The Effectiveness Of Home-Based Circuit Training On Eye Pressure And Eye Nerve Structures In Patients With Glaucoma
The Effectiveness Of Home-Based Circuit Training On Intraocular Pressure, Retinal Nerve Fiber Layers And Choroidal Thickness In Patients With Glaucoma
The goal of this randomised control trial is to learn about the effect of home based circuit training on patients with primary glaucoma.
The main questions to answer are:
- Is there any difference of intraocular pressure (IOP) in patient with primary glaucoma after 6 weeks and 12 weeks who is performing home-based circuit training compared to patient not performing home-based circuit training?
- Is there any difference of retina nerve fibre layer in patient with primary glaucoma after 6 weeks and 12 weeks who is performing home-based circuit training compared to patient not performing home-based circuit training?
- Is there any difference of choroidal thickness layer in patient with primary glaucoma after 6 weeks and 12 weeks who is performing home-based circuit training compared to patient not performing home-based circuit training?
Researchers will compare patients with primary glaucoma who are performing home-based circuit training and not performing home-based circuit training to see if any affect to intraocular pressure, retina nerve fibre layer and choroidal thickness.
연구 개요
상태
상태
정황
정황
개입 / 치료
개입 / 치료
상세 설명
Glaucoma is the leading cause of irreversible blindness worldwide. According to a study, it is known that East Asia has the highest number of people with glaucoma (25.20 million), followed by South- Central Asia (17.06 million) and South East Asia (6.92 million). The global prevalence of glaucoma especially in people aged 40 to 80 years is estimated to be 3.5%. The most important risk factor for glaucoma is aging. With the growing number and proportion of older population, it is projected that 111.8 million people will have glaucoma in 2040. The degeneration of retinal ganglion cells (RGCs) and their axons result in an irreversible loss of vision that has a strong correlation with increasing age. The relationship between exercise and glaucoma is complex as various components of physical activity such as fluctuations in blood pressure, body posture, and Valsalva manoeuvres can influence intraocular pressure (IOP) and ocular perfusion pressure, both of which may play roles in glaucoma pathophysiology.
The investigator would like to evaluate the effect of 12 weeks home-based circuit training on intraocular pressure (IOP), retinal nerve fibre layer thickness (RNFL) and choroidal thickness in patients with primary glaucoma. This is a randomised controlled study involving primary glaucoma patients who are attending ophthalmology clinic at Hospital Universiti Sains Malaysia. Evaluation of study sample includes baseline ocular examination, IOP and Optical Coherence Tomography Retinal Nerve Fibre Layer (OCT RNFL) and sub foveal choroidal thickness. Subjects who fulfil the inclusion and exclusion criteria for the study will be selected.
Patients in Group A will perform home-based circuit training for 12 weeks while other Group B (control group) will not perform home-based circuit training. IOP, OCT RNFL and choroidal thickness measurement will be taken at baseline, 6 weeks and 12 weeks post recruitment of subjects. All patients will be given exercise diary to note down their exercise adherence.
연구 유형
연구 유형
등록 (추정된)
등록
단계
단계
- 해당 없음
연락처 및 위치
연구 연락처
연구 연락처
- 이름: THARANI ELUMALAI, MBBS
- 전화번호: +60123789645
- 이메일: tharanicrystaline93@gmail.com
연구 장소
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Kelantan
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Kubang Kerian, Kelantan, 말레이시아, 16150
- Universiti Sains Malaysia
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연락하다:
- THARANI ELUMALAI, MBBS
- 전화번호: 0123789645
- 이메일: tharanicrystaline93@gmail.com
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참여기준
자격 기준
자격 기준
공부할 수 있는 나이
- 성인
- 고령자
건강한 자원 봉사자를 받아들입니다
설명
Inclusion Criteria:
- Age ≥ 18 - 70 years old
- Known case of POAG, PACG, JOAG, NTG
- Phakic without visually significant cataract
- Pseudophakic for more than 3 months prior to recruitment
- Achieved target IOP
- Physically not performing routine exercises
Exclusion Criteria:
- Bilateral eye visual acuity of less than 6/60
- Bilateral eye visual field defect of less than 10 degrees from fixation
- Patient with media opacities that affect the reliability of OCT measurements such as cornea opacity, dense cataract with Lens opacification classification system (LOCS III) of more than grade 2, vitreous haemorrhage
- Patient who underwent intraocular surgery (other than uncomplicated cataract surgery), including anti-vascular endothelial growth factor injection within past 6 months
- Ocular disease such as cornea ulcer, uveitis, age-related macula degeneration
- Physical disabilities such as stroke, limbs amputation
- Uncontrolled systemic diseases eg diabetes, hypertension
- Morbid Obesity (BMI > 40)
- Dementia or any psychiatric diseases
- Smoking
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 지지 요법
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 더블
팔의 수
무기와 개입
참가자 그룹 / 팔참가자 그룹 / 팔 |
개입 / 치료개입 / 치료 |
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실험적: Home-Based Circuit Training
Patients in Group A will be performing home-based circuit training three times per week for 12 weeks.
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Participants assigned to the intervention group will perform a home-based circuit training program in addition to receiving standard glaucoma care.
The exercise program consists of seven home-based exercises, including two aerobic exercises and five resistance-based exercises performed in a circuit format.
Each session will last 30 minutes for week 1-6 and 60 minutes for week 7-12.
It is performed three times per week on alternate days for 12 weeks, and is conducted at moderate intensity.
Participants will continue their prescribed glaucoma medications throughout the study.
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간섭 없음: Control Group
Patients in Group B will not will be performing
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연구는 무엇을 측정합니까?
주요 결과 측정
주요 결과 측정
결과 측정 |
기간 |
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Intraocular pressure
기간: Baseline, at 6 weeks and at 12 weeks
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Baseline, at 6 weeks and at 12 weeks
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Retinal Nerve Fiber Layer
기간: Baseline, at 6 weeks and at 12 weeks
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Baseline, at 6 weeks and at 12 weeks
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Choroidal Thickness
기간: Baseline, at 6 weeks and at 12 weeks
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Baseline, at 6 weeks and at 12 weeks
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공동 작업자 및 조사자
간행물 및 유용한 링크
일반 간행물
- Zhu MM, Lai JSM, Choy BNK, Shum JWH, Lo ACY, Ng ALK, Chan JCH, So KF. Physical exercise and glaucoma: a review on the roles of physical exercise on intraocular pressure control, ocular blood flow regulation, neuroprotection and glaucoma-related mental health. Acta Ophthalmol. 2018 Sep;96(6):e676-e691. doi: 10.1111/aos.13661. Epub 2018 Jan 16.
- Gonzalez-Devesa D, Suarez-Iglesias D, Diz JC, Esmerode-Iglesias A, Ayan C. Systematic review on the impact of exercise on intraocular pressure in glaucoma patients. Int Ophthalmol. 2024 Aug 19;44(1):351. doi: 10.1007/s10792-024-03216-4.
- Anderson AJ. Exercise and Glaucoma: Positive Steps Toward Finding Another Modifiable Risk Factor to Prevent Vision Loss. Ophthalmology. 2019 Jul;126(7):965-966. doi: 10.1016/j.ophtha.2018.12.035. No abstract available.
- Tribble JR, Hui F, Joe M, Bell K, Chrysostomou V, Crowston JG, Williams PA. Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma. Cells. 2021 Feb 1;10(2):295. doi: 10.3390/cells10020295.
- Gildea D, Doyle A, O'Connor J. The Effect of Exercise on Intraocular Pressure and Glaucoma. J Glaucoma. 2024 Jun 1;33(6):381-386. doi: 10.1097/IJG.0000000000002411. Epub 2024 May 10.
연구 기록 날짜
연구 주요 날짜
연구 시작 (추정된)
연구 시작
기본 완료 (추정된)
기본 완료
연구 완료 (추정된)
연구 완료
연구 등록 날짜
최초 제출
최초 제출
QC 기준을 충족하는 최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
처음 게시됨
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
마지막 업데이트 게시됨
QC 기준을 충족하는 마지막 업데이트 제출
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
기타 연구 ID 번호
기타 연구 ID 번호
- HBCT-GLAU-2026-01
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
IPD 계획 설명
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
미국 FDA 규제 기기 제품 연구
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