The Effects of an L-histidine-Based Supplement, Eczema Topical, and Unscented Soap on Children With Eczema

Experimenteel: Group 1 (ages 1-3 years)

The participant is provided with a daily powder supplement containing 0.8g of L-histidine, a topical oil to be used at least twice daily, and an unscented soap to be used twice daily.

Ander: Powder Supplement + Topical Oil + Unscented Soap

The intervention includes 3 products:

1. A powder dietary supplement containing 0.8g of L-histidine to be mixed with food or liquid of choice.
2. A topical oil to be used at least twice daily and as often as needed on the face and body.
3. An unscented soap to be used twice daily (in the morning and evening) on the face and body, in replacement of the usual cleansing product.

Experimenteel: Group 2 (ages 4-12 years)

The participant is provided with daily gummy supplements containing 0.8g of L-histidine, a topical lotion to be used at least twice daily, and an unscented soap to be used twice daily.

Ander: Gummy Supplement + Topical Lotion + Unscented Soap

The intervention includes 3 products: 1. Gummy supplements containing 0.8g of L-histidine. 2. A topical lotion to be used at least twice daily and as often as needed on the face and body. 3. An unscented soap to be used twice daily (in the morning and evening) on the face and body, in replacement of the usual cleansing product.

Objectieve en subjectieve score van de ernst van eczeem

Verandering in de ernst van eczeem werd beoordeeld met behulp van Scorad (scoren van atopische dermatitis). A. Ten eerste wordt de verspreiding van eczeem op verschillende lichaamsgebieden beoordeeld door de onderzoeker en berekend als een percentage, waarbij het maximum 100%is. B. Ten tweede, de intensiteit van huid roodheid, zwelling, sijpelen, krassporen, huidverdikking en droogheid wordt gescoord door de onderzoeker van 0 tot 3, waar 0 is, geen, 1 is mild, 2 is matig en 3 is ernstig. C. Ten slotte wordt voor de subjectieve score gevraagd om de intensiteit van symptomen (jeuk en slapeloosheid) te melden van 0 tot 10, waar 0 geen jeuk is of geen slapeloosheid, en 10 is de slechtst denkbare jeuk of slapeloosheid. De totale score van de objectieve scorad wordt verkregen met de volgende formule: scorad = a/5 + 7 b/2 + c

Objectieve en subjectieve score van de ernst van eczeem

Verandering in de ernst van eczeem werd beoordeeld met behulp van Scorad (scoren van atopische dermatitis). A. Ten eerste wordt de verspreiding van eczeem op verschillende lichaamsgebieden beoordeeld door de onderzoeker en berekend als een percentage, waarbij het maximum 100%is. B. Ten tweede, de intensiteit van huid roodheid, zwelling, sijpelen, krassporen, huidverdikking en droogheid wordt gescoord door de onderzoeker van 0 tot 3, waar 0 is, geen, 1 is mild, 2 is matig en 3 is ernstig. C. Ten slotte wordt voor de subjectieve score gevraagd om de intensiteit van symptomen (jeuk en slapeloosheid) te melden van 0 tot 10, waar 0 geen jeuk is of geen slapeloosheid, en 10 is de slechtst denkbare jeuk of slapeloosheid. De totale score van de objectieve scorad wordt verkregen met de volgende formule: scorad = a/5 + 7 b/2 + c

Eczema Area Severity Index (EASI) score

Change in eczema severity is assessed with the Eczema Area and Severity Index (EASI). Skin redness, elevation, scratching, and thickening are assessed by the investigator at 4 body regions on a scale of 0 to 3, where 0 is none, 1 is mild, 2 is moderate, 3 is severe. The EASI is the sum of these scores.

Eczema Area Severity Index (EASI) score

Change in eczema severity is assessed with the Eczema Area and Severity Index (EASI). Skin redness, elevation, scratching, and thickening are assessed by the investigator at 4 body regions on a scale of 0 to 3, where 0 is none, 1 is mild, 2 is moderate, 3 is severe. The EASI is the sum of these scores.

Quality of Sleep

Parent/guardian will fill out the Children Sleep Habit's questionnaire for their child. This questionnaire inquires about bedtime, sleep behavior, waking during the night, and morning wake-up. Possible answers include: "Always", "Usually", "Sometimes", "Rarely", and "Never".

"Always" is selected if a certain behavior occurs every night, "Usually" is selected if it occurs 5 or 6 times a week, "Sometimes" if it occurs 2 to 4 times a week, "Rarely" if it occurs once a week, and "Never" if it occurs less than once a week.

Quality of Sleep

Parent/guardian will fill out the Children Sleep Habit's questionnaire for their child. This questionnaire inquires about bedtime, sleep behavior, waking during the night, and morning wake-up. Possible answers include: "Always", "Usually", "Sometimes", "Rarely", and "Never".

"Always" is selected if a certain behavior occurs every night, "Usually" is selected if it occurs 5 or 6 times a week, "Sometimes" if it occurs 2 to 4 times a week, "Rarely" if it occurs once a week, and "Never" if it occurs less than once a week.

Subjective Eczema Severity

Parent/guardian will fill out the Patient-Oriented Eczema Measure (POEM). This includes 7 questions about the number of days over the last week that their child experienced certain symptoms of eczema. Possible answers include: "No Days", "1-2 Days", "3-4 Days", "5-6 Days", or "Everyday".

Subjective Eczema Severity

Parent/guardian will fill out the Patient-Oriented Eczema Measure (POEM). This includes 7 questions about the number of days over the last week that their child experienced certain symptoms of eczema. Possible answers include: "No Days", "1-2 Days", "3-4 Days", "5-6 Days", or "Everyday".

Emotional and Behavioral Questionnaire

Parent/guardian will fill out the Pediatric Symptom Checklist-17 (PSC-17) for their child. It includes 17 questions that relate to how often a certain behaviors or mood occurs. Answers include "Never", "Sometimes", "Often".

Emotional and Behavioral Questionnaire

Parent/guardian will fill out the Pediatric Symptom Checklist-17 (PSC-17) for their child. It includes 17 questions that relate to how often a certain behaviors or mood occurs. Answers include "Never", "Sometimes", "Often".