- ICH GCP
- 미국 임상 시험 레지스트리
- 임상시험 NCT01034098
Ventilatory Constraint, Breathing Pattern and Ventilatory Responses in Obese Postmenopausal Women
연구 개요
상세 설명
Obesity-related changes in lung volumes have shown to affect breathing mechanisms. During exercise, altered breathing mechanisms increase potential for expiratory flow limitation and compromise exercise capacity. Estrogen and progesterone are potent respiratory stimulants, and their effects in the physiologic regulation of breathing are down-regulated after menopause. Therefore, we theorized that the combined obesity and reduced sex hormone levels after menopause work as a double jeopardy to cause mechanical ventilatory constraint which aggravates dyspnea sensation during exercise, and thus a reduction in exercise capacity. The purpose of this study was to exam the dynamic lung volumes in obese post-menopausal women (without hormone replacement therapy) during exercise and their correlations with dyspnea.
From doctoral referral and advertisement, 24 obese (BMI ≧ 27 kg/m2) and 26 lean post-menopausal women were recruited for the study. Pulmonary function and body composition were measured at rest. A maximal flow volume loop (MFVL) was obtained at baseline. All subjects then performed an incremental exercise test on a cycle ergometer with workload increasing 25 watts every 3 min. During exercise, at each workload, the tidal exercise FV loops were obtained and an inspiratory capacity (IC) maneuver was conducted to assess changes in end-expiratory lung volume (EELV) and end inspiratory lung volume (EILV). Dyspnea and leg fatigue were assessed using the Borg scale. Analysis of variance with repeated measurements was used to test the significance of the mean differences between the two groups during exercise. Linear regression analysis was used to determine whether changes in dynamic lung volumes during exercise were related to changes in Borg scores. Statistical significance was established at p<0.05.
연구 유형
등록 (실제)
연락처 및 위치
연구 장소
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Taipei, 대만
- School and Graduate Institute of Physical Therapy, National Taiwan University
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
샘플링 방법
연구 인구
설명
Inclusion Criteria:
- Postmenopausal women (for at least 1 year)
- Age below 69 y/o
- Not receiving hormone replacement therapy
Exclusion Criteria:
- Cardiopulmonary disease
- Musculoskeletal disease affecting results of maximal exercise test
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
코호트 및 개입
그룹/코호트 |
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Post-menopausal women
Post-menopausal women (without hormone replacement therapy)
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
기간 |
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Dynamic lung volume: end-expiratory lung volume (EELV), end-inspiratory lung volume (EILV)
기간: At least 1 year post-menopause
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At least 1 year post-menopause
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2차 결과 측정
결과 측정 |
기간 |
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Pulmonary function
기간: At least 1 year post-menopause
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At least 1 year post-menopause
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Breathing pattern
기간: At least 1 year post-menopause
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At least 1 year post-menopause
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Ventilatory response
기간: At least 1 year post-menopause
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At least 1 year post-menopause
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Visual analog scale (VAS) for dyspnea and leg fatigue
기간: At least 1 year post-menopause
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At least 1 year post-menopause
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공동 작업자 및 조사자
수사관
- 수석 연구원: Li-Ying Wang, Ph.D., School and Graduate Institute of Physical Therapy, National Taiwan University
연구 기록 날짜
연구 주요 날짜
연구 시작
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (추정)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
기타 연구 ID 번호
- 9461701144
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