential side effects.
Dextrose injection is an alternative treatment that may promote tissue healing through regenerative mechanisms. However, there is limited high-quality evidence regarding its effectiveness in trigger finger.
In this randomized controlled trial, patients will be assigned to receive either betamethasone or dextrose injection under ultrasound guidance. The primary outcome will be pain intensity measured by the Numeric Rating Scale (NRS). Secondary outcomes will include triggering severity, hand function, grip and pinch strength, and fine motor skills evaluated over a 12-week follow-up period.
The results of this study may help determine whether dextrose injection is a safe and effective alternative to corticosteroid treatment in trigger finger.
연구 개요
상태
상태
정황
정황
개입 / 치료
개입 / 치료
상세 설명
Trigger finger, also known as stenosing tenosynovitis, is a common hand disorder characterized by pain, catching, and locking of the affected digit due to impaired gliding of the flexor tendon at the A1 pulley. It can significantly impair hand function and quality of life.
Corticosteroid injections are widely accepted as an effective first-line treatment for trigger finger. However, potential adverse effects such as skin atrophy, tendon rupture, and systemic effects, particularly in patients with metabolic disorders, have led to increasing interest in alternative treatment options.
Dextrose injection has emerged as a potential alternative treatment modality in musculoskeletal disorders. However, there is limited high-quality evidence evaluating its effectiveness in trigger finger.
The aim of this prospective, randomized controlled trial is to compare the clinical effectiveness of ultrasound-guided betamethasone injection and dextrose injection in patients with trigger finger.
Eligible participants aged 18 to 75 years with clinically diagnosed trigger finger of at least 4 weeks' duration will be enrolled. Patients will be randomly assigned to one of two groups. One group will receive an ultrasound-guided injection of 1 ml lidocaine and 1 ml betamethasone, while the other group will receive an ultrasound-guided injection of 1 ml lidocaine and 1 ml 30% dextrose solution (resulting in a final concentration of 15% dextrose). All injections will be performed under sterile conditions at the A1 pulley level.
The study is designed as a randomized, participant-, injector-, and assessor-blinded trial. The injector will be blinded to the injectate using opaque-covered syringes. Randomization will be performed by an independent researcher who will not be involved in outcome assessment.
The primary outcome of the study is the change in pain intensity, assessed using the Numeric Rating Scale (NRS).
Secondary outcomes include triggering severity assessed using the Modified Quinnell classification, functional status assessed using the Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) questionnaire, grip and pinch strength, and fine motor skills evaluated with the Purdue Pegboard test.
Outcome assessments will be conducted at baseline, 1 hour, 2 weeks, 4 weeks, and 12 weeks after injection, according to the predefined schedule of each outcome measure.
This study is expected to provide high-quality evidence regarding the effectiveness of dextrose injection as a potential alternative to corticosteroid treatment in trigger finger.
연구 유형
연구 유형
등록 (추정된)
등록
단계
단계
- 해당 없음
연락처 및 위치
연구 연락처
연구 연락처
- 이름: Merve Yıldız, MD
- 전화번호: +905350229993
- 이메일: merveyildizdr@gmail.com
연구 장소
-
-
-
Istanbul, 터키 (Türkiye), 34098
- 모병
- Istanbul University - Cerrahpasa, Cerrahpasa Faculty of Medicine
-
연락하다:
- Merve Yıldız, MD
- 전화번호: +905350229993
- 이메일: merveyildizdr@gmail.com
-
수석 연구원:
- Merve Yıldız, MD
-
-
참여기준
자격 기준
자격 기준
공부할 수 있는 나이
- 성인
- 고령자
건강한 자원 봉사자를 받아들입니다
설명
Inclusion Criteria:
- Age between 18 and 75 years
- Clinical diagnosis of trigger finger
- Presence of symptoms for at least 4 weeks
Exclusion Criteria:
- Previous surgery on the affected finger
- Injection treatment to the affected finger within the previous 3 months
- Active local or systemic infection
- Active malignancy
- Active inflammatory rheumatic disease (e.g., rheumatoid arthritis, ankylosing spondylitis, polymyalgia rheumatica, vasculitis)
- Uncontrolled diabetes mellitus and/or uncontrolled hypertension
- Autoimmune connective tissue diseases (e.g., systemic lupus erythematosus, antiphospholipid syndrome, systemic sclerosis, Sjögren syndrome, polymyositis, dermatomyositis, adult-onset Still's disease)
- Coagulopathy that increases the risk of injection procedures
- Pregnancy
- Known allergy or hypersensitivity to lidocaine, betamethasone, or dextrose
- Mental impairment or severe psychiatric disorder that may interfere with study participation or informed consent
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 삼루타
팔의 수
무기와 개입
참가자 그룹 / 팔참가자 그룹 / 팔 |
개입 / 치료개입 / 치료 |
|---|---|
|
활성 비교기: Betamethasone Injection
Participants in this arm will receive an ultrasound-guided injection of 1 ml lidocaine combined with 1 ml betamethasone at the A1 pulley level for the treatment of trigger finger.
|
Ultrasound-guided injection of 1 ml lidocaine combined with 1 ml betamethasone administered at the A1 pulley level for the treatment of trigger finger.
다른 이름들:
|
|
활성 비교기: Dextrose Injection
Participants in this arm will receive an ultrasound-guided injection of 1 ml lidocaine combined with 1 ml 30% dextrose solution (final concentration 15%) at the A1 pulley level for the treatment of trigger finger.
|
Ultrasound-guided injection of 1 ml lidocaine combined with 1 ml 30% dextrose solution resulting in a final concentration of 15% dextrose, administered at the A1 pulley level for the treatment of trigger finger.
|
연구는 무엇을 측정합니까?
주요 결과 측정
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Change in pain intensity assessed by Numeric Rating Scale (NRS)
기간: Baseline, 1 hour, 2 weeks, 4 weeks, and 12 weeks
|
Pain intensity will be evaluated using the 11-point Numeric Rating Scale (NRS), where 0 indicates no pain and 10 indicates worst imaginable pain.
|
Baseline, 1 hour, 2 weeks, 4 weeks, and 12 weeks
|
2차 결과 측정
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Change in triggering severity assessed by Modified Quinnell classification
기간: Baseline, 2 weeks, 4 weeks, and 12 weeks
|
Triggering severity will be evaluated using the Modified Quinnell classification system.
|
Baseline, 2 weeks, 4 weeks, and 12 weeks
|
|
Change in hand function assessed by QuickDASH
기간: Baseline, 2 weeks, 4 weeks, and 12 weeks
|
Functional status will be assessed using the Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) questionnaire.
|
Baseline, 2 weeks, 4 weeks, and 12 weeks
|
|
Change in grip strength
기간: Baseline, 2 weeks, 4 weeks, and 12 weeks
|
Grip strength will be measured using a hand dynamometer.
|
Baseline, 2 weeks, 4 weeks, and 12 weeks
|
|
Change in pinch strength
기간: Baseline, 2 weeks, 4 weeks, and 12 weeks
|
Pinch strength will be measured using a pinch meter.
|
Baseline, 2 weeks, 4 weeks, and 12 weeks
|
|
Change in fine motor skills assessed by Purdue Pegboard test
기간: Baseline, 4 weeks, and 12 weeks
|
Fine motor skills and manual dexterity will be evaluated using the Purdue Pegboard test.
|
Baseline, 4 weeks, and 12 weeks
|
공동 작업자 및 조사자
간행물 및 유용한 링크
일반 간행물
- Liu DH, Tsai MW, Lin SH, Chou CL, Chiu JW, Chiang CC, Kao CL. Ultrasound-Guided Hyaluronic Acid Injections for Trigger Finger: A Double-Blinded, Randomized Controlled Trial. Arch Phys Med Rehabil. 2015 Dec;96(12):2120-7. doi: 10.1016/j.apmr.2015.08.421. Epub 2015 Sep 1.
- Rahman AN, Herman H, Bujangga KG, Sugiarto J. Grade III bilateral trigger thumbs treated by prolotherapy: a case report. World Journal of Current Medical and Pharmaceutical Research. 2022;4(6):143-146.
- Yoon Y, Hwang JH, Lee J, Suryadi T, Suhaimi A, Shim J, Lam KHS. Unusual Triggering of the Finger Caused by Distal Flexor Tendinopathy: Successful Treatment With Ultrasound-Guided Prolotherapy. Cureus. 2025 Dec 19;17(12):e99605. doi: 10.7759/cureus.99605. eCollection 2025 Dec.
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
연구 시작
기본 완료 (추정된)
기본 완료
연구 완료 (추정된)
연구 완료
연구 등록 날짜
최초 제출
최초 제출
QC 기준을 충족하는 최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
처음 게시됨
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
마지막 업데이트 게시됨
QC 기준을 충족하는 마지막 업데이트 제출
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
키워드
추가 관련 MeSH 약관
기타 연구 ID 번호
기타 연구 ID 번호
- TF-Dextrose-2026
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
IPD 계획 설명
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
미국 FDA 규제 기기 제품 연구
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .