High dosage metolazone in chronic renal failure
H J Dargie, M E Allison, A C Kennedy, M J Gray, H J Dargie, M E Allison, A C Kennedy, M J Gray
Abstract
Metolazone is a modified quinazolinesulphonamide and in a dose of between 4 and 7.5 mg is an effective diuretic in man with normal renal function. Fourteen patients with non-oedematous stable chronic renal failure (creatinine clearance ranging from 1.2 to 12 ml/min) were given metolazone in doses ranging from 20-150 mg. A noticeable increase in urine flow and sodium excretion occurred, free water clearance increased, and there was a small but significant increase in potassium excretion. No side effects were noted.
References
- JAMA. 1966 Mar 21;195(12):1066-9
- Ann N Y Acad Sci. 1966 Nov 22;139(2):453-65
- Ann N Y Acad Sci. 1966 Nov 22;139(2):471-80
- Ann Intern Med. 1968 Aug;69(2):249-61
- Acta Med Scand. 1968 Dec;184(6):473-9
- Arch Int Pharmacodyn Ther. 1969 Jan;177(1):71-87
- N Y State J Med. 1971 Mar 1;71(5):566-9
- Clin Sci. 1971 Sep;41(3):171-87
- Kidney Int. 1972 Mar;1(3):169-81
- Circulation. 1961 Feb;23:200-10
- Ann Intern Med. 1965 Jan;62:15-29
- Proc Soc Exp Biol Med. 1950 May;74(1):148-51
Source: PubMed