Ventilatory Constraint, Breathing Pattern and Ventilatory Responses in Obese Postmenopausal Women
研究概览
详细说明
Obesity-related changes in lung volumes have shown to affect breathing mechanisms. During exercise, altered breathing mechanisms increase potential for expiratory flow limitation and compromise exercise capacity. Estrogen and progesterone are potent respiratory stimulants, and their effects in the physiologic regulation of breathing are down-regulated after menopause. Therefore, we theorized that the combined obesity and reduced sex hormone levels after menopause work as a double jeopardy to cause mechanical ventilatory constraint which aggravates dyspnea sensation during exercise, and thus a reduction in exercise capacity. The purpose of this study was to exam the dynamic lung volumes in obese post-menopausal women (without hormone replacement therapy) during exercise and their correlations with dyspnea.
From doctoral referral and advertisement, 24 obese (BMI ≧ 27 kg/m2) and 26 lean post-menopausal women were recruited for the study. Pulmonary function and body composition were measured at rest. A maximal flow volume loop (MFVL) was obtained at baseline. All subjects then performed an incremental exercise test on a cycle ergometer with workload increasing 25 watts every 3 min. During exercise, at each workload, the tidal exercise FV loops were obtained and an inspiratory capacity (IC) maneuver was conducted to assess changes in end-expiratory lung volume (EELV) and end inspiratory lung volume (EILV). Dyspnea and leg fatigue were assessed using the Borg scale. Analysis of variance with repeated measurements was used to test the significance of the mean differences between the two groups during exercise. Linear regression analysis was used to determine whether changes in dynamic lung volumes during exercise were related to changes in Borg scores. Statistical significance was established at p<0.05.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Taipei、台湾
- School and Graduate Institute of Physical Therapy, National Taiwan University
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Postmenopausal women (for at least 1 year)
- Age below 69 y/o
- Not receiving hormone replacement therapy
Exclusion Criteria:
- Cardiopulmonary disease
- Musculoskeletal disease affecting results of maximal exercise test
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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Post-menopausal women
Post-menopausal women (without hormone replacement therapy)
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
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Dynamic lung volume: end-expiratory lung volume (EELV), end-inspiratory lung volume (EILV)
大体时间:At least 1 year post-menopause
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At least 1 year post-menopause
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次要结果测量
结果测量 |
大体时间 |
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Pulmonary function
大体时间:At least 1 year post-menopause
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At least 1 year post-menopause
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Breathing pattern
大体时间:At least 1 year post-menopause
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At least 1 year post-menopause
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Ventilatory response
大体时间:At least 1 year post-menopause
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At least 1 year post-menopause
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Visual analog scale (VAS) for dyspnea and leg fatigue
大体时间:At least 1 year post-menopause
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At least 1 year post-menopause
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合作者和调查者
调查人员
- 首席研究员:Li-Ying Wang, Ph.D.、School and Graduate Institute of Physical Therapy, National Taiwan University
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 9461701144
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