Effects of Treatment With High Flow Nasal Cannulas on Respiratory Pattern and Work of Breathing Among Healthy Subjects (HDWOBSS)
연구 개요
상세 설명
High flow oxygen therapy (HFOT) is a promising technique increasingly used in the management of acute respiratory failure. In hospitalised hypoxemic patients, recent clinical evidence showed that HFOT can reduce endotracheal intubation and reduce mortality. Physiologically, the HFOT causes a decrease in respiratory rate and minute-ventilation and may be associated with a decrease in carbone dioxyde arterial pressure. It is possible that these effects are associated with decreased work of breathing, which could explain some of the benefits in terms of comfort and efficiency.
The objective of this research is to evaluate the impact of a wash-out of anatomical dead space by high flow nasal cannulas on respiratory parameters and on the work of breathing among healthy subjects. The investigators will evaluate the baseline status in room air, and then compare it with four different levels of flow. The primary endpoint will be the work of breathing.
연구 유형
등록 (예상)
단계
- 해당 없음
연락처 및 위치
연구 장소
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Quebec
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Québec, Quebec, 캐나다, G1V4G5
- 모병
- Centre de recherche de l'IUCPQ
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연락하다:
- François Lellouche, MD, PhD
- 전화번호: 3298 418-656-8711
- 이메일: francois.lellouche@criucpq.ulaval.ca
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
- Healthy subjects
- Written and informed consent
Exclusion Criteria:
- Pregnant or breastfeeding women;
- Subject enrolled in another study excluding co-enrolment;
- Cardio-vascular or respiratory disease;
- History of ear nose and throat disease (i.e. surgery, epistaxis, trauma), eso-gastric disease (i.e. esophageal varices, digestive haemorrhage), rheumatologic or neurologic disease possibly interfering with the design of the study;
- Subject feeling nauseous or under recent fed condition (<1h).
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 크로스오버 할당
- 마스킹: 하나의
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
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간섭 없음: No flow
Subjects will be spontaneously breathing in room air with no flow.
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실험적: Conventional flow via nasal prongs
Subjects will be breathing with nasal prongs delivering 5 L/min of air (inspired fraction of oxygen: 0.21)
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Low flow of air delivered through conventional nasal prongs
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실험적: High flow nasal cannulas 20 L/min
Subjects will be breathing with high flow nasal cannulas delivering 20 L/min with an inspired fraction of oxygen of 0.21.
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Comparison of different flow levels
다른 이름들:
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실험적: High flow nasal cannulas 40 L/min
Subjects will be breathing with high flow nasal cannulas delivering 40 L/min with an inspired fraction of oxygen of 0.21.
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Comparison of different flow levels
다른 이름들:
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실험적: High flow nasal cannulas 60 L/min
Subjects will be breathing with high flow nasal cannulas delivering 60 L/min with an inspired fraction of oxygen of 0.21.
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Comparison of different flow levels
다른 이름들:
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Work of breathing
기간: 10 minutes
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Work of breathing at the end of each period is calculated from the measurement of esophageal pressure and tidal volume (composite outcome).
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10 minutes
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Esophageal pressure-time product
기간: 10 minutes
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Measured at the end of each period
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10 minutes
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Tidal Volume
기간: 10 minutes
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Measured at the end of each period
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10 minutes
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Comfort of breathing
기간: 10 minutes
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Subjective evaluation at the end of each period
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10 minutes
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Blood gases
기간: 10 minutes
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Arterial or capillary blood gases at the end of each period
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10 minutes
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Dyspnea
기간: 10 minutes
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Evaluation on a borg scale at the end of each period
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10 minutes
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Respiratory Rate
기간: 10 minutes
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Measured at the end of each period
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10 minutes
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End-tidal carbon dioxide
기간: 10 minutes
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Measured at the end of each period
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10 minutes
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Heart rate
기간: 10 minutes
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Measured at the end of each period
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10 minutes
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Oxygen saturation
기간: 10 minutes
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Measured at the end of each period
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10 minutes
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공동 작업자 및 조사자
스폰서
수사관
- 연구 책임자: François Lellouche, MD, PhD, Fondation IUCPQ
간행물 및 유용한 링크
연구 기록 날짜
연구 주요 날짜
연구 시작
기본 완료 (예상)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (추정)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
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