The Cohort Construction Project of Peking University Third Hospital
2026년 8월 9일 업데이트: Peking University Third Hospital
The specific construction goals for this period include enrolling 100,000 individuals for dynamic follow-up, perfecting the biobank by collecting biological samples from 20,000 individuals, and gathering health questionnaire information from 30,000 people.
The near-term goals emphasize the use of health check-up data combined with advanced artificial intelligence technologies to build disease prediction models and explore the association between retinal photographs and overall health status, which will assist in early screening and personalized interventions for high-risk populations.
The medium- to long-term goals focus on biological age-related research, utilizing telomere length and multi-omics technologies to assess the differences between biological age and chronological age and analyze their key influencing factors.
Data collection will be implemented through the health check-up centers of multiple campuses of PUTH.
연구 개요
상태
상태
모병
정황
정황
개입 / 치료
개입 / 치료
상세 설명
The construction of a health check-up follow-up cohort holds significant importance for public health research. Since its establishment in 2022, the Health Check-up Cohort of Peking University Third Hospital (PUTH) has been operational for three years. The cohort features comprehensive health check-up indicators, including physical examination, biochemical tests, cancer screening, and 13 other major categories of indicators. It is equipped with a robust data management system and collaborates with the Clinical Epidemiology Research Center and the biobank. A multidimensional database has been established, covering health check-up information, health questionnaires, and biological samples of the study subjects. The cohort adopts a bidirectional study design, with the retrospective part covering individuals who underwent health check-ups since 2011 and the prospective part continuously enrolling subjects since 2022. As of 2023, the PUTH Health Check-up Cohort has collected health check-up data from over 80,000 study subjects, with the longest follow-up duration reaching 12 years, forming a longitudinal health database with continuous follow-up.
The cohort construction project has achieved favorable research outcomes, with a total of 14 academic papers published, including 8 SCI papers, and two invention patents granted. In addition, the cohort has collaborated with clinical departments within the hospital and has previously received funding from both internal and external horizontal and vertical projects. The primary focus has been on conducting research on medical reference value ranges and disease prevention and control among the health check-up cohort population. Building on the solid foundation of previous work, the cohort study will continue to optimize and expand, aiming to align with international large-scale cohorts by constructing a health check-up cohort with a large sample size, long follow-up duration, and high follow-up density.
The specific construction goals for this period include enrolling 100,000 individuals for dynamic follow-up, perfecting the biobank by collecting biological samples from 20,000 individuals, and gathering health questionnaire information from 30,000 people. The near-term goals emphasize the use of health check-up data combined with advanced artificial intelligence technologies to build disease prediction models and explore the association between retinal photographs and overall health status, which will assist in early screening and personalized interventions for high-risk populations. The medium- to long-term goals focus on biological age-related research, utilizing telomere length and multi-omics technologies to assess the differences between biological age and chronological age and analyze their key influencing factors. Data collection will be implemented through the health check-up centers of multiple campuses of PUTH.
The construction of this health check-up cohort provides a solid data foundation for the prevention of chronic diseases, individualized health management, and research on healthy aging. Through long-term follow-up and large-scale data collection, it can reveal disease risk factors, develop early prediction models, and in combination with biomarkers and multi-omics technologies, it helps explore the relationship between biological age and health status, promoting the development of precision medicine and the optimization of public health policies.
연구 유형
연구 유형
관찰
등록 (추정된)
등록
100000
연락처 및 위치
이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.
연구 연락처
연구 연락처
- 이름: Liyuan Tao, PhD
- 전화번호: +86 13581552613
- 이메일: tendytly@163.com
연구 연락처 백업
- 이름: Honghai He, MPH
- 전화번호: +86 15101049480
- 이메일: hehonghai2011@126.com
연구 장소
-
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Beijing Municipality
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Beijing, Beijing Municipality, 중국, 100191
- 모병
- Physical Examination Center, Peking University Third Hospital
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연락하다:
- Liyuan Tao, PhD
- 전화번호: +86 13581552613
- 이메일: tendytly@163.com
-
연락하다:
- Peng Wang, MMed
- 전화번호: +86 13601015655
- 이메일: bysywp@126.com
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수석 연구원:
- Peng Wang, MMed
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부수사관:
- Liyuan Tao, PhD
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부수사관:
- Ying Che, MS
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참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
자격 기준
공부할 수 있는 나이
- 성인
- 고령자
건강한 자원 봉사자를 받아들입니다
아니
샘플링 방법
비확률 샘플
연구 인구
The study population consists of individuals who voluntarily undergo health examinations at the Physical Examination Center of Peking University Third Hospital.
Participants are recruited from group health examination populations (including employees from functional community units such as government agencies, schools, and enterprises) who have undergone at least two consecutive health examinations at the center.
The study includes both retrospective and prospective participants, with long-term follow-up and biospecimen collection (serum) stored in the hospital's biobank.
설명
Inclusion Criteria:
- Age ≥ 18 years. Participants must be from group health examination populations who have undergone at least two consecutive health examinations at our Physical Examination Center.
Exclusion Criteria:
- Failure to provide informed consent. Incomplete data, including incomplete health examination self-administered questionnaires.
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
그룹/코호트 수
1
코호트 및 개입
그룹/코호트그룹/코호트 |
개입 / 치료개입 / 치료 |
|---|---|
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Functional Community Health Examination Cohort
This cohort consists of employees from functional community units (such as government agencies, schools, and enterprises) who undergo regular health examinations at the Physical Examination Center of Peking University Third Hospital.
The cohort integrates both retrospective and prospective data, with long-term follow-up and biospecimen collection (serum) stored in the hospital's biobank.
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This is an observational study designed to investigate the mental health status and its influencing factors in the general physical examination population.
No interventions are assigned to participants based on a protocol.
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연구는 무엇을 측정합니까?
주요 결과 측정
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Systolic and Diastolic Blood Pressure
기간: through study completion, an average of 3 year
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Blood pressure will be measured using a standardized mercury sphygmomanometer after at least 5 minutes of rest in a seated position.
Both systolic blood pressure (SBP) and diastolic blood pressure (DBP) will be recorded.
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through study completion, an average of 3 year
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Fasting Lipid Profile (Total Cholesterol, Triglycerides, LDL-C, and HDL-C)
기간: through study completion, an average of 3 year
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Venous blood samples will be collected after at least 8 hours of overnight fasting.
Serum levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) will be measured using an automated biochemical analyzer at the central laboratory of Peking University Third Hospital.
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through study completion, an average of 3 year
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Fasting Blood Glucose (FBG)
기간: through study completion, an average of 3 year
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Fasting venous blood samples will be collected after at least 8 hours of overnight fasting.
Serum glucose levels will be measured using an automated biochemical analyzer at the central laboratory of Peking University Third Hospital.
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through study completion, an average of 3 year
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Glycated Hemoglobin (HbA1c)
기간: through study completion, an average of 3 year
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Fasting venous blood samples will be collected and analyzed using high-performance liquid chromatography (HPLC) at the central laboratory of Peking University Third Hospital.
HbA1c reflects average blood glucose levels over the previous 2 to 3 months.
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through study completion, an average of 3 year
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Complete Blood Count (CBC)
기간: through study completion, an average of 3 year
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Fasting venous blood samples will be collected and analyzed using an automated hematology analyzer at the central laboratory of Peking University Third Hospital.
Key parameters include white blood cell count (WBC), red blood cell count (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and platelet count (PLT).
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through study completion, an average of 3 year
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Routine Urinalysis
기간: through study completion, an average of 3 year
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Midstream clean-catch urine specimens will be collected and analyzed using an automated urine analyzer and microscopy at the central laboratory of Peking University Third Hospital.
Key parameters include urine specific gravity, pH, protein, glucose, ketones, bilirubin, urobilinogen, nitrite, leukocyte esterase, and microscopic examination of red blood cells, white blood cells, and casts.
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through study completion, an average of 3 year
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Liver Function Panel
기간: through study completion, an average of 3 year
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Fasting venous blood samples will be collected and analyzed using an automated biochemical analyzer at the central laboratory of Peking University Third Hospital.
Key parameters include alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total bilirubin (TBIL), direct bilirubin (DBIL), total protein (TP), and albumin (ALB).
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through study completion, an average of 3 year
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Renal Function Panel
기간: through study completion, an average of 3 year
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Fasting venous blood samples will be collected and analyzed using an automated biochemical analyzer at the central laboratory of Peking University Third Hospital.
Key parameters include serum creatinine (Cr), blood urea nitrogen (BUN), uric acid (UA), and estimated glomerular filtration rate (eGFR) calculated using the CKD-EPI or MDRD equation.
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through study completion, an average of 3 year
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Pulmonary Assessment
기간: through study completion, an average of 3 year
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Chest X-ray or low-dose chest CT will be performed according to standardized protocols at the Radiology Department of Peking University Third Hospital.
Findings will be interpreted by certified radiologists.
Results will be reported as presence or absence of pulmonary abnormalities (e.g., nodules, infiltrates, or other clinically significant findings).
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through study completion, an average of 3 year
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Abdominal Ultrasound Assessment
기간: through study completion, an average of 3 year
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Abdominal ultrasound will be performed according to standardized protocols at the Radiology Department of Peking University Third Hospital for evaluation of the liver, gallbladder, pancreas, spleen, and kidneys.
Findings will be interpreted by certified radiologists.
Results will be reported as presence or absence of abnormalities in each organ.
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through study completion, an average of 3 year
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Carotid Artery Ultrasound Assessment
기간: through study completion, an average of 3 year
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Carotid artery ultrasound will be performed according to standardized protocols at the Radiology Department of Peking University Third Hospital for assessment of carotid intima-media thickness (CIMT) and plaque detection.
CIMT will be measured in millimeters (mm).
Plaque will be reported as present or absent.
All findings will be interpreted by certified radiologists.
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through study completion, an average of 3 year
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2차 결과 측정
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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BMI
기간: through study completion, an average of 3 year
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Body composition will be measured using bioelectrical impedance analysis (BIA) or dual-energy X-ray absorptiometry (DXA) at the Physical Examination Center of Peking University Third Hospital.
Body mass index (BMI) will be calculated as weight in kilograms divided by height in meters squared (kg/m²).
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through study completion, an average of 3 year
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Body Fat Percentage
기간: through study completion, an average of 3 year
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Body composition will be measured using bioelectrical impedance analysis (BIA) or dual-energy X-ray absorptiometry (DXA) at the Physical Examination Center of Peking University Third Hospital.
Body fat percentage (BFP) will be reported as a percentage (%).
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through study completion, an average of 3 year
|
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Visceral Fat Area
기간: through study completion, an average of 3 year
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Body composition will be measured using bioelectrical impedance analysis (BIA) or dual-energy X-ray absorptiometry (DXA) at the Physical Examination Center of Peking University Third Hospital.
Visceral fat area (VFA) will be reported in square centimeters (cm²).
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through study completion, an average of 3 year
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Skeletal Muscle Mass
기간: through study completion, an average of 3 year
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Body composition will be measured using bioelectrical impedance analysis (BIA) or dual-energy X-ray absorptiometry (DXA) at the Physical Examination Center of Peking University Third Hospital.
Skeletal muscle mass (SMM) will be reported in kilograms (kg).
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through study completion, an average of 3 year
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Handgrip Strength
기간: through study completion, an average of 3 year
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Physical fitness will be assessed by trained exercise physiologists at the Physical Examination Center of Peking University Third Hospital using standardized protocols.
Handgrip strength will be measured using a handheld dynamometer and reported in kilograms (kg).
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through study completion, an average of 3 year
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Back Strength
기간: through study completion, an average of 3 year
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Back strength will be assessed by trained exercise physiologists at the Physical Examination Center of Peking University Third Hospital using a back dynamometer following standardized protocols.
Results will be measured and reported in kilograms (kg).
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through study completion, an average of 3 year
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Vertical Jump Height
기간: through study completion, an average of 3 year
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Vertical jump height will be assessed by trained exercise physiologists at the Physical Examination Center of Peking University Third Hospital using a force platform or jump mat following standardized protocols.
Results will be measured and reported in centimeters (cm).
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through study completion, an average of 3 year
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Estimated VO₂max
기간: through study completion, an average of 3 year
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Cardiorespiratory function will be assessed by trained exercise physiologists at the Physical Examination Center of Peking University Third Hospital using standardized protocols.
Estimated maximal oxygen uptake (VO₂max) will be calculated and reported in milliliters per kilogram per minute (ml/kg/min).
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through study completion, an average of 3 year
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기타 결과 측정
기타 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Thyroid Function Panel
기간: Measured at baseline and at each annual health examination visit
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Fasting venous blood samples will be collected and analyzed using an automated chemiluminescence immunoassay analyzer at the central laboratory of Peking University Third Hospital.
Key parameters include thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4).
Additional parameters (e.g., total T3, total T4, anti-thyroglobulin antibody [TG-Ab], and anti-thyroid peroxidase antibody [TPO-Ab]) may be measured as clinically indicated.
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Measured at baseline and at each annual health examination visit
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Inflammatory Biomarker Panel
기간: Measured at baseline and at each annual health examination visit
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Fasting venous blood samples will be collected and analyzed at the central laboratory of Peking University Third Hospital.
The inflammatory biomarker panel includes high-sensitivity C-reactive protein (hsCRP) measured by immunoturbidimetry, and a panel of serum cytokines (including but not limited to IL-6, TNF-α, IL-10, and IL-17A) measured using a multiplex immunoassay system.
Additional inflammatory markers such as white blood cell count (WBC) and ferritin will also be assessed.
All measurements will be performed following standardized protocols.
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Measured at baseline and at each annual health examination visit
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공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
수사관
수사관
- 연구 책임자: Peng Wang, MMed, Peking University Third Hospital
연구 기록 날짜
이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.
연구 주요 날짜
연구 시작 (실제)
연구 시작
2025년 2월 21일
기본 완료 (추정된)
기본 완료
2027년 12월 31일
연구 완료 (추정된)
연구 완료
2027년 12월 31일
연구 등록 날짜
최초 제출
최초 제출
2026년 7월 16일
QC 기준을 충족하는 최초 제출
QC 기준을 충족하는 최초 제출
2026년 8월 9일
처음 게시됨 (실제)
처음 게시됨
2026년 8월 12일
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
마지막 업데이트 게시됨
2026년 8월 12일
QC 기준을 충족하는 마지막 업데이트 제출
QC 기준을 충족하는 마지막 업데이트 제출
2026년 8월 9일
마지막으로 확인됨
마지막으로 확인됨
2026년 7월 1일
추가 정보
이 연구와 관련된 용어
기타 연구 ID 번호
기타 연구 ID 번호
- BYSYDL2024010
- IRB00006761-M20250131 (기타 식별자: Peking University Third Hospital Medical Science Research Ethics Committee)
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
아니요
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
아니
미국 FDA 규제 기기 제품 연구
아니
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .