Innate-like and NK Signatures in Chronic-Treated HIV Infection INSTINCT-HIV (INSTINCT-HIV)

The target population consists of adults aged 18 years or over living with HIV who are being monitored by the Department of Infectious and Tropical Diseases at the Hospices Civils de Lyon and who have been receiving prolonged, continuous, suppressive antiviral treatment for at least five full years.

Participants must meet the following criteria:

• a plasma viral load that has been consistently undetectable since the start of ART and for more than 5 years;
• must not have experienced, since the start of antiviral treatment, more than two isolated episodes of virological rebound ('blips') ≥ 100 copies/mL, measured in a peripheral blood sample taken during a routine consultation.

Inclusion Criteria:

• Be aged 18 or over;
• Be living with HIV-1 infection;
• Be under the care of the Department of Infectious and Tropical Diseases at the Lyon university Hopsital (Hospices Civils de Lyon);
• Have been receiving continuous ART for at least 5 full years;
• Have a consistently undetectable plasma HIV viral load whilst on ART;
• Have experienced no more than two isolated episodes of virological rebound ('blips') ≥ 100 copies/mL;
• Have usable biological samples for the planned analyses and/or agree to the collection of samples required for the research;
• Have received written and verbal information about the research;
• Have signed the written consent form prior to any research-specific procedures.

Exclusion Criteria:

• Patients who have taken part in an interventional therapeutic trial specifically targeting an HIV cure strategy likely to have a lasting effect on the immunological or virological parameters under investigation;
• Patients who have experienced more than two episodes of virological rebound ≥ 100 copies/mL whilst on ART;
• Pregnant women, women in labour or breastfeeding women;
• Persons deprived of their liberty by judicial or administrative order;
• Persons subject to a legal protection order;
• Adults subject to a legal protection measure (guardianship, curatorship);
• Persons admitted to a health or social care facility for purposes other than research;
• Persons receiving psychiatric care;
• Persons who have expressed their objection to participating in the research or to the use of their data and biological samples.