Striatal circuits, habits, and implications for obsessive-compulsive disorder
Eric Burguière, Patricia Monteiro, Luc Mallet, Guoping Feng, Ann M Graybiel, Eric Burguière, Patricia Monteiro, Luc Mallet, Guoping Feng, Ann M Graybiel
Abstract
Increasing evidence implicates abnormalities in corticostriatal circuits in the pathophysiology of obsessive-compulsive disorder (OCD) and OC-spectrum disorders. Parallels between the emergence of repetitive, compulsive behaviors and the acquisition of automated behaviors suggest that the expression of compulsions could in part involve loss of control of such habitual behaviors. The view that striatal circuit dysfunction is involved in OC-spectrum disorders is strengthened by imaging and other evidence in humans, by discovery of genes related to OCD syndromes, and by functional studies in animal models of these disorders. We highlight this growing concordance of work in genetics and neurobiology suggesting that frontostriatal circuits, and their links with basal ganglia, thalamus and brainstem, are promising candidates for therapeutic intervention in OCD.
Conflict of interest statement
Conflict of interest statement
We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.
Copyright © 2014 Elsevier Ltd. All rights reserved.
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Source: PubMed