Maternal and neonatal response to COVID-19

Thea N Golden, Rebecca A Simmons, Thea N Golden, Rebecca A Simmons

Abstract

The risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to maternal and newborn health has yet to be determined. Several reports suggest pregnancy does not typically increase the severity of maternal disease; however, cases of preeclampsia and preterm birth have been infrequently reported. Reports of placental infection and vertical transmission are rare. Interestingly, despite lack of SARS-CoV-2 placenta infection, there are several reports of significant abnormalities in placenta morphology. Continued research on pregnant women infected with SARS-CoV-2 and their offspring is vitally important.

Keywords: COVID-19; placenta; pregnancy.

Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the authors.

Figures

Fig. 1.
Fig. 1.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pregnancy and the newborn. A: graphical representation of the maternal fetal interface. B: placenta villus and maternal capillary showing localization of the receptor [angiotensin-converting enzyme 2 (ACE2)] for SARS-CoV-2. C: SARS-CoV-2 infectivity.

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