- ICH GCP
- 미국 임상 시험 레지스트리
- 임상시험 NCT03031977
Visceral Mobilization and Functional Constipation in Stroke Survivors
Visceral Mobilization and Functional Constipation in Stroke Survivors: a Randomized, Controlled, Double-blind, Clinical Trial
연구 개요
상세 설명
Procedures
All volunteers received clarifications with regard to the procedures and were informed that the procedures would not affect their health. The volunteers were assured that all information would be confidential and their privacy would remain protected. All volunteers who agreed to participate in the study signed a statement of informed consent in compliance with Resolution 196/96 of the Brazilian National Board of Health.
Sham intervention procedures were always performed in combination with active conventional therapy, which lessened the impact the sham procedure on the patient. Moreover, the patients were informed of the use of this procedure prior to the onset of the study.
Randomization, evaluation and intervention
Thirty individuals met the eligibility criteria and were randomly allocated to one of the two study groups using a block randomization method. Fifteen patients were allocated to each group: Experimental group - conventional physical therapy and visceral mobilization; control group: conventional physical therapy and sham mobilization. Block randomization involved the use of sealed opaque envelopes, each containing a card stipulating one of the two groups. After the pre-intervention evaluation, the participant was allocated to a group by opening an envelope. This process was performed by a member of the research team who was not involved in the recruitment process or development of the study.
Evaluations were performed on three occasions: 1) prior to the intervention; 2) immediately after the first session; and 3) one week after the last session. All specific evaluation procedures were performed during the pre-intervention and post-intervention (one week after the sessions) evaluations, whereas only the computerized plantar pressure evaluation was performed at the second evaluation (immediately after the first session). The researcher in charge of the evaluations was blinded to the objectives of the study and did not take part in the intervention protocols. Moreover, the order of the evaluations was randomized to avoid the effect of standardization.
First, an identification chart was filled out with information on age, sex, date of stroke episode and onset of constipation. Anthropometric data (body mass and height) were also measured and recorded. The specific evaluation procedures consisted of the use of an intestinal symptoms rating scale(16) (primary outcome) and plantar pressure evaluation (secondary outcome).
The ten-item intestinal symptoms rating scale was used to measure the intensity of intestinal symptoms. On this scale, each item is scored from 0 to 4 points. Item 1 regards the frequency of bowel movements and Items 2 to 10 address intestinal symptoms. The final scores is calculated by the mean of the item scores; 0 corresponds to a absence of symptoms and 4 corresponds to the highest intensity of symptoms.(16) The plantar pressure evaluation was performed using a force plate (Medicapteurs France S-Plate) with 1600 sensors and an acquisition frequency of 100 images per second. This force plate measures the distribution of plantar pressure during quiet standing, with quantitative data on anteroposterior and mediolateral sway (cm) as well as the mean sway velocity (cm/s) in these directions. The volunteer stood barefoot on the pressure plate in the standing position with arms alongside the body, gaze fixed on the horizon, lips closed, with the mandible and rest of the body relaxed. Readings were performed for 50 seconds, the 30 intermediate seconds of which were used for analysis. The values were recorded using the program provided by the manufacturer installed on a microcomputer.
Both groups were submitted to general kinesiotherapy with a focus on strengthening, stretching and proprioception during conventional physical therapy. The experimental group was also submitted to mobilization of the ascending colon, descending colon, sigmoid colon and sphincters (cardiac, pyloric, Oddi, duodenojejunal and ileocecal) with the patient in the supine position, knees flexed, feet supported and abdomen exposed. Contact was made with the region to be treated, leading it in the direction of immobility, with pressure maintained for one minute on each region with intensity based on the sensitivity to tension observed on the feedback of the individual. In the control group, sham mobilization was performed, which consisted of superficial contact with no pressure on the abdominal region corresponding to the loops of the large intestine. Five intervention sessions were held over a two-week period.
Statistical analysis
The data were first submitted to the Kolmogorov-Smirnov test to determine adherence to the Gaussian curve. The independent t-test was used for the inter-group analysis. Repeated-measures ANOVA was used for the intra-group analysis under each condition. The chi-square test was used to evaluate the dispersion of the qualitative variables in the intra-group and inter-group analyses. A p-value ≤ 0.05 was considered indicative of statistical significance. The data were organized and tabulated using the Statistical Package for the Social Sciences (SPSS v.19.0).
연구 유형
등록 (실제)
단계
- 해당 없음
참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
- Male and female patients aged 40 to 70 years having suffered a stroke more than one year earlier with hemiparesis secondary to a single unilateral event
- The capacity for independent gait and a complaint of chronic constipation for more than six months in accordance with the definition of functional constipation described by the Rome III Consensus
Exclusion Criteria:
- Incision or tumor in the abdominal region
- fractures
- rheumatic disease
- infectious process in the acute phase
- inability to understand the proposed evaluations
- inability to walk or maintain balance in an independent manner
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 더블
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
---|---|
실험적: visceral mobilization
Conventional physical therapy and visceral mobilization.
The experimental group was also submitted to mobilization of the ascending colon, descending colon, sigmoid colon and sphincters (cardiac, pyloric, Oddi, duodenojejunal and ileocecal) with the patient in the supine position, knees flexed, feet supported and abdomen exposed.
Contact was made with the region to be treated, leading it in the direction of immobility, with pressure maintained for one minute on each region with intensity based on the sensitivity to tension observed on the feedback of the individual.
|
|
가짜 비교기: sham mobilization
Conventional physical therapy and sham mobilization.
In the control group, sham mobilization was performed, which consisted of superficial contact with no pressure on the abdominal region corresponding to the loops of the large intestine.
|
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
---|---|---|
intestinal symptoms rating scale
기간: 1 month
|
The ten-item intestinal symptoms rating scale was used to measure the intensity of intestinal symptoms.
On this scale, each item is scored from 0 to 4 points.
Item 1 regards the frequency of bowel movements and Items 2 to 10 address intestinal symptoms.
The final scores is calculated by the mean of the item scores; 0 corresponds to a absence of symptoms and 4 corresponds to the highest intensity of symptoms.
|
1 month
|
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
---|---|---|
plantar pressure evaluation
기간: 1 month
|
The plantar pressure evaluation was performed using a force plate (Medicapteurs France S-Plate) with 1600 sensors and an acquisition frequency of 100 images per second.
This force plate measures the distribution of plantar pressure during quiet standing, with quantitative data on anteroposterior and mediolateral sway (cm) as well as the mean sway velocity (cm/s) in these directions.
|
1 month
|
공동 작업자 및 조사자
연구 기록 날짜
연구 주요 날짜
연구 시작
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (추정)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
visceral mobilization에 대한 임상 시험
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Alabama Physical Therapy & AcupunctureUniversidad Rey Juan Carlos모병
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Universidade Federal de Sao CarlosCoordenação de Aperfeiçoamento de Pessoal de Nível Superior.완전한
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Riphah International University완전한